Articles tagged "Antibodies"

2016 American Transplant Congress
BK Nephropathy, but Not Isolated BK Viremia Associated with De Novo DSA Despite Similar Immunosuppression Reduction.
W. Cheungpasitporn,¹ D. Mitema,¹ H. Amer,¹ F. Cosio,¹ M. Stegall,² C. Schinstock.¹
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Rochester, MN.
Introduction: Reduced immunosuppression is associated with de novo DSA (dn DSA). Although immunosuppression is often reduced in patients with polyomavirus (BK), the incidence of dn…
2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Everolimus and Low Dose Cyclosporine Immunosuppressive Regimen and Development of Anti HLA Donor Specific Antibodies.
E. Minetti,¹ L. Di Maria,¹ L. Caroti,¹ E. Buti,² P. Carta.¹
¹Nephrology unit, Careggi University Hospital, Florence, Italy; ²Nephrology Unit, Mayer Univerity Hospital, Florence, Italy.
Few data are available on the rate of de novo anti-HLA donor specific antibodies (DSA) with the use of everolimus in kidney transplant recipients.MaterialsWe selected…
2016 American Transplant Congress
Focal C4d Staining in Biopsies of Kidney Transplant Recipients Is Not Associated with Antibody Mediated Rejection and Does Not Correlate with Graft Survival.
R. Prashar, M. Goggins, L. Yessayan, A. Patel, M. Goggins.
Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While diffuse C4d positivity in kidney transplant peritubular capillaries(PTC) strongly co-relates with the presence of antibody mediated rejection(AMR),data on the significance of focal C4d…
2016 American Transplant Congress
Antibody-Mediated Rejection in Pancreas Transplantation.
O. Serrano,¹ D. Vock,² E. Finger,¹ R. Kandaswamy,¹ D. Sutherland,¹ T. Dunn.¹
¹Surgery, Univ. of Minnesota, Minneapolis, MN; ²Biostatistics, University of Minnesota, Minneapolis, MN.
PURPOSE: The diagnostic criteria for antibody-mediated rejection (AMR) in pancreas transplantation (PTx) is evolving. The incidence and long-term effect of AMR have not been well-described.…
2016 American Transplant Congress
Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.
H. Sakai, Y. Tanaka, H. Ohdan.
Hiroshima University, Hiroshima, Japan.
[Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…
2016 American Transplant Congress
Treatment for AMR and DSA: A Center Based Review of Pediatric Orthotopic Heart Transplant Recipients.
D. Drogalis-Kim,¹ M. Hickey,² J. Alejos,¹ E. Reed,² N. Halnon.¹
¹Department of Pediatric Cardiology, UCLA, Los Angeles, CA; ²Department of Immunogenetics, UCLA, Los Angeles, CA.
PURPOSE: The aim of this study was to retrospectively analyze the clinical course of pediatric orthotopic heart transplant patients diagnosed with antibody mediated rejection (AMR+)…
2016 American Transplant Congress
Impact of Angiotensin II Type I Receptor Antibody Positivity in Highly-HLA Sensitized (HS) Patients Transplanted After Desensitization (DES).
A. Vo,¹ C. Boutsicaris,¹ X. Zhang,² N. Reinsmoen,² J. Choi,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²HLA Laboratory, Cedars-Sinai Medical Center, LA, CA.
Introduction: Angiotensin II type I receptor antibody (AT1R Ab) is a target for non-HLA antibodies. AT1R ab exert direct effects on endothelial and vascular smooth…
2016 American Transplant Congress
Anti-Angiotensin II Type 1 Receptor Antibody Reduction with Proteasome Inhibitor-Based Desensitization.
A. Girnita, E. Portwood, P. Brailey, S. Tremblay, R. Alloway, E. Woodle.
University of Cincinnati, Cincinnati.
Background. Desensitization results have largely focused on effects on anti-HLA antibody (HLA-Ab) and anti-ABO antibody levels. Anti-angiotensin II type 1 receptor antibody (AT1R-Ab) has recently…
2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…