2016 American Transplant Congress
Real Time Assessment of Kidney Transplant Indication Biopsies by Microarrays: First Results of the INTERCOMEX Study.
1University of Alberta, Edmonton, Canada; 2ATAGC, Edmonton, Canada.
Oncology uses central molecular tissue assessment (MTA) to guide management but the potential of this approach in transplantation is not known. We undertook a prospective…2016 American Transplant Congress
Blocking Fc Receptor in Flow Cytometric Crossmatch: Refining an Old Assay to Improve Patient Management.
Pathology, University of Chicago, Chicago, IL.
Introduction: The crossmatch assay is used to determine sensitization of solid organ transplant recipients to donor-expressed HLA molecules, a potential contraindication to transplant. Multicolor flow…2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…2016 American Transplant Congress
The Coefficient of Variability of Tacrolimus Levels Can Predict Antibody-Mediated Rejection After Renal Transplantation.
Introduction. Antibody-mediated rejection (ABMR) is the major cause of allograft failure. We studied whether the coefficient of variability (CV) of blood levels of tacrolimus can…2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…2016 American Transplant Congress
IgM Donor Specific Antibodies Are Frequently Associated with C1q-binding DnDSA in Renal Transplant Recipients.
Background: Recently, the importance of complement-binding de novo DSA (dnDSA) was documented. We aimed to explore the presence of IgM dnDSA according to C1q dnDSA-binding…2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…2016 American Transplant Congress
IVIG and High Dose Steroid Treatment of Transplant Glomerulopathy Effectively Slows Progression of Loss of Renal Allograft Function.
Introduction Transplant glomerulopathy (TG) is commonly associated with chronic antibody mediated rejection and is a major cause of late kidney allograft loss with no established…2016 American Transplant Congress
First Clinical Experience with Belatacept in 3 Hand Transplanted Patients.
Study purposeBelatacept (CTLA4Ig) is an emerging treatment in solid organ transplantation. Effects on the development of donor specific antibodies (DSA) as well as its clinical…2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
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