Articles tagged "Antibodies"

2016 American Transplant Congress
Poor HLA Matching May Reduce the Beneficial Effect of ABOi Pairs Entering the Paired and Pooled Scheme.
M. Willicombe, C. Lawrence, R. Charif, A. McLean, J. Galliford, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Introduction: Paired/pooled donation (PPD) facilitates transplantation between UK donor-recipient pairs who are either HLA or blood group incompatible, in whom transplantation is either contraindicated or…
2016 American Transplant Congress
Preformed Antibodies Against AT₁R and EDNRA Correlate with Rejection Post-Transplant.
A. Gareau,¹ C. Wiebe,^1,2 D. Pochinco,² I. Gibson,³ D. Rush,¹ P. Nickerson.^1,2,4
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Immunology, University of Manitoba, Winnipeg, MB, Canada.
Studies have investigated the potential pathogenic effects of non-HLA antibodies (Ab), with a few reporting that Ab against the angiotensin II type 1 receptor (AT1R)…
2016 American Transplant Congress
Reduced Incidence and Level of De Novo Donor-Specific Antibodies in Belatacept-Treated vs. Cyclosporine-Treated Patients: Final Results from BENEFIT.
R. Bray,¹ H. Gebel,¹ R. Townsend,² M. Polinsky,² L. Yang,² U. Meier-Kriesche,² C. Larsen.¹
¹Emory University, Atlanta, GA; ²Bristol-Myers Squibb, Lawrenceville, NJ.
Background: The presence of donor-specific antibodies (DSA) has been associated with an increased risk of antibody-mediated rejection and graft failure. Mean fluorescence intensity (MFI) is…
2016 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Are Associated with Allograft Loss in Pediatric Renal Transplantation.
M. Pearl,¹ Q. Zhang,² M. Palma Diaz,³ J. Grotts,⁴ J. Brook,⁴ D. Gjertson,² P. Weng,¹ E. Reed,² E. Tsai.¹
¹Pediatrics, University of California-Los Angeles, Los Angeles, CA; ²Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, CA; ³Anatomic & Clinical Pathology, University of California-Los Angeles, Los Angeles, CA; ⁴Biostatistics, University of California-Los Angeles, Los Angeles, CA.
Background: Angiotensin II type 1 receptor antibody (AT1R-Ab) is associated with vascular injury and allograft failure in adult kidney transplantation. Its role in pediatric transplantation…
2016 American Transplant Congress
Urine Cell-Free Supernatant Metabolites Diagnostic of Antibody Mediated Rejection in Kidney Allografts.
M. Alkadi,¹ J. Lee,¹ D. Dadhania,¹ T. Muthukumar,¹ C. Snopkowski,¹ C. Li,¹ S. Salvatore,¹ S. Seshan,¹ K. Suhre,² M. Suthanthiran.¹
¹Weill Cornell Medicine, NY; ²Weill Cornell Medical College-Qatar, Doha, Qatar.
Introduction:Urine cell-free supernatant metabolite profiles provide a unique opportunity to interrogate intra-graft processes and have distinguished acute cellular rejection from no rejection in the Clinical…
2016 American Transplant Congress
Bone Allograft: An Unusual Cause of Sensitization.
J. Bloch,¹ V. Elsermans,² F. Provôt,¹ A. Lionet,¹ L. Wajbrot-Houzé,³ C. Noel,¹ M. Hazzan.¹
¹Service de Néphologie et Transplantation, CHRU, Hopital Claude Huriez, Lille, France; ²Institut d'Immunologie, CHRU, Centre de Biologie et Pathologie, Lille, France; ³Service de Néphrologie, Centre Hospitalier de Béthune, Béthune, France.
We report the case of a 33 year-old female patient who started hemodialysis in 2009 because of end stage renal disease of unknown etiology. When…
2016 American Transplant Congress
Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).
D. Soonawala,¹ K. Groeneweg,¹ F. van der Toorn,¹ S. Heidt,² D. Roelen,² F. Claas,² J. de Fijter.¹
¹Nephrology, LUMC, Leiden, Netherlands; ²IHB, LUMC, Leiden, Netherlands.
Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…
2016 American Transplant Congress
Optimal Integration of Kidney Exchange Programs with Antibody Reduction Therapy to Increase Successful Transplant in Difficult to Match Recipients.
K. Melancon,¹ N. Koizumi,² M. Gentili,³ C. Callender.⁴
¹Surgery, George Washington University Hospital, Washington, DC; ²Public Policy, George Mason Univ, Arlington, VA; ³Operations Research, University of Louisville, Louisville, KY; ⁴Surgery, Howard University Hospital, Washington, DC.
Kidney paired donation (KPD) allows incompatible pairs to exchange kidneys with other incompatible pairs. However, evidence suggests there stills exist barriers to KPD utilization, especially…
2016 American Transplant Congress
Monitoring of De Novo DSA Post Alemtuzumab Induction in Renal Transplant Recipients: One Year Follow Up.
Y. Nigatu, C. Estrada, F. Darras, H. Suh, M. Abate, E. Nord.
Nephrology & Hypertension, Stony Brook Medicine, Stony Brook, NY.
IntroductionThe presence of de novo DSA (dnDSA) is associated with antibody mediated rejection and less optimal graft outcomes. The overall incidence of dnDSA post renal…
2016 American Transplant Congress
Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.
M. Lubetzky,¹ P. O Broin,² Y. Bao,¹ E. Akalin.¹
¹Transplantation, Albert Einstein College of Medicine, Bronx; ²School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.
Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…