Articles tagged "Antibodies"

2016 American Transplant Congress
Factors Mediating Kidney Rejection in Patients of Simultaneous Liver-Kidney Transplants.
R. Dong, A. Tambur, L. Gallon, J. Levitsky.
Northwestern, Chicago, IL.
BACKGROUND & AIM: Kidney grafts in simultaneous liver-kidney (SLK) recipients are considered to be immunologically protected due to hepatic tolerance, although recent studies have alternatively…
2016 American Transplant Congress
Assessment of Chikungunya IgM Prevalence Among Deceased Organ and Tissue Donors Using Two Enzyme Immunoassay (EIA) Kits.
H. Prince, M. Altrich, M. Nowicki.
Viracor-IBT Laboratories, Los Angeles, CA.
Study Purpose: The emergence of Chikunungya virus (ChikV) infection in the western hemisphere has raised concerns of donor-derived transmission. We assessed the prevalence of recent…
2016 American Transplant Congress
Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.
V. Cantaluppi,¹ S. Dellepiane,² D. Medica,² G. Tognarelli,² M. Quaglia,¹ C. Musetti,¹ A. Airoldi,¹ L. Biancone.²
¹Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.
Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
2016 American Transplant Congress
Membranoproliferative Glomerulonephritis Pattern without Immunoglobulin and Complement Deposition in Renal Allograft Was Related to the Injury of Antibody-Mediated Rejection.
J. Wen, F. Xu, J. Chen, X. Li, M. Zhang, Z. Zhang, Z. Liu.
National Clinical Research Center of Kidney Diseases, Nanjing, China.
Background: Differential diagnosis of Membranoproliferative Glomerulonephritis (MPGN) in renal allograft was difficult because of the confused etiology. Recurrent or de novo MPGN were related to…
2016 American Transplant Congress
The Effect of Tocilizmab Treatment (TCZ-Rx) on Total IgG and Anti-CMV-IgG Levels in HLA-Sensitized (HS) Kidney Transplant Patients.
B.-H. Shin, S. Ge, J. Choi, J. Kahwaji, A. Vo, A. Petrosyan, S. Jordan, M. Toyoda.
Transplant Immunology Lab, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: TCZ has anti-B cell and anti-inflammatory properties. We have reported its successful use for pre-transplant (Tx) desensitization (DES) and treatment of ABMR. We also…
2016 American Transplant Congress
The Impact of Complement Binding Donor Specific Antibodies in the First Year After Heart Transplantation.
J. Patel, M. Kittleson, D. Chang, T. Aintablian, A. Velleca, D. Ramzy, L. Czer, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: The development of donor specific antibodies (DSA) after heart transplant has been associated with poor outcome. We now have the ability to assess the…
2016 American Transplant Congress
Bortezomib Impacts Tenascin mRNA in PBMNCs.
E. Bradley, O. Moussa, K. Twombley.
Medical University of South Carolina, Charleston.
Tenascin (TNC) is a gene thought to play a role in the binding of receptors and syndecan binding. Syndecans are signal transmembrane proteins that act…
2016 American Transplant Congress
The Effect of Tocilizmab Treatment (TCZ-Rx) on IgG Subclasses in HLA-sensitized (HS) Kidney Transplant Patients Treated with TCZ.
B.-H. Shin, S. Ge, J. Choi, J. Kahwaji, A. Vo, A. Petrosyan, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Antibody-mediated rejection (ABMR) is a major obstacle for successful transplant in HS patients. TCZ has anti-B cell and anti-inflammatory properties. We have reported its…
2016 American Transplant Congress
The Early Outcomes of Bortezomib Therapy in Patients with Late Antibody Mediated Rejection in Renal Transplantation.
J. Choi, J. Jung, S. Shin, Y. Kim, D. Han.
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Although several strategies for treating antibody mediated rejection (AMR) in renal transplants have been investigated, the formation of donor-specific antibodies (DSA) and ongoing AMR contribute…
2016 American Transplant Congress
Ameliorating Progression of Allograft Vasculopathy by Targeting the T Follicular Helper Cell Subset.
M. Chhabra, J. Ali, J. Alsughayyir, S. Qureshi, J. Bradley, E. Bolton, R. Motallebzadeh, G. Pettigrew.
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
BACKGROUNDDevelopment of long-lived alloantibody is closely linked with chronic rejection and graft failure. We examined in a murine model of antibody-mediated rejection (AMR) if targeting…