Articles tagged "Antibodies"

2016 American Transplant Congress
Cross-Talk Between TLR and BCR Pathways Induces CNI-Resistance in B-Cells Responding to Blood Group A-Antigens: A Novel Paradigm for Treatment with TLR-Inhibitor for CNI-Resistant AMR.
H. Sakai, Y. Tanaka, H. Ohdan.
Hiroshima University, Hiroshima, Japan.
[Aim] Bacterial infections after ABO-incompatible transplantation are associated with refractory antibody (Ab)-mediated rejection (AMR). We demonstrated that bacterial pathogens provoke B cells, responding to human…
2016 American Transplant Congress
Treatment for AMR and DSA: A Center Based Review of Pediatric Orthotopic Heart Transplant Recipients.
D. Drogalis-Kim,¹ M. Hickey,² J. Alejos,¹ E. Reed,² N. Halnon.¹
¹Department of Pediatric Cardiology, UCLA, Los Angeles, CA; ²Department of Immunogenetics, UCLA, Los Angeles, CA.
PURPOSE: The aim of this study was to retrospectively analyze the clinical course of pediatric orthotopic heart transplant patients diagnosed with antibody mediated rejection (AMR+)…
2016 American Transplant Congress
Impact of Angiotensin II Type I Receptor Antibody Positivity in Highly-HLA Sensitized (HS) Patients Transplanted After Desensitization (DES).
A. Vo,¹ C. Boutsicaris,¹ X. Zhang,² N. Reinsmoen,² J. Choi,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²HLA Laboratory, Cedars-Sinai Medical Center, LA, CA.
Introduction: Angiotensin II type I receptor antibody (AT1R Ab) is a target for non-HLA antibodies. AT1R ab exert direct effects on endothelial and vascular smooth…
2016 American Transplant Congress
Anti-Angiotensin II Type 1 Receptor Antibody Reduction with Proteasome Inhibitor-Based Desensitization.
A. Girnita, E. Portwood, P. Brailey, S. Tremblay, R. Alloway, E. Woodle.
University of Cincinnati, Cincinnati.
Background. Desensitization results have largely focused on effects on anti-HLA antibody (HLA-Ab) and anti-ABO antibody levels. Anti-angiotensin II type 1 receptor antibody (AT1R-Ab) has recently…
2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…
2016 American Transplant Congress
Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.
J. Morales, M. Serrano, J. Martínez-Flores, D. Perez, M. Sevilla, O. Cabrera, A. Serrano.
Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are…
2016 American Transplant Congress
Outcomes of Second Kidney Transplantation Compared Primary Transplantation According to Donor Specific Antibody.
J. Lee,^1,2 K. Lee,¹ J. Lee,¹ S. Song,¹ J. Lee,¹ S.-K. Kwon,¹ D. Joo,^1,2 K. Huh,^1,2 M. Kim,^1,2 S. Kim,^1,2 Y. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Background:Re-transplantation is associated with an improved overall survival of patients with a failed renal allograft. Some studies showed the outcomes of retransplantation are than those…
2016 American Transplant Congress
Diversity of Influenza Antibody Repertoire in Transplant Recipients with Natural Influenza Infection.
V. Ferreira, A. Chruscinski, S. Han, A. Humar, D. Kumar.
Multi-Organ Transplant, UHN, Toronto, Canada.
Background: The nature of the immune response to seasonal Influenza A Virus infection has not been well characterized in transplant patients. Antibodies may be directed…
2016 American Transplant Congress
Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.
B. Adam,¹ I. Rosales,² T. Oura,² R. Smith,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Harvard Medical School and Massachusetts General Hospital, Boston.
Background: In 2013, the Banff classification proposed molecular testing as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. We analyzed whether…
2016 American Transplant Congress
Prospective Single Antigen Bead Epitope-Based Clustering for Early Detection of Antibody Mediated Rejection.
A. Lichvar, S. Tremblay, P. Brailey, A. Girnita, R. Alloway, E. Woodle.
U of Cincinnati, Cincinnati.
Purpose:Epitope-based groups of HLA single antigen beads (SAB) often demonstrate clustering in patients with donor specific antibodies (DSA). Coordinated Mean Florescent Intensity (MFI) increases of…