Articles tagged "Antibodies"

2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
P. Paul,^1,2 C. Picard,^3,4 E. Sampol,⁵ L. Lyonnet,¹ J. Di Cristofaro,^3,4 G. Lano,^6, B. Dussol,^6, F. Collart,⁷ F. Sabatier,^1,2 F. Dignat George,^1,2 A. Mouly Bandini.⁷
¹Hematology, Assistance Publique-Hopitaux Marseille (AP-HM), Marseille, France; ²UMR-1076, Aix Marseille Université (AMU), INSERM, Marseille, France; ³Établissement Français du Sang, Marseille, France; ⁴UMR7268, AMU, CNRS, Marseille, France; ⁵Pharmacokinetics, AP-HM, Marseille, France; ⁶Center for Clinical Investigation, AP-HM, Marseille, France; ⁷Cardiac Surgery, AP-HM, Marseille, France.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…
2016 American Transplant Congress
IgM Donor Specific Antibodies Are Frequently Associated with C1q-binding DnDSA in Renal Transplant Recipients.
J. Bamoulid,³ A. Roodenburg,⁴ O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹
¹Nephrologie, Charite Universität Medizin, Berlin, Germany; ²HLA Labor, Charite Universität Medizin, Berlin, Germany; ³Nephrologie, CHU Jean Minjoz, Besançon, France; ⁴Erasmus Medical Centre, Rotterdam, Netherlands.
Background: Recently, the importance of complement-binding de novo DSA (dnDSA) was documented. We aimed to explore the presence of IgM dnDSA according to C1q dnDSA-binding…
2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
B. Motyka,¹ B. Lamarche,¹ K. Labonte,¹ S. Wang,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹
¹Alberta Transplant Institute/CNTRP, University of Alberta, Edmonton, Canada; ²Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
2016 American Transplant Congress
IVIG and High Dose Steroid Treatment of Transplant Glomerulopathy Effectively Slows Progression of Loss of Renal Allograft Function.
K. Sablik,¹ C. Looman,² M. Clahsen-van Groningen,³ J. Damman,³ D. Roelen,⁴ M. van Agteren,¹ M. Betjes.¹
¹Nephrology and Transplantation, Erasmus MC University Center, Rotterdam, Netherlands; ²Biostatistics, Erasmus MC University Center, Rotterdam, Netherlands; ³Pathology, Erasmus MC University Center, Rotterdam, Netherlands; ⁴Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Introduction Transplant glomerulopathy (TG) is commonly associated with chronic antibody mediated rejection and is a major cause of late kidney allograft loss with no established…
2016 American Transplant Congress
First Clinical Experience with Belatacept in 3 Hand Transplanted Patients.
J. Grahammer,¹ B. Zelger,² B. Zelger,³ M. Ninkovic,¹ A. Muehlbacher,⁴ D. Oefner-Velano,¹ S. Schneeberger,¹ A. Weissenbacher.⁵
¹Viceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; ³Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁴Department of Blood Group Serology and Transfusion Medicine, Innsbruck Medical University, Innsbruck, Austria; ⁵Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.
Study purposeBelatacept (CTLA4Ig) is an emerging treatment in solid organ transplantation. Effects on the development of donor specific antibodies (DSA) as well as its clinical…
2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
A. Haririan,¹ M. Chaudhry,² J. Papadimitriou,² N. Costa,¹ B. Thomas,¹ M. Mavanur,¹ R. Ugarte,¹ C. Cangro,¹ C. Drachenberg.²
¹Dept of Medicine, Unniversity of Maryland, Baltimore, MD; ²Dept of Pathology, University of Maryland, Baltimore, MD.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
2016 American Transplant Congress
Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies.
J. He,¹ Z. Pan,¹ X. Yuan,¹ Y. Li,¹ X. Wu,² W. Zhu,² X. Bao,¹ Q. Zhao.²
¹Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; ²Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
The NMDP and CIBMTR provided guidelines for the use of anti-HLA antibodies in unrelated-donors hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other…
2016 American Transplant Congress
Elevated De Novo Donor Specific Antibody After Alemtuzumab Induction in Renal Transplant Recipients.
K. Fabbri, J. Descourouez, M. Jorgenson, R. Redfield.
University of Wisconsin, Madison.
Background: The average annual incidence of de novo donor specific antibody (DSA) has been reported as 3-4% after the first year post-transplant. Recent data suggests…
2016 American Transplant Congress
Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.
P. Halloran,¹ D. Kim,¹ A. Loupy,² J.-P. Duong Van-Huyen,² P. Bruneval,³ L. Potena,⁴ O. Leone,⁴ J. Reeve.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³Hopitaux de Paris, Paris, France; ⁴Bologna University, Bologna, Italy.
The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…
2016 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies in Renal Transplant Recipients Associated with Ventricular and Endothelial Dysfunction: Preliminary Results.
L. Figuerola-Chaparro,¹ F. Davila-Radilla,¹ E. Cuevas,² L. Castillo-Martínez,¹ A. Orea-Tejeda,¹ J. Arreola-Guerra,² J. Alberu.²
¹Cardiology, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico; ²Transplantation, Inst Nal Ciencias Medicas y Nutricion SZ, Mexico City, Mexico.
Previous studies demonstrated the significance of angiotensin II type-1 receptor antibodies (AT1Rabs) in processes including hypertension, cardiac hypertrophy and renal fibrosis; information regarding ventricular and…