Articles tagged "Antibodies"

2017 American Transplant Congress
Saftey & Long Term Outcomes of Tocilizumab (Anti-IL6R, TCZ) Therapy in Treatment of Chronic Antibody Mediated Rejection (CABMR) & Transplant Glomerulopathy (TG) in Highly-HLA Sensitized (HS) Patients (PTs).
J. Choi,¹ O. Aubert,² A. Vo,¹ A. Loupy,² M. Haas,³ S. Louie,¹ A. Kang,¹ A. Peng,¹ R. Najjar,¹ E. Huang,¹ M. Toyota,⁵ X. Zhang,⁴ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Paris Transplant Group, University Paris Descartes, Paris, France; ³Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ⁴Department of HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ⁵Transplant Immunology Lab, Cedars-Sinai Medical Center, Los Angeles, CA
Introduction: DSAs in HS pts lead to poor allograft survival & return to a dialysis. Treatment options for CABMR and TG are limited. IL-6 appears…
2017 American Transplant Congress
Graft Immunocomplex Capture Fluorescence Analysis to Detect Donor Specific Antibodies and HLA Antigen Complexes in the Renal Allograft.
T. Nakamura,¹ H. Ushigome,¹ K. Watabe,² Y. Imanishi,² S. Harada,¹ S. Nobori,¹ K. Masuda,¹ N. Yoshimura.¹
¹Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan; ²Department of Blood Transfusion and Cell Therapy, Kyoto Prefectural University of Medicine, Kyoto, Japan
Background: Immunocomplex Capture Fluorescence Analysis (ICFA) is an attractive method to detect donor specific anti-HLA antibodies (DSA) and HLA antigen complexes. Currently, antibody-mediated rejection (AMR)…
2017 American Transplant Congress
Inhibition of Bruton Tyrosine Kinase Blocks Sensitization in Response to Allogeneic Skin Transplantation and Prolong Skin Graft Survival.
N. Datta, T. Palumbo, J. Kupiec-Weglinski, A. Zarrinpar.
Surgery, University of California, Los Angeles, CA
Antibody mediated rejection and donor specific antibodies are important causes of both early (hyperacute) and late (chronic) graft loss. Bruton tyrosine kinase (Btk) is required…
2017 American Transplant Congress
Novel Insights into the Synergism of CD40 Autoantibodies and suPAR in Kidney Transplant Patients with FSGS Recurrence.
T. Sigdel, C. Wei, F. Vencenti, J. Reiser, M. Sarwal.
University of California San Francisco, San Francisco
Background: FSGS is a histopathological lesion that has a 40-80% risk of recurrence o in the transplanted (tx) kidney, with increased risk of graft loss.…
2016 American Transplant Congress
IgM Donor Specific Antibodies Are Frequently Associated with C1q-binding DnDSA in Renal Transplant Recipients.
J. Bamoulid,³ A. Roodenburg,⁴ O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹
¹Nephrologie, Charite Universität Medizin, Berlin, Germany; ²HLA Labor, Charite Universität Medizin, Berlin, Germany; ³Nephrologie, CHU Jean Minjoz, Besançon, France; ⁴Erasmus Medical Centre, Rotterdam, Netherlands.
Background: Recently, the importance of complement-binding de novo DSA (dnDSA) was documented. We aimed to explore the presence of IgM dnDSA according to C1q dnDSA-binding…
2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
B. Motyka,¹ B. Lamarche,¹ K. Labonte,¹ S. Wang,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹
¹Alberta Transplant Institute/CNTRP, University of Alberta, Edmonton, Canada; ²Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
2016 American Transplant Congress
IVIG and High Dose Steroid Treatment of Transplant Glomerulopathy Effectively Slows Progression of Loss of Renal Allograft Function.
K. Sablik,¹ C. Looman,² M. Clahsen-van Groningen,³ J. Damman,³ D. Roelen,⁴ M. van Agteren,¹ M. Betjes.¹
¹Nephrology and Transplantation, Erasmus MC University Center, Rotterdam, Netherlands; ²Biostatistics, Erasmus MC University Center, Rotterdam, Netherlands; ³Pathology, Erasmus MC University Center, Rotterdam, Netherlands; ⁴Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Introduction Transplant glomerulopathy (TG) is commonly associated with chronic antibody mediated rejection and is a major cause of late kidney allograft loss with no established…
2016 American Transplant Congress
First Clinical Experience with Belatacept in 3 Hand Transplanted Patients.
J. Grahammer,¹ B. Zelger,² B. Zelger,³ M. Ninkovic,¹ A. Muehlbacher,⁴ D. Oefner-Velano,¹ S. Schneeberger,¹ A. Weissenbacher.⁵
¹Viceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; ³Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁴Department of Blood Group Serology and Transfusion Medicine, Innsbruck Medical University, Innsbruck, Austria; ⁵Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.
Study purposeBelatacept (CTLA4Ig) is an emerging treatment in solid organ transplantation. Effects on the development of donor specific antibodies (DSA) as well as its clinical…
2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
A. Haririan,¹ M. Chaudhry,² J. Papadimitriou,² N. Costa,¹ B. Thomas,¹ M. Mavanur,¹ R. Ugarte,¹ C. Cangro,¹ C. Drachenberg.²
¹Dept of Medicine, Unniversity of Maryland, Baltimore, MD; ²Dept of Pathology, University of Maryland, Baltimore, MD.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
2016 American Transplant Congress
Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies.
J. He,¹ Z. Pan,¹ X. Yuan,¹ Y. Li,¹ X. Wu,² W. Zhu,² X. Bao,¹ Q. Zhao.²
¹Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; ²Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
The NMDP and CIBMTR provided guidelines for the use of anti-HLA antibodies in unrelated-donors hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other…