2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…2017 American Transplant Congress
IgG Antibody Subclasses in Potential Renal Transplant Recipients with DSA, AHG-CDC CxM Negative and FxM Positive or Negative with Their Potential Donors.
Background. In kidney transplant recipients, IgG3 and IgG4 DSA have been associated with shorter time to acute AMR and with later allograft injury (glomerulopathy &…2017 American Transplant Congress
De Novo Malignancy Occurrence After Kidney Transplantation in HLA-Sensitized Patients Treated with B-Cell Targeting Therapy.
Management of high risk transplantations in patients with preformed DSA still remains a dilemma. Many groups propose to increase the immunosuppression in these patients by…2017 American Transplant Congress
Impact of Immunosuppression Adherence on De Novo Donor-Specific Antibody Formation in Renal Transplant Recipients in Canada: A Modeling Analysis.
Acute rejection rates and short-term graft survival have improved substantially as a result of advances in immunosuppression (IS), though longer-term graft survival rates have improved…2016 American Transplant Congress
Urine Cell-Free Supernatant Metabolites Diagnostic of Antibody Mediated Rejection in Kidney Allografts.
1Weill Cornell Medicine, NY; 2Weill Cornell Medical College-Qatar, Doha, Qatar.
Introduction:Urine cell-free supernatant metabolite profiles provide a unique opportunity to interrogate intra-graft processes and have distinguished acute cellular rejection from no rejection in the Clinical…2016 American Transplant Congress
Bone Allograft: An Unusual Cause of Sensitization.
We report the case of a 33 year-old female patient who started hemodialysis in 2009 because of end stage renal disease of unknown etiology. When…2016 American Transplant Congress
Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).
1Nephrology, LUMC, Leiden, Netherlands; 2IHB, LUMC, Leiden, Netherlands.
Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…2016 American Transplant Congress
Optimal Integration of Kidney Exchange Programs with Antibody Reduction Therapy to Increase Successful Transplant in Difficult to Match Recipients.
Kidney paired donation (KPD) allows incompatible pairs to exchange kidneys with other incompatible pairs. However, evidence suggests there stills exist barriers to KPD utilization, especially…2016 American Transplant Congress
Monitoring of De Novo DSA Post Alemtuzumab Induction in Renal Transplant Recipients: One Year Follow Up.
Nephrology & Hypertension, Stony Brook Medicine, Stony Brook, NY.
IntroductionThe presence of de novo DSA (dnDSA) is associated with antibody mediated rejection and less optimal graft outcomes. The overall incidence of dnDSA post renal…2016 American Transplant Congress
Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.
Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
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