Articles tagged "Antibodies"

2022 American Transplant Congress
Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft
D. Okada, S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. Baldwin, R. Fairchild
Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…
2022 American Transplant Congress
High Resolution Typing Can Improve Accuracy and Sensitivity of the Virtual Crossmatch for Sensitized Patients – A Single Center’s Experience
C. MarElia-Bennett¹, V. Rohan², K. Twombley³, O. Moussa¹
¹Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, ²Surgery, Medical University of South Carolina, Charleston, SC, ³Medical University of South Carolina, Charleston, SC
*Purpose: The introduction of solid phase assays has significantly enhanced our ability to execute virtual crossmatches (VXMs). However, this method is not without its shortcomings.…
2022 American Transplant Congress
Correlation of Non-HLA Antibodies and Biopsy-Proven Antibody-Mediated Rejection
N. Patel, M. Kittleson, J. Patel, T. Singer-Englar, S. Kim, D. Chang, E. Kransdorf, D. Megna, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Non-HLA antibodies are seen in heart transplantation (HTx), but the clinical significance has not been established. In many cases, non-HLA antibodies are drawn, but…
2022 American Transplant Congress
Outcomes of Highly-Sensitized, Virtual and Flow Cross-Match Negative Renal Transplant Recipients: A Retrospective Observational Study
A. Agrawal¹, B. Smith¹, M. Gandhi², C. Schinstock¹
¹Transplant Nephrology, Mayo Clinic, Rochester, MN, ²Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Many highly-sensitized kidney transplant recipients are sensitized from prior transplants, which have been shown to limit graft survival more than pregnancy or blood transfusions.…
2022 American Transplant Congress
Pre-Transplant Vaccine Induced SARS-CoV-2 Antibodies Decrease Following Induction Therapy for Kidney Transplantation
N. Barros¹, A. C. Ermel¹, A. Sharfuddin², W. Goggins³, J. Fridell²
¹Indiana University, Indianapolis, IN, ²Indiana University School of Medicine, Indianapolis, IN, ³Indiana University Hospital, Indianapolis, IN
*Purpose: Kidney transplant recipients (KT) and wait-listed individuals exhibit an impaired response to vaccinations. There is currently no data on the impact of induction immunosuppression…
2022 American Transplant Congress
Kinetics and Durability of a Third Dose of Sars-cov-2 Vaccination Among Solid Organ Transplant Recipients
T. P. Chiang, J. Alejo, J. Mitchell, A. Abedon, L. Zeizer, J. Kim, L. Thomas, D. Segev, W. Werbel, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose: Understanding the dynamics of antibody response to a third dose (D3) of anti-SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) is important to inform…
2022 American Transplant Congress
Validation of Donor Specific Antibody Characteristics Associated with Deleterious Outcomes: A Single Center Study of 940 Kidney Allograft Recipients
P. Lamba¹, I. Lamba¹, R. Friedlander², V. Sharma³, J. Lee², J. B. Lee⁴, C. Hartono⁵, M. Thangamani⁶, D. Sawinski², T. Salinas⁷, M. Suthanthiran⁸, D. Dadhania⁹
¹Nephrology, Hypertension and Transplantation, New York Presbyterian/Weill Cornell Medicine, New York, NY, ²New York Presbyterian/Weill Cornell Medicine, New York, NY, ³The Rogosin Inst Cornell UMC, New York, NY, ⁴Rogosin Institute, New York, NY, ⁵New York Presbyterian Hospital-Weill Cornell, New York, NY, ⁶Cornell, New York, NY, ⁷Nephrology, NY Presbyterian- Weill Cornell, New York, NY, ⁸Weill Cornell Med Ctr., New York, NY, ⁹Weill Cornell Medicine - NYPH, New York, NY
*Purpose: A reproducibility crisis is pervasive in scientific literature. We aimed to investigate whether the DSA characteristics we previously associated with antibody mediated rejection (AMR)…
2022 American Transplant Congress
Evaluation of Post-Transplant Angiotensin II Type 1 Receptor Antibodies, Donor-Derived Cell-Free DNA, and Rejection in Heart Transplant Recipients
B. Agegnehu¹, S. Sterling¹, R. Winstead¹, I. Tchoukina²
¹Pharmacy, VCU Health System, Richmond, VA, ²Advanced Heart Failure and Transplant Cardiology, VCU Health System, Richmond, VA
*Purpose: There is limited evidence evaluating the relationship between angiotensin II type 1 receptor antibodies (AT1R-Abs), donor-derived cell-free DNA (dd-cfDNA), and rejection in heart transplant…
2022 American Transplant Congress
De Novo Anti-Brush Border Antibody Disease in a Kidney Transplant Recipient
P. Yenebere, D. Ibrahim, T. Nadasdy, R. Daloul
Ohio State University, Columbus, OH
*Purpose: Anti-brush border antibody (ABBA) disease is very rare, characterized by tubulointerstitial damage caused by autoantibodies against LDL receptor-related protein 2 (LRP2) in the proximal…
2022 American Transplant Congress
How Does Anti-CD38 Antibody Treatment (Daratumumab) Impact Immunological Assessment in Solid Organ Transplantation?
S. Ho¹, K. Putnam², C. Peiter², W. Herczyk², J. Gerlach³, E. Campagnaro⁴, Y. Lu⁴, K. Woodside⁴, M. Cusick⁴
¹Gift of Hope Organ & Tissue Donor Network, Itasca, IL, ²Gift of Life Michigan, Ann Arbor, MI, ³Michigan State University, East Lansing, MI, ⁴University of Michigan Medicine, Ann Arbor, MI
*Purpose: We report the first case of Dara interference of routine pre-transplant (Tx) crossmatch (XM) repeatedly causing aberrant false positives which inadvertently delayed Tx for…