Articles tagged "Antibodies"

2022 American Transplant Congress
Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Practice Patterns, Report from the Paramour “Pediatric Renal AMR Outcomes” Study
N. Hayde¹, K. Twombley², I. Ashoor³, R. Engen⁴, L. Harshman⁵, R. Zahr⁶, C. Peterson⁷, S. McEwen⁸, A. Jain⁹, R. Garro¹⁰, M. Kallash¹¹, A. Mansuri¹², D. Puliyanda¹³
¹Montefiore Medical Center, Bronx, NY, ²Medical University of South Carolina, Charleston, SC, ³LCMCHealth, New Orleans, LA, ⁴Pediatrics, University of Wisconsin Madison, Madison, WI, ⁵University of Iowa Children's Hospital, Iowa City, IA, ⁶Le Bonheur Children's Hospital, Nashville, TN, ⁷University of Utah, Salt Lake City, UT, ⁸University of Minnesota, Minneapolis, MN, ⁹Wayne State, Troy, MI, ¹⁰Emory Universtiy, Atlanta, GA, ¹¹The Ohio State, Columbus, OH, ¹²Augusta University Medical Center, Augusta, GA, ¹³Cedars-Sinai Med Ctr, West Hollywood, CA
*Purpose: There is insufficient data on children with AMR in the literature, and the optimal therapy for AMR is not well defined. We aim to…
2022 American Transplant Congress
Obinutuzumab in Kidney Transplantation: Effect on B-cell Counts and Crossmatch Tests
M. M. Nasrallah¹, M. Elalfy¹, Y. Elmesseery², I. Amer¹, P. Malvezzi³, L. Rostaing⁴
¹Misr International Hospital, Cairo, Egypt, ²Misr International Hospital, Caire, Egypt, ³CHU Grenoble-Alpes, Grenoble, France, ⁴Service de Néphrologie, CHU Grenoble-Alpes, Grenoble, France
*Purpose: Resistance to the action of rituximab (RTX), has been documented in several diseases. More recently, obinutuzumab (OBZ) has shown promise where RTX has failed…
2022 American Transplant Congress
Effects of Race, Previous CoV2 Exposure and the Length and Type of Maintenance Immunosuppression on Protective Immunity to COVID19 Vaccine in Solid Organ Transplant Recipients
A. Choudhary¹, M. Lerman², S. Khan², J. Hunt², A. Nikaein³, D. Calianese¹, E. Kalu², D. K. Jaijyan⁴, W. Honnen¹, A. Pinter¹
¹PHRI, Rutgers University, Newark, NJ, ²Transplant, Medical City Dallas, Dallas, TX, ³Texas Speciality, Medical City Dallas, Dallas, TX, ⁴pHRI, Rutgers University, Newark, NJ
*Purpose: The diverse factors affecting the vaccine induced neutralizing antibody response in solid organ transplant recipients and their immunity against CoV2 variants are needed to…
2022 American Transplant Congress
Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort
S. B. See¹, X. Yang², C. Burger³, B. Lamarthée⁴, R. Snanoudj⁵, R. Shihab¹, D. S. Tsapepas⁶, P. Roy¹, S. Larivière-Beaudoin⁷, K. Hamelin⁷, A. Mendoza Rojas⁸, N. M. van Besouw⁸, A. Bartosic⁹, N. Daniel⁹, E. R. Vasilescu¹⁰, S. Mohan¹¹, D. Cohen¹¹, L. Ratner¹¹, C. C. Baan⁸, J. S. Bromberg⁹, H. Cardinal⁷, D. Anglicheau³, Y. Sun², E. Zorn¹
¹CCTI, Columbia University Irving Medical Center, New York, NY, ²Biostatistics, Columbia University Irving Medical Center, New York, NY, ³Necker Hospital, Paris, France, ⁴Necker-Enfants Malades Institute, Paris, France, ⁵Bicêtre Hospital, Paris, France, ⁶Surgery, Columbia University Irving Medical Center, New York, NY, ⁷CHUM, Montreal, QC, Canada, ⁸Erasmus MC, Rotterdam, Netherlands, ⁹Surgery, University of Maryland School of Medicine, Baltimore, MD, ¹⁰Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ¹¹Medicine, Columbia University Irving Medical Center, New York, NY
*Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…
2022 American Transplant Congress
Transplant Patients Risk for SARS-CoV-2 Infection Post-2nd Vaccine Dose; We Are Not Home and Dry Yet
G. Koimtzis¹, L. Szabó¹, P. Nagaraja¹, C. Chalklin¹, D. Elker², A. Asderakis¹
¹Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, ²Cardiff Transplant Unit, University Hosptal of Wales, Cardiff, United Kingdom
*Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. Data of transplant patients’ infections post-2nd vaccine dose is not available. The aim of the…
2022 American Transplant Congress
HLA-DR/DQ Single Molecule Eplet Mismatch and Formation of De Novo Donor-Specific Anti-HLA Antibodies After Kidney Transplantation in Children
V. K. Sigurjonsdottir¹, K. Piburn¹, P. C. Grimm¹, B. M. Zhang²
¹Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, ²Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA
*Purpose: The advances in HLA typing methods and elucidation of three-dimensional molecular structures of HLA antigens in recent years have allowed analysis of donor/recipient HLA…
2022 American Transplant Congress
An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients
A. Asderakis¹, U. Khalid¹, G. Koimtzis¹, M. Ponsford², L. Szabó¹, L. Grant², S. Jolles², I. Humphreys³
¹Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, ²Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, ³Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
*Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
2022 American Transplant Congress
Antibody Response to Sars-CoV-2 Vaccine Among Kidney Transplant Recipients: A Retrospective Cohort Study
H. Ishida¹, K. Unagami², K. Ishii³, T. Kanzawa², T. Yagisawa⁴, K. Tanabe², M. Furusawa²
¹Tokyo Women's, Tokyo, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Tokyo Wimen's Medical University, Tokyo, Japan, ⁴Department of Urology, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: We examined a positivity of corona virus antibody in kidney transplant recipients who received two-doses BNT162B2 (mRNA) vaccination during the beginning 6 months in…
2022 American Transplant Congress
Circulating Antibodies in CMV Viremia in Kidney Transplantation
T. Sigdel¹, P. Velpurisiva¹, V. Dharnidharka², M. M. Sarwal¹
¹UCSF, San Francisco, CA, ²Washington University in St. Louis, Saint Louis, MO
*Purpose: Role of circulating antibodies (Abs) in graft injury outcomes of kidney transplant is reported by us and others. Cytomegalovirus (CMV) is known to contribute…
2022 American Transplant Congress
Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV
M. Saksena¹, G. Carrara², B. Haydel², A. Azad¹, K. Srivastava¹, C. Gleason¹, K. Beach¹, L. Sominsky¹, A. Oostenink¹, G. Cai¹, J. Carreno Quiroz¹, G. Singh¹, S. Florman², C. Cordon-Cardo³, J. Aberg⁴, A. Wajnberg⁵, F. Krammer¹, V. Simon¹, M. Rana⁴
¹Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, ³Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…