2017 American Transplant Congress
Improving Donor Screening for Cytomegalovirus (CMV): Is CMV IgG Avidity Better Than CMV IgM?
Study purpose: It is standard practice to test organ donors for CMV IgM as a marker of recent CMV infection (defined as primary infection within…2017 American Transplant Congress
Triptolide Alleviating Acute Antibody Mediated Rejection by Inhibition of B Cell Activation in Presensitized Recipients.
Backgroud: Acute antibody mediated rejection (AMR), resistant to most anti-rejection therapy, is main cause for renal graft loss. Triptolide(TPL) had been reported as a promising…2017 American Transplant Congress
Even Non-Donor-Specific HLA-Antibodies Are Associated with a Progressive Decline in Kidney Transplant Function.
University Spital Zuerich, Zuerich, Switzerland
Donor-specific anti-HLA-Antibodies (DSA) have been shown to be associated with antibody-mediated rejection episodes and a poorer long-term kidney graft function. The impact of anti-HLA-antibodies without…2017 American Transplant Congress
TACI Polymorphisms Associated with De Novo Alloantibodies in Humans and Allograft Rejection in Mice.
A. Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants among healthy individuals and individuals with…2017 American Transplant Congress
Differential Effects of the Novel ATP-Competitive mTOR Inhibitor (TORKinib) AZD2014 and Rapamycin on Alloimmunity and Transplant Survival.
Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA
Background: Rapamycin (RAPA), is an immunosuppressive agent that inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and…2017 American Transplant Congress
Elevated Circulating AT1R Levels Indicate Heightened Risk for Antibody Mediated Rejection and Graft Failure.
Transplant Surgery, VCUHealth Systems, Richmond, VA
Background.Antibody(Ab) against the angiotensin II receptor(AT1R) can cause antibody mediated rejection(AMR) and graft failure after transplantation. We evaluated whether circulating AT1R is a potential marker…2017 American Transplant Congress
Measles Screening and Vaccination in Solid Organ Transplant Recipients: Adherence to Infectious Disease Community of Practice (IDCOP) Recommendations.
1Infectious Disease, Cleveland Clinic, Cleveland; 2Statistics, Cleveland Clinic, Cleveland
Background: Measles is a highly contagious viral infection that rarely affects transplant recipients. Cases remain in the United States due to vaccine refusal and importation…2017 American Transplant Congress
Improved Mouse Renal Transplantation Model Simulating Clinical Antibody Mediated Rejection.
Background: Acute antibody mediated rejection (AMR) is main barrier to long term renal graft survival. Mouse model is important to understand the mechenisms of AMR.…2017 American Transplant Congress
It's Never too Early to Test: Frequent Anti-A2 Titer Monitoring in Blood Group B Patients is Necessary.
Medstar Georgetown Transplant Institute, Washington, DC
Introduction:With the implementation of the new Kidney Allocation System (KAS), deceased donor transplants from blood group A2 donors can now be implanted into blood group…2017 American Transplant Congress
Precise Antibody Characterization Using Multiple Solid Phase Assay Platforms Is Critical for Accurate Virtual Crossmatching.
Purpose: Virtual crossmatch (VXM) has been utilized in heart transplant (txp) for more than a decade. Many labs base the VXM solely on single antigen…
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