2017 American Transplant Congress
HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.
Pathology, Loyola University Medical Center, Maywood, IL
Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…2017 American Transplant Congress
False-Positive Flow Cytometric Crossmatch Results and the Utility of the Virtual Crossmatch.
Pathology, University of Chicago Medicine, Chicago, IL
Introduction: A negative crossmatch (XM) is critical for solid organ allocation. Flow cytometric XM (FCXM) is more sensitive than complement-dependent cytotoxicity XM (CDC-XM), and has…2017 American Transplant Congress
Blood Transfusion Induced Donor Specific Antibodies Are Associated with Rejection and Graft Failure.
Introduction: Although it is well known that blood transfusions post-transplant are associated with the development of both HLA and donor specific antibodies [DSAs] and a…2017 American Transplant Congress
Comprehensive Functional Assessment of the Pathogenic Potential of Immunodominant Donor Specific Antibody Following Treatment of Late Antibody Mediated Rejection or Mixed Acute Rejection.
1U of Cincinnati, Cincinnati; 2Christ Hospital, Cincinnati
HLA donor specific antibody (DSA) mediates injury by both complement dependent and independent mechanisms, including direct signaling via HLA antigens and via Fc receptor (FcR)…2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…2017 American Transplant Congress
A Lower Mean Exposure to Tacrolimus, Not Intra-Patient Variability Is Associated with Chronic Active Antibody Mediated Rejection.
Introduction. Chronic active antibody mediated rejection (caABMR) is one of the major causes of long-term kidney graft loss. It is hypothesized that frequent underexposure and…2017 American Transplant Congress
ABO Incompatible Deceased Donor Renal Transplantation: Exploring the Possibilities.
Background: There is significant variation in waiting times for deceased donor (DD) renal transplants based on recipient blood group. Furthermore, there is an increased discard…2017 American Transplant Congress
Inflammatory Cytokines Are Associated with Angiotensin II Type 1 Receptor Antibodies and Vascular Inflammation in Pediatric Renal Transplantation.
1University of California, Los Angeles, CA; 2Duke University, Durham, NC
Background: We recently found that angiotensin II type 1 receptor antibody (AT1R-Ab) was associated with decreased renal function in pediatric renal transplant recipients independent of…2017 American Transplant Congress
Generation of Natural Antibodies Post Transplant and Association with Kidney Allograft Loss.
The development of donor specific antibodies (DSA) reacting to mismatched donor class I and class II HLA is a prominent risk factor for kidney graft…2017 American Transplant Congress
Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.
Mayo Clinic Arizona, Phoenix, AZ
Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…
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