2018 American Transplant Congress
Long-Term Success of Treatment for Cardiac Transplant AMR May Depend Upon Suppressing Class II Donor Specific Antibodies
Antibody mediated rejection (AMR) in cardiac transplant (tspt) patients (pts) is primarily mediated by donor specific antibodies (DSAs) and associated with reduced long-term graft survival.…2018 American Transplant Congress
Further In Vivo and In Vitro Evidence That Anti-CD40 MABS Do Not Induce Thromboembolism
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Clinical trials with non-silenced anti-CD40L (anti-CD154) monoclonal antibodies (mAb) in patients with systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP) were halted after unexpected…2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
1University of California, Los Angeles, Los Angeles, CA; 2Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…2018 American Transplant Congress
Long Term Outcomes of Renal Allografts with De Novo DSA in the Setting of Stable Graft Function versus Acute Rejection
We sought to compare the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function versus dnDSA…2018 American Transplant Congress
Eculizumab for the Treatment of Antibody Mediated Rejection in Kidney Transplant Recipients: A Single Center Experience
Pharmaceutical Services, UCSF Medical Center, San Francisco, CA.
BACKGROUND: Antibody mediated rejection (ABMR) accounts for 20-30% of acute rejection episodes and can affect long-term renal allograft survival. The complement system plays an active…2018 American Transplant Congress
IVIG Induction May Be Helpful in Highly Sensitized Patients after Heart Transplantation
Cedars Sinai Medical Center, Los Angeles.
Purpose: Strategies for sensitized patients undergoing heart transplant include post-op anti-thymocyte globulin (ATG) induction therapy as well as intravenous immunoglobulin (IVIG). We sought to assess…2018 American Transplant Congress
Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection
Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…2018 American Transplant Congress
Donor-Specific B-Cell Tolerance after Successful ABO Blood Type Incompatible (ABOi) Living Donor Liver Transplantation (LDLT)
Background/purposeABO blood type-incompatible (ABOi) liver transplantation is one of the strategies employed to overcome the shortage of donor. By using the Rituximab and plasm exchange,…2018 American Transplant Congress
Humoral Immune Response to Seasonal Influenza Infection in Transplant Recipients
Background: Little is known about the serologic response to natural influenza infection in transplant recipients. We describe the hemagglutinin antibody response to influenza A/H1N1 infection…2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…
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