2018 American Transplant Congress
Lower Incidence of De Novo Donor-Specific Antibodies against HLA-DR in ABO-Incompatible Renal Transplantation
IntroductionDe novo DSA-induced chronic antibody-mediated rejection (AMR) is one of major obstacles to long term graft survival. We have reported that anti-A/B antibody binding could…2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…2018 American Transplant Congress
Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival
Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…2018 American Transplant Congress
False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation
Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…2018 American Transplant Congress
FSGS Pattern with Podocyte Proliferation and Heavy Proteinuria Combined Late Antibody Mediated Rejection of Renal Allograft: Collapsing Glomerulopathy or Transplant Podocytopathy?
Background: Collapsing Glomerulopathy is a pathologically and clinically distinct variant of FSGS with poor prognosis.Hemodynamic disturbances may play a role in the development of the…2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Regulatory Proteins in Lung Transplant Recipient with Primary Graft Dysfunction
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Background: Circulating exosomes isolated from lung transplant recipients (LTxRs) with acute or chronic rejection contains lung self-antigens (SAgs), K alpha 1 tubulin (Kα1T) and collagen…2018 American Transplant Congress
Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation by Blood Expression of Genes Involved in IFN Signaling
Purpose: Antibody-mediated rejection (ABMR) has been recognized as a major cause of graft loss. Early diagnosis and effective treatment are crucial for salvaging grafts undergoing…2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…2018 American Transplant Congress
Early Conversion to a CNI-Free Immunosuppression with SRL after Renal Tx – 10 yr Follow-Up Analysis of a Prospective Multicenter Trial
Introduction: A prospective multicenter trial comparing an early conversion to a CNI-free immunosuppression with SRL, MMF and steroids with a conventional CsA treatment following renal…
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