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Articles tagged "Antibodies"

  • 2018 American Transplant Congress

    Lower Incidence of De Novo Donor-Specific Antibodies against HLA-DR in ABO-Incompatible Renal Transplantation

    M. Okada,1 K. Futamura,1 T. Hiramitsu,1 M. Tsujita,1 N. Goto,1 S. Narumi,1 Y. Watarai,1 K. Iwasaki,2 T. Kobayashi.2

    1Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; 2Department of Transplant Surgery, Aichi Medical University, Nagakute, Japan.

    IntroductionDe novo DSA-induced chronic antibody-mediated rejection (AMR) is one of major obstacles to long term graft survival. We have reported that anti-A/B antibody binding could…
  • 2018 American Transplant Congress

    Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation

    P. Jindra, M. Kueht, S. Gray, D. Giang, M. Cusick, A. Rana, B. Murthy, W. Etheridge, J. Goss, R. Kerman.

    Division of Abdominal Transplantation and Hepatobiliary Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.

    Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…
  • 2018 American Transplant Congress

    Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival

    S. Kodali,1 H. Sandoval,1 M. Chen,2 J. Wang.1

    1Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; 2Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.

    Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
  • 2018 American Transplant Congress

    False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation

    D. Iwami,1 M. Ito,2 K. Hotta,1 H. Higuchi,1 N. Shinohara.1

    1Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan; 2Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.

    Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…
  • 2018 American Transplant Congress

    Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection

    D. Zhao,1 T. Liao,1 S. Li,1 J. Zhou,2 F. Han,1 Y. Dong,3 Q. Sun.1

    1Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; 3Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…
  • 2018 American Transplant Congress

    FSGS Pattern with Podocyte Proliferation and Heavy Proteinuria Combined Late Antibody Mediated Rejection of Renal Allograft: Collapsing Glomerulopathy or Transplant Podocytopathy?

    J. Wen, M. Zhang, F. Xu, J. Chen, D. Cheng, X. Ni, X. Li.

    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.

    Background: Collapsing Glomerulopathy is a pathologically and clinically distinct variant of FSGS with poor prognosis.Hemodynamic disturbances may play a role in the development of the…
  • 2018 American Transplant Congress

    Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immune Regulatory Proteins in Lung Transplant Recipient with Primary Graft Dysfunction

    M. Sharma, S. Biswas Roy, R. Walia, A. Omar, R. Bremner, M. Smith, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.

    Background: Circulating exosomes isolated from lung transplant recipients (LTxRs) with acute or chronic rejection contains lung self-antigens (SAgs), K alpha 1 tubulin (Kα1T) and collagen…
  • 2018 American Transplant Congress

    Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation by Blood Expression of Genes Involved in IFN Signaling

    M. Matz,1 Q. Zhang,1 F. Heinrich,2 C. Lorkowski,1 K. Wu,3 P. Durek,2 N. Lachmann,4 M-.F. Mashreghi,2 K. Budde.1

    1Nephrology, University Medicine Charité Berlin, Berlin, Germany; 2Drfz, Berlin, Germany; 3Pathology, University Medicine Charité Berlin, Berlin, Germany; 4Center For Tumor Medicine, H&I Laboratory, University Medicine Charité Berlin, Berlin, Germany.

    Purpose: Antibody-mediated rejection (ABMR) has been recognized as a major cause of graft loss. Early diagnosis and effective treatment are crucial for salvaging grafts undergoing…
  • 2018 American Transplant Congress

    Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease

    M. Sharma, W. Liu, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.

    Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
  • 2018 American Transplant Congress

    Early Conversion to a CNI-Free Immunosuppression with SRL after Renal Tx – 10 yr Follow-Up Analysis of a Prospective Multicenter Trial

    J. Andrassy,1 M. Guba,1 A. Habicht,2 M. Fischereder,3 A. Pascher,4 K. Heller,5 B. Banas,6 O. Hakenberg,7 T. Vogel,8 T. Kauke.1

    1Surgery, Ludwig-Maximilans-University, Munich, Germany; 2Transplant, Ludwig-Maximilans-University, Munich, Germany; 3Nephrology, MED IV, Ludwig-Maximilans-University, Munich, Germany; 4Surgery, Charitée University, Berlin, Germany; 5Medicine, University of Erlangen, Erlangen, Germany; 6Internal Medicine II, University of Regensburg, Regensburg, Germany; 7Urology, University of Rostock, Rostock, Germany; 8Surgery, University of Munster, Munster, Germany.

    Introduction: A prospective multicenter trial comparing an early conversion to a CNI-free immunosuppression with SRL, MMF and steroids with a conventional CsA treatment following renal…
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