Articles tagged "Antibodies"

2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
M. Sharma, W. Liu, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
2018 American Transplant Congress
Early Conversion to a CNI-Free Immunosuppression with SRL after Renal Tx – 10 yr Follow-Up Analysis of a Prospective Multicenter Trial
J. Andrassy,¹ M. Guba,¹ A. Habicht,² M. Fischereder,³ A. Pascher,⁴ K. Heller,⁵ B. Banas,⁶ O. Hakenberg,⁷ T. Vogel,⁸ T. Kauke.¹
¹Surgery, Ludwig-Maximilans-University, Munich, Germany; ²Transplant, Ludwig-Maximilans-University, Munich, Germany; ³Nephrology, MED IV, Ludwig-Maximilans-University, Munich, Germany; ⁴Surgery, Charitée University, Berlin, Germany; ⁵Medicine, University of Erlangen, Erlangen, Germany; ⁶Internal Medicine II, University of Regensburg, Regensburg, Germany; ⁷Urology, University of Rostock, Rostock, Germany; ⁸Surgery, University of Munster, Munster, Germany.
Introduction: A prospective multicenter trial comparing an early conversion to a CNI-free immunosuppression with SRL, MMF and steroids with a conventional CsA treatment following renal…
2018 American Transplant Congress
The Role of Donor-Derived Cell-Free DNA in Identification of Injury in Kidney Allografts with Antibody-Mediated Rejection and De Novo DSA
H. Zhang,¹ L. Liu,¹ C. Zheng,² X. Li,¹ Q. Fu,¹ J. Li,¹ Q. Su,¹ H. Huang,¹ M. Ye,² C. Wang.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; ²BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, Guangzhou, China.
Objectives: To evaluate the capacity of donor-derived cell-free DNA (dd-cfDNA) in the identification of injury in kidney allografts with antibody-mediated rejection and de novo DSA.Methods:…
2018 American Transplant Congress
Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss
R. Sapir-Pichhadze,¹ X. Zhang,¹ A. Ferradji,¹ A. Madbouly,² S. Fingerson,² K. Tinckam,⁵ H. Gebel,³ H. Cardinal,⁴ B. Foster.¹
¹McGill University, Montreal, Canada; ²National Marrow Donor Program, Minneapolis; ³Emory University Hospital, Atlanta; ⁴CHUM, Montreal, Canada; ⁵University Health Network, Toronto, Canada.
Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…
2018 American Transplant Congress
Protocolar Biopsies in Patients with Subclinical De Novo DSA in Kidney Transplantation
D. Bertrand,¹ M. Jaureguy,² C. Garrouste,³ J. Sayegh,⁴ N. Bouvier,⁵ S. Caillard,⁶ L. Lanfranco,⁷ A. Galinier,⁸ A. François,⁹ F. Hau,¹⁰ I. Etienne,¹ P. Gatault.¹¹
¹Nephrology Kidney Transplantation Dialysis, CHU Rouen, Rouen, France; ²Nephrology Kidney Transplantation, CHU Amiens, Amiens, France; ³Nephrology Kidney Transplantation, CHU Clermont Ferrand, Clermont Ferrand, France; ⁴Nephrology Kidney Transplantation, CHU Angers, Angers, France; ⁵Nephrology Kidney Transplantation, CHU Caen, Caen, France; ⁶Nephrology Kidney Transplantation, CHU Strasbourg, Strasbourg, France; ⁷Nephrology Kidney Transplantation, CHU Brest, Brest, France; ⁸Nephrology Kidney Transplantation, CHU Poitiers, Poitiers, France; ⁹Pathology, CHU Rouen, Rouen, France; ¹⁰EFS Normandie, EFS Normandie, Rouen, France; ¹¹Nephrology Kidney Transplantation, CHU Tours, Tours, France.
De novo donor-specific antibody (DSA) is associated with antibody-mediated rejection (ABMR) and allograft loss. The aim of our study was to examine the histology associated…
2018 American Transplant Congress
Peripheral but Not Follicular T Helper Cells Are Activated by Allogeneic Human Endothelial Cells under IRI-Like Conditions and Promote Donor Specific Antibody
W. Fu,¹ P. Yoo,² J. Pober,³ D. Jane-wit.¹
¹Cardiovascular Medicine, Yale School of Medicine, New Haven, CT; ²Surgery, Yale School of Medicine, New Haven, CT; ³Immunobiology, Yale School of Medicine, New Haven, CT.
Background: Perioperative ischemia reperfusion injury (IRI) is a consequence of solid organ allograft transplantation that primes the graft for future rejection.Methods: We developed an in…
2018 American Transplant Congress
The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels
Y. Jung,¹ D. Kim,¹ J. Lee,¹ S. Song,² J. Lee,³ B. Kim,⁴ J. Lee,¹ S. Kim,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; ⁴Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the…
2018 American Transplant Congress
Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates
T. Blydt-Hansen,¹ W. Klement,² K. Tinckam,³ J. Gill.¹
¹University of British Columbia, Vancouver, Canada; ²Canadian Blood Services, Ottawa, Canada; ³University of Toronto, Toronto, Canada.
Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…
2018 American Transplant Congress
Treatment of Active Chronic Antibody-Mediated Rejection with Rituximab, IVIG and Plasma Exchange
G. Piñeiro,¹ J. Rovira,² E. De Sousa-Amorim,¹ J. Villarreal,¹ M. Sole,³ I. Revuelta,¹ M. Lozano,⁴ E. Palou,⁴ F. Oppenheimer,¹ J. Campistol,¹ F. Diekmann.^1,2
¹Nephrology and Renal Transplantation, Hospital Clinic de Barcelona, Barcelona, Spain; ²Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; ³Pathology, Hospital Clinic de Barcelona, Barcelona, Spain; ⁴Apheresis Unit, Hemotherapy and Hemostasis, Hospital Clinic de Barcelona, Barcelona, Spain; ⁵Immunology, Hospital Clinic de Barcelona, Barcelona, Spain.
Chronic antibody-mediated rejection (cABMR) and transplant glomerulopathy (TG) are main features associated with long-term graft loss. Despite its clinical significance, the available evidence on treatment…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…