Articles tagged "Antibodies"

2018 American Transplant Congress
Waning Enthusiasm for a Once Promising Test: C1q Testing Does Not Provide Prognostic Information for DSA Screening Protocols
A. Gilbert, D. Li, M. Awwad, S. Rosen-Bronson, P. Abrams, J. Verbesey, G. Vranic, M. Cooper.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Testing of donor specific antibodies (DSA) for binding of complement component C1q has been used to better elucidate pathologic antibodies from more benign reactions.…
2018 American Transplant Congress
Measles and Varicella Vaccination Status and Evidence of Immunity during Solid Organ Pre-Transplantation Evaluation
H. Daniels, C. Saracusa, S. Worley, B. Gonzalez.
Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, OH.
Background: Ensuring complete vaccination is important during a pre-transplant evaluation (PTE), especially for live viral vaccines which are generally contraindicated after transplant. After one dose…
2018 American Transplant Congress
Graft Immunocomplex Capture Fluorescence Analysis Can Detect Intra-Graft Anti-Blood Group A/B Antibodies
T. Nakamura,¹ H. Ushigome,¹ Y. Imanishi,² S. Kawai,³ T. Shirouzu,³ M. Osaka,¹ K. Masuda,¹ T. Matsuyama,¹ S. Harada,¹ S. Nobori,¹ N. Yoshimura.¹
¹Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan; ²Department of Blood Transfusion and Cell Therapy, Kyoto Prefectural University of Medicine, Kyoto, Japan; ³Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Led, Hiroshima, Japan.
Background: Graft immunocomplex capture fluorescence analysis (ICFA) is an attractive method to detect intra-graft donor-specific anti-HLA antibodies (HLA-DSA). In ABO incompatible (ABOi) transplantation, anti-A/B antibodies…
2018 American Transplant Congress
The Utility of a CD31/CD68 Dual Immunohistochemical Stain to Improve Accurate Diagnosis of Antibody Mediated Rejection in Cardiac Transplantation
C. Glass, Y. Butt, T. Gokaslan, J. Torrealba.
Thoracic Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Antibody mediated rejection (AMR) occurs in 10%-20% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy, used to identify microvascular injury…
2018 American Transplant Congress
Clinical Impact of Denovo or Recurrent Donor Specific Antibodies in the First Year Post Kidney Transplant in Patients on Early Steroid Withdrawal Immunosupression Regimen
O. Adebiyi, T. Taber, W. Goggins, D. Mishler, M. Yaqub, A. Sharfuddin.
Division of Renal Disease and Hypertension, Indiana University Health, Indianapolis, IN.
Background: Immunologic risk monitoring of recipients of kidney transplant(Tx) using donor specific antibodies (DSA) has become a standard practice in most Tx centers in the…
2018 American Transplant Congress
Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection
K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.
Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Ohio State University, Columbus, OH; Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Washington University, Saint Louis, MO.
Antibody mediated rejection continues to be one of the most detrimental complications of kidney transplant. Multiple therapeutic strategies focused on B cell and/or HLA antibody…
2018 American Transplant Congress
Role of Calcium/Calmodulin Kinase IV on Podocyte Function in Transplant Glomerulopathy
R. Bhargava, K. Maeda, A. Ferreti, M. Pavlakis, G. Tsokos.
Beth Israel Deaconess Medical Center, Boston.
Background : Transplant glomerulopathy(TG) a histological manifestation of chronic antibody mediated rejection and a major cause of late allograft loss. It is well accepted that…
2018 American Transplant Congress
Evaluation of Drug Action on IgM Memory B Cell Survival and Growth In Vitro; -Application for Individualized Immunosuppression after Kidney Transplants-
Y. Matsuda,¹ K. Takahashi,¹ R. Imamura,² N. Nonomura,² Y. Yuzawa.¹
¹Nephrology, Fujita Health University, Toyoake, Aichi, Japan; ²Urology, Osaka University, Suita, Osaka, Japan.
(Background)Recently, the establishment of early diagnosis and treatment methods for antibody-mediated rejection (ABMR) has garnered much attention.Strong immunosuppression including desensitization is accompanied by severe side…
2018 American Transplant Congress
Outcomes of C4d+ Immunostaining in Heart Transplantation: Is All Immunologic AMR Bad?
M. Rafiei, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, S. Mersola, G. Esmailian, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Antibody-mediated rejection (AMR) remains a threat to patients (pts) following heart transplant (HTx). C4d immunostaining is one component involved in the diagnosis of AMR…
2018 American Transplant Congress
Development of Denovo DSA after One Year Post Kidney Transplant and Clinical Outcomes in Patient on Steroid Free Immunosupression
A. Sharfuddin, M. Yaqub, D. Mishler, W. Goggins, T. Taber, O. Adebiyi.
Division of Renal Disease and Hypertension, Indiana University Health Transplant Program, Indianapolis, IN.
Background: Development of Denovo donor specific antibodies (DnDSA) has been associated with poor allograft outcomes in few studies. However, there is scarcity of data evaluating…