Articles tagged "Antibodies"

2019 American Transplant Congress
Clazakizumab (CLZ, Anti-IL-6 Monoclonal Antibody) Treatment of Patients (Pts) with Chronic Antibody-Mediated Rejection (cABMR) Reduces Total Immunoglobulin (Ig) and Anti-HLA IgG Antibody Levels
B. Shin, N. F. Ammerman, A. A. Vo, X. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have recently reported successful use of Tocilizumab (TCZ), an anti-IL-6 receptor (R) monoclonal antibody, for cABMR treatment in HLA-sensitized kidney transplant (KTx) Pts.…
2019 American Transplant Congress
Anti-cmv Antibody (cmv-ab) And Cmv-specific Cytotoxic T Cell (cmv-tc) Positivity Are Essential To Control Severe Viremia In Seronegative (sero[-]) Pediatric Kidney Transplant Recipients (ped Ktx Pts).
B. Shin, H. Pizzo, D. Puliyanda, A. Petrosyan, D. Lovato, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: CMV infection represents a significant morbidity factor in KTx Pts, especially CMV sero(-) Ped Pts as infections tend to be more severe and recurrent.…
2019 American Transplant Congress
Timing, Duration, and Source of Hepatitis C Virus (HCV) Antibodies (Ab) among HCV-Negative Recipients of an Organ from an HCV-Infected Donor
P. Porrett¹, P. Reese¹, E. Blumberg¹, P. Abt¹, R. Bloom¹, K. Reddy¹, V. Holzmayer², K. Coller², M. Kuhns², G. Cloherty², D. Goldberg¹
¹University of Pennsylvania, Philadelphia, PA, ²Abbott Labs, Chicago, IL
*Purpose: The opioid epidemic has increased the number of deceased donors with active (Ab+/NAT+) or prior (Ab+/NAT-) HCV infection. Increased utilization of these donor organs…
2019 American Transplant Congress
De Novo Complement-Activating Donor Specific Antibodies in Pediatric Renal Transplant Recipients Are Highly Responsive to Therapy
V. Sigurjonsdottir, A. Chaudhuri, P. Grimm
Pediatric Nephrology, Stanford, Los Altos, CA
*Purpose: Antibody mediated rejection remains a common cause for pediatric renal allograft loss. After recognizing that graft failure was more common in our pediatric renal…
2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, A. Bozovic¹, V. Kulasingam¹, P. Chen⁴, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹University Health Network, Toronto, ON, Canada, ²Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, ³Krembil Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
2019 American Transplant Congress
The Impact of Calcineurin Inhibitors on De Novo DSA in Primary Kidney Transplantation
T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, M. Tsujita, T. Ichimori, N. Goto, S. Narumi, Y. Watarai
Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan
*Purpose: De novo DSA was demonstrated as a cause of chronic AMR, leading to worse graft survival. New strategies to treat chronic AMR have been…
2019 American Transplant Congress
The Response to Human Papillomavirus Vaccination in Pediatric Patients before and after Kidney Transplantation
C. Nailescu¹, R. D. Nelson², K. Twombley³, P. S. Verghese⁴, A. S. Chishti⁵, M. Mills⁶, J. E. Slaven⁷, J. D. Mahan⁸, M. L. Shew¹
¹Riley Hospital for Children, Indianapolis, IN, ²Primary Children’s Hospital, Salt Lake City, UT, ³MUSC Children’s Hospital, Charleston, SC, ⁴Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, ⁵Kentucky Children’s Hospital, Lexington, KY, ⁶C.S. Mott Children’s Hospital, Ann Arbor, MI, ⁷Indiana University, Indianapolis, IN, ⁸Nationwide Children’s Hospital, Columbus, OH
*Purpose: Kidney transplant (KT) recipients have an increased incidence of malignancies, including Human Papillomavirus (HPV)-associated cancers. Thus, HPV vaccines may have an important role in…
2019 American Transplant Congress
A Step-Wise Desensitization Using Rituximab&Bortezomib Combined with Antithymocyte Globulin for Highly Sensitized Kidney Transplant Candidates
H. Ohdan, K. Ide, M. Ohira, H. Tahara, Y. Tanaka
Hiroshima University, Hiroshima, Japan
*Purpose: In highly HLA sensitized patients, both memory B and T cells responding to donor-specific HLA in addition to plasma cells secreting anti-HLA Abs are…
2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
S. Lee¹, S. Park¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn², J. Yang³
¹Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
C. Macedo¹, K. Louis¹, P. Fadakar², M. Yamada², B. Elinoff¹, K. Hadi¹, P. Randhawa¹, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…