Articles tagged "Antibodies"

2019 American Transplant Congress
Outcomes Of Treatment Of Late Vs Early Acute Antibody-mediated Rejection In Renal Transplant Recipients – A Single Center Experience
R. Prashar, N. Sulejmani, A. Patel
Henry Ford Transplant Institute, Detroit, MI
*Purpose: The diagnostic accuracy and treatment options for acute antibody-mediated rejection (aABMR) in RTRs has improved over the last several years. However,response to treatment in…
2019 American Transplant Congress
CyTOF and RNAseq Analyses Unravel Early Phenotypic and Transcriptional Changes in Antibody-Secreting and Memory B Cells >1 Year Prior to Antibody-Mediated Rejection
C. Fischman¹, M. Fribourg¹, J. Ansari², L. Gallon², F. Ginevri³, P. Comoli⁴, M. Cioni³, A. Nocera³, M. Bruschi³, C. Cantarelli¹, L. Perin⁵, P. Cravedi¹
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Medicine, Northwestern University, Chicago, IL, ³Department of Medicine, IRCCS Istituto G. Gaslini, Genoa, Italy, ⁴Department of Medicine, IRCCS San Matteo Hospital, Pavia, Italy, ⁵Department of Urology, Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: While the negative impact of anti-HLA donor specific antibodies (DSA) on graft outcomes has been extensively investigated, little is known about early changes in…
2019 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation
F. Messner¹, Y. Guo¹, R. Chen², Y. Kuo², G. Brandacher¹, B. Oh¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD, ²Division of Plastic Surgery, Kaohsiung Medical Univerity Hospital, Kaohsiung, Taiwan
*Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…
2019 American Transplant Congress
Intra-Operative Kinetics of Anti-HLA Antibodies in Simultaneous Liver-Kidney Transplantation
M. Kueht, P. Jindra, M. Cusick, N. Galvan, A. Rana, J. Goss
Baylor College of Medicine, Houston, TX
*Purpose: In simultaneous liver-kidney transplantation (SLKT) in highly-sensitized patients, donor specific anti-HLA antibodies (DSA) can be present prior to transplant leading to positive crossmatch, yet…
2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
K. Venkatachalam, R. Delos Santos, B. Heady, A. Malone, T. Alhamad
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…
2019 American Transplant Congress
Utilizing Ides To Eliminate Residual Antibodies Targeting Xenografts
C. Rickert, K. Lee, N. Tanimine, J. Lei, A. Cuenca, N. Feeney, K. Deng, H. Yeh, J. F. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: A significant hinderance to the successful use of xenotransplantation has been the presence of preformed antibodies against the donor antigens, known as xenoantigens. Using…
2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹
¹Pathology, Michigan Medicine, Ann Arbor, MI, ²Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
2019 American Transplant Congress
Resistance of T Follicular Helper Cells to Depletion by Anti-Thymocyte Globulin
M. Pérez-Sáez¹, N. Murakami², T. J. Borges², P. T. Sage², J. Pascual¹, L. V. Riella²
¹Nephrology, Hospital del Mar, Barcelona, Spain, ²Brigham and Women´s Hospital, Harvard Medical School, Boston, MA
*Purpose: T follicular helper (Tfh) cells are a subset of CD4+ T cells that specializes in providing help for germinal center (GC) reactions where B…
2019 American Transplant Congress
Peritubular Capillary C4d Positivity in Renal Allograft Biopsies: Implications for Allograft Survival
A. Bailey, S. Tremblay, A. R. Shields, J. Wang, R. Alloway, E. S. Woodle
Transplant Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: C4d deposition in the peritubular capillaries (PTCs) is associated with acute antibody mediated rejection (AMR) and reduced renal allograft survival. PTC C4d positivity, however,…
2019 American Transplant Congress
Clazakizumab as an Agent to Reduce Donor Specific HLA Antibodies and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation
S. C. Jordan¹, N. Ammerman¹, M. Toyoda², E. Huang¹, C. C. Nast³, A. Peng¹, S. Sethi¹, R. Najjar¹, I. Kim¹, K. Lim¹, J. Choi¹, A. Vo¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Lab, Cedars-Sinai Medical Ctr, Los Angeles, CA, ³Department of Pathology, Cedars-Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…