Articles tagged "Antibodies"

2020 American Transplant Congress
Possible Mechanism of Sensitization against Angiotensin Type II Receptor after LVAD Implantation
P. Kimball¹, V. Chau², F. McDougan¹, M. Flattery², K. Shah²
¹Surgery, VCUHS, Richmond, VA, ²Cardiology, VCUHS, Richmond, VA
*Purpose: Detection of antibody (Ab) against angiotensin-II receptor (AT1R) following VAD implantation portends poorer outcomes for heart transplantation (HT). However, the cause of this sensitization…
2020 American Transplant Congress
BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial
S. Tremblay¹, A. Rike-Shields², A. Govil¹, M. Cardi³, P. Brailey¹, R. Alloway¹, E. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²Surgery, U Cincinnati, Christ Hospital, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH
*Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…
2020 American Transplant Congress
HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies
J. Lauronen¹, T. Jaatinen¹, J. Holgersson², C. Naper³, J. Peräsaari¹
¹Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, ²Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, ³Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway
*Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
2020 American Transplant Congress
Post-Transplant Rebound and Not Baseline Anti-A Titers are Associated with Acute Antibody-Mediated Rejection in A₂– to B/O Incompatible Kidney Transplantation
V. Kumar, D. Mompoint-Williams, M. Marques, P. MacLennan, M. Mustian, J. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Decreased antigen expression among blood group A subtype 2 (A2) donor kidneys allows these organs to be considered as universal donors; under the new…
2020 American Transplant Congress
Passenger Lymphocyte Syndrome Due to Anti-Rh(D) Reactivity after Kidney Transplantation: A Case Report
S. Nemr¹, S. Bani Hani¹, E. Klohe², C. Gresens³, S. Desmond¹, O. Ojogho¹
¹Kidney and Pancreas Transplant Program, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, WA, ²HLA Laboratory, Inland Northwest Blood Center, Spokane, WA, ³Inland Northwest Blood Center, Spokane, WA
*Purpose: PLS can occur soon after solid organ transplantation when donor-derived antibodies against recipient red cell antigens are produced and lead to hemolysis. The anemia…
2019 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Improve Risk Stratification for Kidney Allograft Outcomes at the Time of Transplantation
C. Lefaucheur¹, D. Viglietti¹, Y. Bouatou¹, A. Philippe², D. Pievani¹, O. Aubert¹, D. Glotz¹, C. Legendre¹, A. Loupy¹, D. Dragun²
¹Paris Translational Research Center for Organ Transplantation, Paris, France, ²Medical Faculty of the Charité Berlin, Berlin, Germany
*Purpose: Current state-of-the-art pre-transplant risk stratification relies on the HLA system. Non-HLA agonistic angiotensin II type 1 receptor antibodies (AT1R-Ab) have been associated with allograft…
2019 American Transplant Congress
CD19⁺Tim-1⁺ Regulatory B Cells Mediate the Balance of Th17 Treg to Decrease the Level of Donor-Specific Antibodies in Mice Secondary Skin Transplantation Model
Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: In this study, we were aimed to explore the potential influence of CD19+Tim-1+ Regulatory B cells (Bregs) on the production of DSAs in a…
2019 American Transplant Congress
High HLA-DQ Epitope Mismatch Load and Low Tacrolimus Level Are Associated with Development of De Novo Donor Specific Antibody
D. Lee¹, B. Kim², J. Kim³, I. Kim⁴, M. Jeon⁵, J. Ahn¹, S. Choi⁶
¹Nephrology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ²Laboratory Medicine, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ³Surgery, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁴Urology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁵Pathology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁶Transplantation Center, Coordinator : Nurse, Maryknoll Medical Center, Busan 48972, Korea, Republic of
*Purpose: Purpose of our study is to evaluate the clinical significance of HLA class II epitope mismatch loads for the development of de novo DSA…
2019 American Transplant Congress
Outcomes Of Treatment Of Late Vs Early Acute Antibody-mediated Rejection In Renal Transplant Recipients – A Single Center Experience
R. Prashar, N. Sulejmani, A. Patel
Henry Ford Transplant Institute, Detroit, MI
*Purpose: The diagnostic accuracy and treatment options for acute antibody-mediated rejection (aABMR) in RTRs has improved over the last several years. However,response to treatment in…
2019 American Transplant Congress
CyTOF and RNAseq Analyses Unravel Early Phenotypic and Transcriptional Changes in Antibody-Secreting and Memory B Cells >1 Year Prior to Antibody-Mediated Rejection
C. Fischman¹, M. Fribourg¹, J. Ansari², L. Gallon², F. Ginevri³, P. Comoli⁴, M. Cioni³, A. Nocera³, M. Bruschi³, C. Cantarelli¹, L. Perin⁵, P. Cravedi¹
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ²Department of Medicine, Northwestern University, Chicago, IL, ³Department of Medicine, IRCCS Istituto G. Gaslini, Genoa, Italy, ⁴Department of Medicine, IRCCS San Matteo Hospital, Pavia, Italy, ⁵Department of Urology, Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: While the negative impact of anti-HLA donor specific antibodies (DSA) on graft outcomes has been extensively investigated, little is known about early changes in…