Articles tagged "Antibodies"

2022 American Transplant Congress
Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?
S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…
2022 American Transplant Congress
Polymorphisms in Ctla-4 Predict De Novo Donor Specific Antibody Formation After Kidney Transplantation
K. Ono, K. Ide, H. Yamane, S. Akimoto, N. Tanimine, H. Tahara, M. Ohira, Y. Tanaka, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: The post-transplant development of donor-specific antibodies (DSAs) initiates the antibody-mediated rejection, which is associated with an increased rate of graft loss. Therefore, risk prediction…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
The Role of Donor Sex in Females Undergoing Repeat Kidney Transplant: Does Prior Donor Sex Matter?
S. Craig¹, K. Tennankore², A. J. Vinson²
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Female recipients of male donor kidneys are at increased risk for graft failure compared with all other donor-recipient sex pairings. The presumed mechanism relates…
2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
J. L. Alejo¹, T. Chiang¹, J. Mitchell¹, A. Abedon¹, L. Thomas¹, A. Chang¹, S. Bae¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…
2022 American Transplant Congress
Sars-cov2 Antibody Kinetics and Durability Three and Six Months After Two-Doses of MRNA Vaccination in Liver Transplant Recipients
A. Chang¹, A. T. Strauss¹, T. P. Chiang¹, A. Jennifer¹, H. Nicole¹, L. Zeiser¹, B. Boyarsky¹, R. Avery¹, A. Tobian¹, M. Levan¹, D. Warren¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Wisconsin School of Medicine, Madison, WI
*Purpose: nti-spike antibody response to SARS-CoV-2 vaccination is diminished in LT recipients compared to the general population so understanding durability for those that do respond…
2022 American Transplant Congress
Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice
I. Sayin¹, S. Khiew², D. Yin¹, P. Sage³, C. B. Cavazzoni³, R. King⁴, A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Merck, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Department of Microbiology, University of Alabama, Birmingham, AL
*Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…
2022 American Transplant Congress
NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis², X. Gu¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France
*Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
2022 American Transplant Congress
Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, S. E. Benner¹, O. Akinde¹, Y. Eby¹, K. H. Wang¹, S. Saraf², J. M. Garonzik-Wang³, S. L. Klein¹, J. R. Bailey¹, A. L. Cox¹, J. N. Blankson¹, C. M. Durand¹, D. L. Segev¹, W. A. Werbel¹, A. A. Tobian¹
¹Johns Hopkins University, Baltimore, MD, ²National Institute of Allergy and Infectious Diseases, Bethesda, MD, ³University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
2022 American Transplant Congress
Effect Of A Fourth Covid-19 Vaccine Dose On Omicron Variant Neutralization In Solid Organ Transplant Recipients
A. Karaba, A. Abedon, J. Alejo, C. X. Qin, D. Warren, J. Ruff, T. Aytenfisu, T. S. Johnston, O. Akinde, A. Pekosz, S. Klein, A. Cox, D. Segev, A. Tobian, W. Werbel
Johns Hopkins University, Baltimore, MD
*Purpose: Humoral response to COVID-19 vaccines is attenuated in many solid organ transplant recipients (SOTRs), necessitating additional primary and booster vaccinations. The omicron variant demonstrates…