Articles tagged "Antibodies"

2022 American Transplant Congress
Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients
Y. Yoo¹, J. Husson², T. Iraguha³, S. Niederhaus⁴, X. Wen⁵, A. Crane⁵, A. Carrier⁵, J. Avruch⁵, A. Ahuja⁶, M. Mathew⁷, S. Dahiya⁸, A. P. Rapoport⁸, D. Atanackovic⁸, K. K. Saharia²
¹Inst of Human Virology, Baltimore, MD, ²Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, ³Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, ⁴Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, ⁵Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, ⁶Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, ⁷Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, ⁸Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD
*Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
2022 American Transplant Congress
Incidence of De Novo Donor Specific Antibodies After Early Steroid Withdrawal in Kidney Transplant Recipients
D. Majmundar, S. Karhadkar, A. Diamond, J. Au, C. Ruggia-Check
Temple University Hospital, Philadelphia, PA
*Purpose: Early steroid withdrawal (ESW) regimens may lead to the formation of de novo donor-specific antibodies (dnDSA) post-kidney transplant, which increases the risk of antibody-mediated…
2022 American Transplant Congress
Use of Pronase to Identify HLA Crossmatch Antibody Interference
N. Hendren¹, C. Lacelle¹, S. Carter¹, J. L. Grodin¹, E. Hardin², M. Farr³, S. Garg¹
¹UT Southwestern, Dallas, TX, ²University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern, Dallas, TX
*Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…
2022 American Transplant Congress
The Natural History of De Novo DSA After Kidney Transplantation
C. López del Moral¹, N. Lachmann², S. Hergovits², D. Stauch², A. Akifova³, M. Naik³, B. Osmanodja³, D. Schmidt³, K. Budde³
¹Nephrology department-IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin, Berlin, Germany, ³Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Germany
*Purpose: De novo donor-specific antibodies(dnDSA) are key in the diagnosis of antibody-mediated rejection(ABMR) and are related to graft loss(GL). Luminex® provides semi-quantitative information with the…
2022 American Transplant Congress
Post-Xenotransplant Antibody Specificities Against Swine, Monkey and Human Leukocyte Antigens in Highly Sensitized Nonhuman Primate Model
I. DeLaura, I. Anwar, M. Manook, D. Olaso, J. Yoon, R. Baldi, A. Jackson, S. Knechtle, J. Kwun
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Xenotransplantation has been proposed as a bridge to transplant for allosensitized patients. However, the potential of xenotransplantation to broaden HLA allosensitization due to MHC…
2022 American Transplant Congress
Immunogenicity of a 3rd Dose of Mrna Covid-19 Vaccine in Kidney Transplant Recipients Who Failed to Respond to 2 Prior Doses
W. Werbel¹, A. Karaba¹, T. Chiang¹, T. Liang¹, A. Massie¹, M. Bettinotti¹, W. Clarke¹, N. Watson², A. Tobian¹, C. Durand¹, N. Bridges², D. Rostrosen², C. Larsen³, P. Heeger⁴, D. Segev¹
¹Johns Hopkins, Baltimore, MD, ²NIAID, Bethesda, MD, ³Emory University, Atlanta, GA, ⁴Mt. Sinai School of Medicine, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have diminished immune response and protection after 2-dose mRNA COVID-19 vaccination. It is unknown if additional doses improve neutralization of…
2022 American Transplant Congress
Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies
X. Zhang, S. Wisel, I. Kim, S. Jordan
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
2022 American Transplant Congress
The Role of LAG3 in Antibody Responses to Kidney Transplantation
M. Nicosia¹, R. Fan¹, J. Lee², V. Gorbacheva¹, A. M. Beavers¹, N. Dvorina¹, W. Baldwin III¹, R. L. Fairchild¹, B. Min³, A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Cardiovascular and Metabolic Science, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ³Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…
2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
J. Tang¹, A. Vo¹, E. Huang¹, X. Zhang², N. Ammerman¹, A. Peng¹, R. Najjar¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
2022 American Transplant Congress
Faster B Cell Rebound is Observed Following Xenotransplantation Compared to Allotransplantation in a Highly Sensitized Nonhuman Primate Kidney Transplantation Model
I. DeLaura, M. Manook, D. Olaso, J. Yoon, R. Baldi, S. Knechtle, J. Kwun
Surgery, Duke Transplant Center, Durham, NC
*Purpose: Xenotransplantation outcomes have been greatly improved due to the advent of genetically engineered pigs and agents targeting the CD40-CD40L signaling pathway. However, studies have…