Articles tagged "Antibodies"

2020 American Transplant Congress
Possible Mechanism of Sensitization against Angiotensin Type II Receptor after LVAD Implantation
P. Kimball¹, V. Chau², F. McDougan¹, M. Flattery², K. Shah²
¹Surgery, VCUHS, Richmond, VA, ²Cardiology, VCUHS, Richmond, VA
*Purpose: Detection of antibody (Ab) against angiotensin-II receptor (AT1R) following VAD implantation portends poorer outcomes for heart transplantation (HT). However, the cause of this sensitization…
2020 American Transplant Congress
BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial
S. Tremblay¹, A. Rike-Shields², A. Govil¹, M. Cardi³, P. Brailey¹, R. Alloway¹, E. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²Surgery, U Cincinnati, Christ Hospital, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH
*Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…
2020 American Transplant Congress
HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies
J. Lauronen¹, T. Jaatinen¹, J. Holgersson², C. Naper³, J. Peräsaari¹
¹Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, ²Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, ³Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway
*Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
2020 American Transplant Congress
Post-Transplant Rebound and Not Baseline Anti-A Titers are Associated with Acute Antibody-Mediated Rejection in A₂– to B/O Incompatible Kidney Transplantation
V. Kumar, D. Mompoint-Williams, M. Marques, P. MacLennan, M. Mustian, J. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Decreased antigen expression among blood group A subtype 2 (A2) donor kidneys allows these organs to be considered as universal donors; under the new…
2020 American Transplant Congress
Passenger Lymphocyte Syndrome Due to Anti-Rh(D) Reactivity after Kidney Transplantation: A Case Report
S. Nemr¹, S. Bani Hani¹, E. Klohe², C. Gresens³, S. Desmond¹, O. Ojogho¹
¹Kidney and Pancreas Transplant Program, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, WA, ²HLA Laboratory, Inland Northwest Blood Center, Spokane, WA, ³Inland Northwest Blood Center, Spokane, WA
*Purpose: PLS can occur soon after solid organ transplantation when donor-derived antibodies against recipient red cell antigens are produced and lead to hemolysis. The anemia…
2020 American Transplant Congress
High-Risk Antibodies Pre-Transplant Impacts Outcome after Heart Transplantation
J. A. Kobashigawa, M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, L. Czer, F. Esmailian
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Pre-transplant circulating antibodies (Abs) are known to impact outcome after heart transplantation (HTx). Abs can now be detected by single-bead assay but also characterized…
2020 American Transplant Congress
Navigating Through IgM Antibodies in Deceased Donor Kidney Transplants from A2/A2B Donors to B Recipients
M. Kueht, A. Gamilla-Crudo, S. Hussain, R. Kulkarni, J. Fair, H. Stevenson-Lerner, M. Mujtaba
University of Texas Medical Branch, Galveston, TX
*Purpose: Multiple studies have shown acceptable deceased donor transplant (DDT) outcomes from A2 and A2B donors into B recipients; however, concerns remain for acute rejection…
2020 American Transplant Congress
Clinical Relevance of Immunoglobulin M Deposition in Peritubular Capillaries in ABO-Incompatible Kidney Transplantation
D. Toki¹, M. Okumi², K. Unagami², Y. Kakuta², H. Ishida², K. Yamashita¹, H. Tachibana¹, A. Hayashida¹, T. Horiuchi¹, Y. Ishiyama¹, K. Honda³, T. Kondo¹, K. Tanabe²
¹Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan, ²Urology, Tokyo Women's Medical University, Tokyo, Japan, ³Anatomy, Showa University, Tokyo, Japan
*Purpose: Immunoglobulin M (IgM) deposition in peritubular capillaries (PTCs) is rarely identified in renal allograft biopsies of ABO-compatible kidney transplantation. In ABO-incompatible kidney transplantation (ABOI-KTx)…
2020 American Transplant Congress
Pre-Transplant Detection of Anti-at1r Antibodies and Pediatric Kidney Transplantation Outcomes
K. Hitchman¹, C. Usenko², R. Hinojosa¹, D. Ranch¹
¹UT Health San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1R Ab) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant…
2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…