2020 American Transplant Congress
Natural Antibodies and Left Ventricular Assist Device Complications
*Purpose: Left ventricular assist device (LVAD) implantation is followed by a sharp increase in serum levels of IgG natural antibodies (Nabs) recognizing oxidation-specific epitopes (OSE)…2020 American Transplant Congress
Multiplicity of Non-HLA Targets for Antibodies Developed in Association with Ventricular Assist Device Implantation
Baylor University Medical Center and Baylor Scott & White Research Institute, Dallas, TX
*Purpose: Multiple non-HLA antibodies have been implicated in poor outcomes after heart transplantation. Development of HLA and Non-HLA antibodies have been reported in association with…2020 American Transplant Congress
Next Generation Sequencing B Cell Receptor Reveals B Cell Clones Encoding HLA Antibody in Transplant Recipients
HLA and Immunogenetcis Laboratory /CTC, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: The development of HLA donor specific antibodies (DSA) increases the risk of antibody mediated rejection and is an independent predictor of poor patient survival.…2020 American Transplant Congress
Anticipated Observations: The Role of DQ Antigen Frequencies among Donors and Recipients in a Pediatric Renal Transplant Cohort
*Purpose: Donor specific HLA antibodies (DSA) that develop in the face of donor-recipient HLA mismatches are well-established independent predictors of graft loss in solid organ…2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…2020 American Transplant Congress
Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection
Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2020 American Transplant Congress
Possible Mechanism of Sensitization against Angiotensin Type II Receptor after LVAD Implantation
1Surgery, VCUHS, Richmond, VA, 2Cardiology, VCUHS, Richmond, VA
*Purpose: Detection of antibody (Ab) against angiotensin-II receptor (AT1R) following VAD implantation portends poorer outcomes for heart transplantation (HT). However, the cause of this sensitization…2020 American Transplant Congress
BAFF Inhibition to Prevent Antibody Rebound Following Proteasome Inhibitor-Based Desensitization: A Randomized, Controlled Trial
*Purpose: Proteasome inhibitor (PI) therapy reduces bone marrow plasma cells and HLA antibodies (Abs) in renal transplant candidates. However, rebound is common in many patients…2020 American Transplant Congress
HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies
*Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…2020 American Transplant Congress
Post-Transplant Rebound and Not Baseline Anti-A Titers are Associated with Acute Antibody-Mediated Rejection in A2– to B/O Incompatible Kidney Transplantation
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Decreased antigen expression among blood group A subtype 2 (A2) donor kidneys allows these organs to be considered as universal donors; under the new…
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