Articles tagged "Antibodies"

2021 American Transplant Congress
The Summarized Assessment of Endothelin a Receptors Expression in Renal Transplant Compartments is Associated with Antibody Mediated Rejection
M. Banasik¹, K. Nowanska¹, P. Donizy², K. Koscielska-Kasprzak³, S. Zmonarski¹, M. Kuriata-Kordek¹, A. Tukiendorf⁴, A. Hałoń², D. Janczak⁵, M. Krajewska¹
¹Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland, ²Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Wroclaw, Poland, ³Research laboratory, Wroclaw Medical University, Wroclaw Medical University, Wroclaw, Poland, ⁴Department of Public Health, Wroclaw Medical University, Wroclaw, Poland, ⁵Department of General, Vascular and Transplant Surgery, Wroclaw Medical University, Wroclaw, Poland
*Purpose: The presence of non-HLA anti-endothelin A receptor antibodies may be important in transplant injury but the expression of the endothelin A receptor (ETA receptor)…
2020 American Transplant Congress
The Banff Classification of Antibody-Mediated Rejection in Kidney Allografts: Comparison of Predictive Performance for Allograft Failure in Previous and Current Editions
J. Callemeyn¹, H. Ameye¹, M. Coemans¹, A. Senev², E. Lerut³, B. Sprangers¹, D. Kuypers¹, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium
*Purpose: Since its introduction in 2001, the Banff classification for antibody-mediated rejection (ABMR) has undergone significant changes, mainly by inclusion of C4d-negative ABMR in 2013…
2020 American Transplant Congress
Safety and Immunogenicity of Adjuvanted Recombinant Subunit Herpes Zoster Vaccine in Lung Transplant Recipients
C. Hirzel¹, V. H. Ferreira¹, A. G. L’Huillier¹, T. Ku¹, M. Ierullo¹, C. Miao², D. S. Schmid², J. Tikkanen¹, L. G. Singer¹, A. Humar¹, D. Kumar¹
¹University Health Network, Toronto, ON, Canada, ²CDC, Atlanta, GA
*Purpose: The new adjuvanted subunit recombinant herpes zoster vaccine (RZV; Shingrix™) may have potential utility in transplant patients for the prevention of shingles, but there…
2020 American Transplant Congress
Preoperative Antibody Titer Against BK Polyomavirus May Predict BK Polyomavirus-Associated Nephropathy after Kidney Transplantation
M. Saito, S. Satoh, K. Numakura, R. Sagehashi, R. Yamamoto, A. Koizumi, T. Nara, S. Narita, T. Habuchi
Urology, Akita University Hospital, Akita, Japan
*Purpose: BK polyomavirus (BKPyV) is a causative agent of BKPyV-associated nephropathy (BKPyV-AN) and hemorrhagic cystitis, which occurs subsequent to BKPyV reactivation. Intravenous immunoglobulin is presumed…
2020 American Transplant Congress
The Role of Complement-Split Products as Biomarkers for Acute Antibody-Mediated Rejection of Kidney Allografts
B. G. Abu Jawdeh¹, B. Campos-Naciff¹, K. Harrison¹, K. Meganathan¹, A. Kumar², M. Anand¹, A. Govil¹, E. S. Woodle¹, B. P. Dixon³
¹University of Cincinnati, Cincinnati, OH, ²All India Institute of Medical Sciences, New Delhi, India, ³University of Colorado, Aurora, CO
*Purpose: Acute antibody-mediated rejection (AMR) is mediated by the activation of the classical complement system in addition to non-complement dependent inflammatory pathways. Complement fixation by…
2020 American Transplant Congress
Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice
B. Anjum, B. Motyka, I. Adam, J. Fersovich, M. Sulzer, J. Pearcey, K. Tao, L. J. West
Dept Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO histo-blood group incompatibility is a barrier in solid organ transplant due to the presence of ‘natural’ preformed ABO antibodies. However, ABO-incompatible (ABOi) heart…
2020 American Transplant Congress
Do the Characteristics of Donor Specific Antibody Truly Predict Severity of Cardiac Allograft Vasculopathy Late after Transplantation?
K. Nishihara, J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, A. Shen, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The development of donor specific antibody (DSA) has been correlated to the development of cardiac allograft vasculopathy (CAV) after heart transplantation. However, it has…
2020 American Transplant Congress
Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production
R. Benedetti Gassen, B. Aoyama, M. Lima, T. Borges, M. Pérez-Sáez, N. Murakami, P. Sage, J. Pascual, L. V. Riella
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…
2020 American Transplant Congress
Impact of Desensitization Strategies with Proteosome Inhibition and Costimulation Blockade on Xenoreactive Humoral Responses
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. P. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacles to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Simultaneously Detection of ddcfDNA in Plasma and Urine Assist to Determine the Type of Rejection in Renal Transplant Patients
D. Cheng¹, F. Liu², H. Liu², T. Jiang², Y. Zhou³, L. Shu², X. Li¹, K. Xie¹, X. Ni¹, J. Chen¹, J. Ge², Z. Liu¹, H. Shi³
¹Jinling Hospital Nanjing University, Nanjing, China, ²AlloDx, Shanghai; Suzhou, China, ³Jiangsu University, Zhenjiang, China
*Purpose: The correct diagnosis and treatment of acute rejection (ABMR and TCMR) are the key to the long-term survival after renal transplantation. Renal biopsy is…