2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…2021 American Transplant Congress
Utility of Donor-Derived Cell Free DNA for Detecting ABMR in Patients With AT1R Antibodies
*Purpose: The presence of angiotensin II type 1 receptor (AT1R) antibodies is associated with non-HLA active antibody mediated rejection (ABMR). The frequent co-existence of negative…2021 American Transplant Congress
Longitudinal Antibody Response and Viral Loads in Covid-infected Organ Transplant Recipients
*Purpose: The full spectrum of COVID-19 disease and the impact of disease severity on antibody response and viral shedding dynamics in transplant patients is unclear.…2021 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…2021 American Transplant Congress
Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti – HLA Antibodies After Kidney Transplantation
Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: The aim of this study was to investigate graft outcomes based on the presence of donor-specific anti-HLA antibodies (DSA) and the time of diagnosis…2021 American Transplant Congress
COVID-19 in the Kidney Transplant Waitlist Population
1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA
*Purpose: Through banked serum samples from transplant candidates across Georgia, we characterize the prevalence, timing, and duration of SARS-CoV-2 seropositivity and investigate the impact on…2021 American Transplant Congress
Targeting Il-21 Receptor Shifts Tfh/tfr Balance and Ameliorateschronic Antibody Mediated Rejection
Tianjin First Central Hospital, Tianjin, China
*Purpose: Donor specific antibody (DSA) plays a central role in chronic kidney allograft injury. As a trigger of humoral alloimmune response, follicular T helper cells(Tfh)…2021 American Transplant Congress
The Clinical Significance of Preformed C1q-binding Donor-specific HLA Antibodies in Kidney Transplantation
*Purpose: Complement activation is one dominant mechanism which cause allograft injury in kidney transplantation (KT). Anti-HLA donor-specific antibodies (DSA) that bind to HLA molecules on…2021 American Transplant Congress
SARS-CoV-2 Antibody Response After Induction Therapy in Kidney Transplant Recipients
*Purpose: SARS-CoV-2 antibody prevalence in kidney transplant recipients is beginning to be reported, although little is known about the humoral immune response in the immediate…2021 American Transplant Congress
Anti-CD272 Antibody (6B2) Generated Foxp3+Regulatory T Cells and Suppressed Donor Specific Antibody in Murine Cardiac Transplant Model
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
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