2015 American Transplant Congress
Calcineurin (CNI) Exposure Reduces the Risk of Post-Transplant DSA After Deceased Donor Kidney Transplantation
General Surgery, The Ohio State University, Columbus, OH.
We use ATG induction with immediate rapamune (Rapa) and delayed CNI immunosuppression following kidney transplantation. Mycophenolic acid (MPA) is substituted for CNI to avoid renal…2015 American Transplant Congress
Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury
The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…2015 American Transplant Congress
Incidence and Impact of De Novo Donor-Specific Anti-HLA Antibodies in ABO-Compatible Liver-Transplant Recipients
Background: The incidence and consequences of de novo donor-specific anti-HLA antibodies (DSAs) after liver transplantation (LT) are not well known. Thus, we investigated the incidence,…2015 American Transplant Congress
A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies
HLA antibody (Ab) mediated complement activation on endothelial cells (EC) is likely a critical driver of antibody-mediated inflammation. Production of complement anaphylatoxins by HLA antibodies…2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…2015 American Transplant Congress
Reasons for Match Offer Refusals and Efforts to Reduce Them in the OPTN/UNOS Kidney Paired Donation Pilot Program (KPDPP)
1UNOS, Richmond, VA; 2Carnegie Mellon Univ, Pittsburgh, PA; 3Univ Hosp Case Med Ctr, Cleveland, OH.
Background: The OPTN/UNOS KPDPP has been finding 2-way, 3-way, and chain exchanges since Oct 2010. Though the number of pairs entered, matches found, and transplants…2015 American Transplant Congress
Early Vs. Late Acute Antibody Mediated Rejection Among Renal Transplant Recipients in Terms of Its Response to Rituximab Therapy-Single Center Expereince
Nephrology, OTC of Kuwait, kuwait, Kuwait.
IntroductionThere are no comparable trials concerning the use of rituximab among renal transplant recipients with acute antibody mediated rejection.Aim of the study:We aimed to compare…2015 American Transplant Congress
Impact of Positive Crossmatch Due to Non-HLA Antibodies on Graft Outcomes in Renal Transplantation
Houston Methodist Hospital, Houston, TX.
It is widely recognized that a positive allogeneic crossmatch (+alloXM) due to pre-existing human leukocyte antigen (HLA) antibodies is associated with early rejection episodes. However,…2015 American Transplant Congress
Alloantibody-Dependent Macrophage-Mediated Hepatocellular Damage Is Dependent on FcγRI, FcγRIII, and Reactive Oxygen Species
Dept of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
Alloantibodies (alloAb) play a critical role in rejection after transplantation. Despite this, the cellular mechanisms contributing to alloAb-mediated allograft damage are not well understood. Using…
American Transplant Congress abstracts