2015 American Transplant Congress
Pre-Transplant Levels of TFH cell-Inducing Pro-Inflammatory Cytokines Correlate With DSA Formation After Kidney Transplantation
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…2015 American Transplant Congress
Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation
[Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…2015 American Transplant Congress
In Vitro Evidence That CTLA4Ig Attenuates Recall Alloantibody Responses
Background: CTLA4Ig is an agonist that blocks CD28-B7 costimulation, downregulating T cell immunity, but also appears to negate T cell-dependent B cell activation, thus inhibiting…2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…2015 American Transplant Congress
Endosome-Based Activation of Non-Canonical NF-kB Signaling By Membrane Attack Complexes
Using sera from transplant patients with high-titer panel reactive antibody (PRA), we previously described a model for studying the effects of alloantibody binding and complement…2015 American Transplant Congress
CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant
Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…2015 American Transplant Congress
Immunological Characterization of Full Facial Transplant Recipients
Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…2015 American Transplant Congress
Does the C1q Assay Predict the Result of Lymphocyte Flow Cross-Match (FCxM) in Potential Renal Transplant Recipients With HLA-DSA and AHG-CDC CxM negative?
Background. The presence of pre-transplant HLA donor specific antibodies (DSA) is a recognized risk factor for acute rejection. However, due to the test's (LUMINEX) high…2015 American Transplant Congress
Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Follicular T helper (Tfh) cells play a critical role in follicular B cell activation and maturation during antibody responses to allograft. Here we report…2015 American Transplant Congress
Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition
Department of Surgery, CTC, The Ohio State University, Columbus, OH.
mTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressives commonly used to suppress rejection of transplants. Despite widespread use following transplantation…
American Transplant Congress abstracts