Articles tagged "Alloantibodies"

2017 American Transplant Congress
Assessment of Cardiosphere-Derived Cell Exosomes as Possible Modulator of Alloimmunity in a Mouse Model of HLA-A2 Allosensitization.
I. Kim,¹ G. Wu,¹ N.-N. Chai,¹ G. De Couto,² E. Marban,² A. Klein,¹ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: Mounting data indicate that exosomes, a nanosized membrane particle secreted by cells has immune regulatory properties, including anti-inflammation and mediating autocrine, paracrine, and endocrine…
2017 American Transplant Congress
Development of an Anti-HLA Antibody-Producing Humanized Mouse Model.
S. Yanagawa, H. Tahara, H. Ohdan.
Hiroshima University, Hiroshima, Japan; Hiroshima University, Hiroshima, Japan; Hiroshima University, Hiroshima, Japan
Chronic antibody-mediated rejection due to anti-human leukocyte antigen (HLA) antibodies (Abs) is an important problem in organ transplantation. The spleen has been reported to be…
2017 American Transplant Congress
Graft Survival in De Novo Donor-Specific Antibodies and Positive Flow Crossmatch Kidney Transplants Is influenced by Class I and Class II.
S. Montag,^1,2 B. Ho,¹ H. Bhagat,³ E. Lee,^3,4 K. Atiemo,¹ A. Daud,¹ R. Kang,¹ L. Zhao,^1,2 J. Schwartz,³ D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Dept of Preventive Medicine, Northwestern University, Chicago; ³Astellas Pharma Global Development, Northbrook; ⁴Now with UCB, Atlanta
Patients with de novo donor-specific antibodies (dnDSA) show inferior graft survival in numerous small studies. We assessed the effect of dnDSA on graft and patient…
2017 American Transplant Congress
Generation of Natural Antibodies Post Transplant and Association with Kidney Allograft Loss.
S. See,¹ A. Loupy,² O. Aubert,² Y. Veras,¹ X. Lebreton,² B. Gao,³ C. Legendre,² D. Anglicheau,² E. Zorn.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²Department of Kidney Transplantation, Hopital Necker, Université Paris, René Descartes and APHP, Paris, France; ³The First Hospital of Jilin University, Changchun, China
The development of donor specific antibodies (DSA) reacting to mismatched donor class I and class II HLA is a prominent risk factor for kidney graft…
2017 American Transplant Congress
Prospective Monitoring of De Novo Donor-Specific Antibodies: Incidence, Clinical Outcomes and Dynamic Changes Over 5 Years After Kidney Transplantation.
M. Ajaimy, A. Colovai, N. Hayde, J. Graham, M. Lubetzky, L. Kamal, G. De Bocardo, E. Akalin.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx
Background: We aimed to investigate the incidence and dynamic changes of de novo donor-specific-antibodies (dnDSA) after kidney transplantation and clinical outcomes.Methods: This is a prospective…
2017 American Transplant Congress
Prevention of Donor Specific Antibody Production After Skin Allografting by Mobilization of Endogenous Stem Cells Using a Combination of AMD3100 and Low-Dose FK506 in Rats.
A. Ahmadi,¹ L. Qi,¹ R. Wesson,¹ F. Dor,² J. Burdik,¹ B. Philosophe,¹ G. Williams,¹ A. Cameron,¹ Z. Sun.¹
¹Dept. of Surgery, Johns Hopkins University, Baltimore, MD; ²Dept. of Surgery, Imperial College Healthcare, London, United Kingdom
Background: We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in small and large animals…
2017 American Transplant Congress
Incidence of De Novo Donor-Specific Antibodies Following Kidney Transplantation.
B. Ho,¹ H. Bhagat,² E. Lee,^2,3 K. Atiemo,¹ A. Daud,¹ R. Kang,¹ S. Montag,^1,4 L. Zhao,^1,4 J. Schwartz,² D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Astellas Pharma Global Development, Northbrook; ³Now with UCB, Atlanta; ⁴Dept of Preventive Medicine, Northwestern University, Chicago
With a range of frequencies reported in several small studies, true incidence of de novo donor-specific human leukocyte antigen (HLA) antibodies (dnDSA) is unknown. As…
2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
M. Cascalho,¹ E. Farkash,² L. Adam,¹ M. Samaniego,³ J. Platt.
¹Surgery, University of Michigan, Ann Arbor; ²Pathology, University of Michigan, Ann Arbor; ³Internal Medicine, University of Michigan, Ann Arbor
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…
2017 American Transplant Congress
Retrospective Analysis of Kidney Transplant Recipients with Antibody-Mediated Rejection.
G. Piñeiro,¹ E. Desousa,¹ J. Villarreal,¹ M. Lozano,² J. Cid,² M. Sole,³ F. Oppenheimer,¹ F. Diekmann.¹
¹Nephrology and Renal Transplant, Hospital Clinic de Barcelona, Barcelona, Spain; ²Apheresis Unit, Department of Hemotherapy and Hemostasis, Hospital Clinic de Barcelona, Barcelona, Spain; ³Pathology, Hospital Clinic de Barcelona, Barcelona, Spain
Acute antibody mediated rejection (AMR) is a major cause of allograft loss.We retrospectively reviewed all kidney allograft recipients between 2002 and March 2016. Investigated the…
2017 American Transplant Congress
Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.
R. Danger,¹ A. Chenouard,¹ M. Chesneau,¹ S. Castagnet,² P. Guérif,¹ N. Degauque,¹ M. Giral,¹ S. Brouard.¹
¹Inserm UMR 1064, Nantes University Hospital, Nantes, France; ²HLA Laboratory, Etablissement Français du Sang, Nantes, France
Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute…