Articles tagged "Alloantibodies"

2019 American Transplant Congress
Development of De Novo DSA after Kidney Transplant Correlates with Low Quantity of Peripheral Blood “Antibody-Suppressor” CD8⁺T Cells
J. Zimmerer¹, M. Basinger¹, B. Ringwald¹, R. Pelletier¹, A. Rajab¹, A. El-Hinnawi¹, M. Abdel-Rousoul², H. Parekh³, K. Washburn¹, G. Bumgardner¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Clinical Histocompatibility Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: It is well known that CD4+ T cells provide “help” for antibody production in vivo. Our group discovered a novel subset of murine antibody-suppressor…
2019 American Transplant Congress
α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.
J. Yoon, B. Ezekian, M. Manook, J. Kwun, S. Knechtle
Duke Transplant Center, Durham, NC
*Purpose: Previously, we observed that sera from rhesus macaques contained preformed antibodies against wild type (WT) swine splenocytes. In the context of xenotransplantation, preformed xenoantibodies…
2019 American Transplant Congress
Upregulation of Endothelial HLA Class II as a Marker of Antibody Mediated Rejection in Heart Allograft Biopsies
Q. Cai, Y. Butt, A. Hendricks, J. Torrealba
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: In 2013, the ISHLT (International Society of Heart and Lung Transplant) introduced the working classification for pathological changes associated with antibody-mediated rejection of the…
2019 American Transplant Congress
Iguratimod Attenuates the Production of Donor Specific Antibody by Inducing CD19⁺Tim-1⁺ Regulatory B Cells and Imbalance of Th17 Treg
Z. Wang, S. Fei, H. Chen, Z. Han, L. Sun, J. Tao, X. Ju, M. Zheng, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: This study was designed to investigate the effect and mechanisms of Iguratimod on circulating DSA and allograft survival in a skin transplant model.*Methods: Mice…
2019 American Transplant Congress
ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
2019 American Transplant Congress
The Effects of Anti-BAFF Monoclonal Antibody in the HLA-A2 Sensitized Mouse Model
J. Min¹, H. Lee², B. Kim³, K. Park⁴, K. Doh³, T. Kim⁵, H. Yoon⁶, C. Yang⁷, E. Oh², B. Chung⁷
¹Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-si, Korea, Republic of, ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁴Department of Molecular & Cell Biology, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁵Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁶Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea, Republic of, ⁷Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: B-cell activating factor (BAFF) is a cytokine that plays a role in the survival, proliferation and differentiation of B-cells. The aim of this study…
2019 American Transplant Congress
B Cell Immunophenotypes in Transplantation
M. Cascalho¹, M. de Mattos-Barbosa², E. A. Farkash³, J. L. Platt²
¹University of Michigan, Ann Arbor, MI, ²Surgery, University of Michigan, Ann Arbor, MI, ³Pathology, University of Michigan, Ann Arbor, MI
*Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
2019 American Transplant Congress
Subclinical Antibody Mediation Rejection in Stable Kidney Recipients with De Novo Donor Specific Antibodies and Correlation with Donor Derived Cell Free DNA Testing
A. P. Bregman, E. J. Stites, J. Gralla, A. Wiseman, J. E. Cooper
Kidney and Pancreas Transplant, University of Colorado-Denver, Aurora, CO
*Purpose: Subclinical antibody mediated rejection (sAMR) is associated with inferior graft outcomes but its diagnosis relies on the presence of biomarkers as well as histology.…
2019 American Transplant Congress
Iguratimod Inhibits the Donor Specific Antibodies Production and Attenuates the Antibody Mediated Rejection in Rat Kidney Transplantation
Z. Wang, M. Zheng, H. Chen, S. Li, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was designed to investigate the efficacy and related mechanisms of Iguratimod (T-614) in the inhibition of DSAs following kidney transplantation.*Methods: A rat…
2019 American Transplant Congress
Increasing Expression of B-cell Maturation Antigen during the Development of Recall Antibody Responses: A Prospective Pharmaceutical Target for B-cell Suppression?
G. Wu, I. Kim, N. Chai, A. Klein, S. Jordan
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Our previous study found that B cell maturation antigen (BCMA) is increasingly expressed by B/plasma cells during the development of de novo alloantibody responses.…