2018 American Transplant Congress
A Theoretical Framework to Explain Factors That Impact Completion of the Medical Evaluation Process for African American (AA) End-Stage Renal Disease (ESRD) Patient
Black/African Americans (B/AA) are less likely to seek kidney transplantation or complete the pre-transplant medical evaluation despite higher prevalence rates of end-stage renal disease (ESRD).…2018 American Transplant Congress
Investigation of Lower Treatment Failure Rate Seen among Black Kidney Recipients on LCP-Tacrolimus vs. IR-Tacrolimus: Subgroup Analyses of Two Phase 3 Trials
Black kidney transplant recipients are recognized as high risk for inferior allograft survival due to immunologic and non-immunologic factors. Pooled data from 2 Phase 3…2018 American Transplant Congress
Is BMI > 35 a Barrier to Kidney Transplantation?
Organ Transplant, University of Illinois, Chicago, IL.
Background:Although lower rates of patient and graft survival are reported for kidney transplant recipients with BMI > 35, kidney transplant in this group provides a…2018 American Transplant Congress
The Impact of Early versus Late Clinical Outcomes on Disparities in African-American Kidney Transplant Recipients
Background: It is important to better understand the impact of early and late clinical events on disparities in African-American (AA) kidney transplant (KTX), which will…2018 American Transplant Congress
Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs
Purpose: Tacrolimus (TAC) is a substrate for CYP3A4/5 enzymes. It is well-known that variants in these genes are associated with variability in TAC trough concentrations.…2018 American Transplant Congress
Non-Medical Factors Predict Receipt and Type of Kidney Transplant in Veterans
VA Kidney Transplant Centers: IA, OR, PA, TN, Iowa City, Portland, Pittsburgh, Nashville.
Background: African Americans, Hispanic Americans and other minorities have a higher incidence of end-stage kidney disease but lower rates of both deceased and living donor…2018 American Transplant Congress
Does One Size Fit All? Implementing a Protocolized Ambulatory Tacrolimus Dosing Strategy in a Predominantly African American Renal Transplant Population
Medical University of South Carolina, Charleston, SC.
Introduction: African American (AA) KTx recipients have significant tacrolimus (FK) inter patient variability making protocolized dosage adjustment challenging. We sought to evaluate the efficacy &…2018 American Transplant Congress
Prevalence and Impact of CYP3A5 Genomic Variances on Clinical Outcomes among African-American Kidney Transplant Recipients
1Vidant Medical Center, Greenville, NC; 2East Carolina University, Greenville, NC.
Introduction: Kidney transplantation in African American (AA) recipients continues to demonstrate inferior outcomes when compared with other race/ethnicities. Contributing factors encompass differences in pharmacogenomics, and…2018 American Transplant Congress
Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations in Renal Transplant Recipients
University of Illinois Hospital & Health Sciences System, Chicago, IL.
Purpose: To compare three formulations of tacrolimus (TAC) and assess differences in time within therapeutic range (TTR) and variability in levels.Methods: Renal transplant recipients from…2018 American Transplant Congress
Kidney Transplantation in ESKD Patients with a History of Sickle Cell Disease/Trait
Introduction:Kidney transplantation in Sickle Cell Disease patients is fraught with complications, including increased risk of infection and thrombosis. We present long term outcomes of patients…
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