2022 American Transplant Congress » Xenotransplantation

3:30pm-3:40pm

CD14⁺ Monocytes Play a Critical Role in Initiating Xeno-Recognition, Costimulation and Immune-Responses to Porcine Endothelial Cells

H. Xu, A. Kirk, H. Xu

3:40pm-3:50pm

Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys

T. Hirose¹, G. Lassiter¹, D. Ma¹, A. D'Attilio¹, I. Rosales¹, D. Cloonan¹, R. Matheson¹, R. Colvin¹, W. Qin², Y. Kan², J. Layer², R. Anand², V. Paragas², L. Queroz², X. Tan², I. Kohnle², K. Stiede², K. Hall², M. Youd², M. Curtis², J. Markmann¹, T. Kawai¹

3:50pm-4:00pm

The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation

C. Hansen-Estruch¹, M. H. Bikhet¹, M. Javed¹, D. Ayares², A. Katsurada³, R. Satou³, W. Shao³, D. K. Cooper¹, L. G. Navar³, E. Judd⁴

4:00pm-4:10pm

Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes

M. Manook¹, D. Olaso¹, I. Anwar¹, J. Yoon¹, M. Song¹, A. B. Farris², K. Stiede³, K. Hall³, M. Youd³, S. Knechtle¹, J. Kwun¹

4:10pm-4:20pm

First Report of Xenotransplantation from a Pig to Human Recipient

J. Stern¹, V. Tatapudi¹, B. Lonze¹, Z. Stewart¹, M. Mangiola¹, M. Wu¹, S. Mehta¹, E. Weldon¹, R. Dieter¹, N. Lawson¹, A. Griesemer², B. Parent¹, G. Piper¹, P. Sommer¹, S. Cawthon¹, B. Sullivan¹, N. Ali¹, R. A. Montgomery¹

4:20pm-4:30pm

Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient

M. Mangiola, V. Tatapudi, J. Stern, Z. Stewart Lewis, B. Lonze, N. Ali, R. Montgomery

4:30pm-4:40pm

First-in-Human Clinical-Grade Porcine Kidney Xenotransplant

J. E. Locke¹, B. Orandi¹, V. Kumar¹, J. Houp¹, D. Anderson¹, V. Hauptfeld¹, D. Martin², C. Killian¹, S. Macedon¹, N. Budd¹, K. Stegner¹, A. Dandro³, M. Kokkinaki³, K. Kuravi³, R. Reed⁴, H. Fatima¹, G. Baker¹, J. Perry¹, E. Bryant¹, M. Cheung¹, E. Erman¹, K. Kraebber¹, T. Gamblin¹, L. Guy¹, D. Ayares³, P. Porrett¹

4:40pm-4:50pm

Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates

A. K. Singh¹, C. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. Mohiuddin¹

4:50pm-5:00pm

Presence of Infiltrating Regulatory T Cells in the Cardiac Xenografts and Their Potential Role in Graft Survival

A. K. Singh¹, C. E. Goerlich¹, G. Braileanu¹, A. Hershfeld¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, D. Ayares², B. Griffith¹, M. M. Mohiuddin¹