2022 American Transplant Congress » Xenotransplantation

7:00pm-8:00pm

3D Co-Culture System with Porcine Aortic Endothelial Cell Line and Human or Non-Human Primate Cells for Application in the Study of Xeno-Immune Reaction

S. K. Yadav¹, Y. Lee², S. Hurh³, S. Kim², J. Yang⁴, J. C. Jeong²

7:00pm-8:00pm

Cardiomyocyte Cross-Sectional Area Increases After Orthotopic Cardiac Xenotransplantation and is Not Likely a Significant Contributor to Xenograft Growth up to 9 Months

C. E. Goerlich¹, B. Griffith¹, J. Treffalls¹, P. Hanna², S. N. Hong², A. K. Singh¹, D. Ayares³, M. Mohiuddin¹

7:00pm-8:00pm

Clinically Available Immunosuppressive Agents Prolong Pig-to-Primate Kidney Xenograft Survival

I. J. Anwar¹, Q. Gao¹, I. DeLaura¹, J. Yoon¹, R. Baldi¹, M. Youd², K. Stiede², K. Hall², S. Knechtle¹, J. Kwun¹

7:00pm-8:00pm

Faster B Cell Rebound is Observed Following Xenotransplantation Compared to Allotransplantation in a Highly Sensitized Nonhuman Primate Kidney Transplantation Model

I. DeLaura, M. Manook, D. Olaso, J. Yoon, R. Baldi, S. Knechtle, J. Kwun

7:00pm-8:00pm

Implementation of Infectious Disease Surveillance in Recently Deceased Human Xenograft Study

S. J. Cawthon, E. P. Weldon, N. S. Lawson, B. E. Lonze, R. A. Montgomery, S. A. Mehta

7:00pm-8:00pm

Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor

E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer

7:00pm-8:00pm

Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells

R. Matheson¹, B. Gonzalez Nolasco¹, K. Deng¹, R. Garofalo¹, N. Serifis¹, T. M. Coe¹, C. Rhatigan¹, D. Gil¹, D. Cloonan¹, K. Lee¹, K. Hall², M. Youd², J. F. Markmann¹, S. C. Robson³

7:00pm-8:00pm

Post-Xenotransplant Antibody Specificities Against Swine, Monkey and Human Leukocyte Antigens in Highly Sensitized Nonhuman Primate Model

I. DeLaura, I. Anwar, M. Manook, D. Olaso, J. Yoon, R. Baldi, A. Jackson, S. Knechtle, J. Kwun

7:00pm-8:00pm

Pre-Transplantation Liver Immunoadsorption Reduces Liver-Specific Antibody and Complement Deposition without Prolonging Survival in Porcine to Baboon Liver Xenotransplantation

D. J. Cloonan¹, T. Coe¹, N. Serifis¹, R. Matheson¹, S. Maggipinto¹, D. Firl¹, R. Anand², J. Layer², L. Queiroz², K. Stiede², K. Hall², M. Youd², W. Qin², M. Curtis², S. Kimura¹, I. Rosales¹, J. Markmann¹

7:00pm-8:00pm

Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression

M. C. Poznansky

7:00pm-8:00pm

Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

F. Pollok¹, M. R. Connolly¹, A. Calhoun¹, Z. Habibabady¹, S. Miura¹, M. Ma¹, S. Pratts¹, L. Burdorf¹, Y. Kan², J. V. Layer², J. V. Layer², E. Tan², R. Anand², M. Li², K. C. Hall², M. E. Youd², K. Stiede², W. Qin², M. Curtis², A. Azimzadeh¹, R. N. Pierson¹

7:00pm-8:00pm

Triple-Knockout Pig Red Blood Cells as Potential Sources for Blood Transfusion in Alloimmunized Patients with Sickle Cell Disease

T. Yamamoto¹, M. H. Bikhet², H. Q. Nguyen², Y. Cui², M. Javed², S. S. Raza², D. Ayares³, H. Iwase², H. Hara², D. K. Cooper¹