2020 American Transplant Congress » Xenotransplantation

3:15pm-3:27pm

Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival

B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹

3:27pm-3:39pm

Life-Supporting Pig Thymus Plus Kidney Transplantation Leads to Generation of New Baboon T-Cells and Swine-Specific Hyporesponsiveness

Y. Okumura¹, K. Takeuchi¹, Y. Ariyoshi¹, T. Pomposelli¹, L. Boyd¹, D. Alper¹, K. Miyake¹, K. Okubo¹, S. Arn¹, D. Ayares², M. Lorber³, M. Sykes¹, D. Sachs¹, K. Yamada¹

3:39pm-3:51pm

Overcoming Ab-Mediated Xenolung Rejection: Beta4Gal is an Important Pre- and Post-Transplant Ab Target, Relevant to Xenograft Injury in Baboons

L. Burdorf¹, Z. Abady¹, B. Cerel¹, K. Petitpas¹, C. Laird², S. Pratts¹, X. Cheng², C. J. Phelps³, W. Eyestone³, D. L. Ayares³, R. N. Pierson III¹, A. M. Azimzadeh¹

3:51pm-4:03pm

Prolonged Multitransgenic Pig Lung Survival with Attenuated Pulmonary Vascular Resistance Rise During Human Blood Perfusion

M. R. Connolly¹, L. Burdorf¹, S. Pratts¹, B. Cerel¹, Z. Abady¹, W. Quin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², A. Azimzadeh¹, R. N. Pierson III¹

4:03pm-4:15pm

Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation

M. Song, Z. Fitch, K. Samy, Q. Gao, R. P. Davis, F. Leopard, R. Schmitz, N. Huffman, G. Devi, B. Collins, A. D. Kirk

4:15pm-4:27pm

T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen

A. Jagdale¹, H. Iwase¹, H. Nguyen¹, T. Yamamoto¹, D. Ayares², D. Anderson¹, D. Eckhoff¹, D. Cooper¹, H. Hara¹

4:27pm-4:39pm

In-Vivo Application of Ides (Imlifidase) in Nonhuman Primates Results in Xenoreactive Desensitization: A Novel Anti-Humoral Therapy

B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. Robertson³, C. Kjellman³, A. B. Adams¹