2022 American Transplant Congress » Treg/Other Regulatory Cell/Tolerance

7:00pm-8:00pm

A FRET-Based Technique to Quantify Foxp3 Acetylation in T_REG

F. F. Gonzalez¹, G. Vilanova², M. Fribourg¹

7:00pm-8:00pm

A Novel Method for Ex Vivo Stimulation of Mesenchymal Stem Cells via Invariant Natural Killer T Cell Activation with ɑ-galactosylceramide

R. Ishii¹, E. Kawaguchi¹, T. Yamakawa¹, H. Ishigooka¹, T. Ikeda¹, R. Ishiyama¹, K. Saiga¹, T. Takagi¹, Y. Ishii², K. Tanabe¹

7:00pm-8:00pm

A Sustained Injury Response by Regulatory T Cells (Treg) Contributes to Fibrosis to Promote Chronic Rejection After Heart Transplantation

J. Bou Saba¹, L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. Dwyer², E. Colon², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. Turnquist¹

7:00pm-8:00pm

Batf3 and IRF4 in Control of iTreg Differentiation, Stability, and Survival

P. Arnold, X. Xiao, X. Zhang, M. Wen, G. Wang, X. Chu, X. C. Li

7:00pm-8:00pm

Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines

S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam³, B. Schreiber³, A. Wagaa-Gasser¹, A. Chandraker⁴

7:00pm-8:00pm

Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq

N. Sailliet, H. Le Mai, A. Dupuy, C. Fourgeux, M. Chesneau, J. Poschmann, R. Danger, S. Brouard

7:00pm-8:00pm

Characterization of GZMB+ Bregs Transcriptome and Their Impact on Target Cells in Single-Cell RNA-seq

N. Sailliet, H. Le Mai, A. Dupuy, F. Cynthia, M. Chesneau, J. Poschmann, R. Danger, S. Brouard

7:00pm-8:00pm

Deficiency of Antibody-Suppressor CXCR5⁺CD8⁺ T Cells (Not CD4⁺ T_regs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients

J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹

7:00pm-8:00pm

Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts

X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹

7:00pm-8:00pm

Donor-Specificb Cell Dysfunction and Suppressive Ability Are Differentially Induced in Cob-Mediated Transplantation Tolerance

S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹

7:00pm-8:00pm

Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival

R. Steiner¹, A. M. Weijler¹, M. Muckenhuber², J. Sprent³, T. Wekerle⁴, N. Pilat¹

7:00pm-8:00pm

Effector T Cells Potentiate Treg Migration to Allografts

H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand

7:00pm-8:00pm

Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance

W. Burlingham¹, E. Jankowska-Gan², J. Fechner³, C. Little², J. Sullivan⁴, D. Foley¹

7:00pm-8:00pm

Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles

J. S. Rink¹, Y. Sambandam², J. He², J. Mathew³, J. R. Leventhal⁴, C. S. Thaxton⁵

7:00pm-8:00pm

Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts

T. Yokose¹, E. S. Szuter¹, M. T. Guinn¹, J. Ge², I. Rosales³, M. Ford⁴, P. S. Russell¹, A. G. Cuenca², J. C. Madsen¹, R. B. Colvin¹, A. Alessandrini¹

7:00pm-8:00pm

Murine Intrahepatic Regulatory T Cells (TREGS) Modulate Acute Liver Inflammation by Promoting a Protective and Restorative Microenvironment

A. S. Kurt¹, K. Strobl², P. Ruiz¹, A. Sanchez-Fueyo¹, M. Martinez-Llordella¹

7:00pm-8:00pm

Off-the-Shelf Allogeneic Invariant NKT Cells Are Safe in the Dog and Induce Both Killer and Regulatory Immune Cells

A. Rotolo, E. Whelan, M. Atherton, K. Coker, R. Duran-Struuck, N. Mason

7:00pm-8:00pm

Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation

W. J. Burlingham¹, E. Jankowska-Gan², J. Fechner¹, C. Little¹, S. Tripathi³, B. Schreiber³, A. Chandraker³, D. Foley⁴

7:00pm-8:00pm

Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens

C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹

7:00pm-8:00pm

Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes

H. Shin, S. Heo, Y. Kim, N. Lee, Y. Kim, Y. Jung, H. Rim

7:00pm-8:00pm

Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients

C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹

7:00pm-8:00pm

Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease

C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹

7:00pm-8:00pm

Regulatory T and B Cell Responses Are Equally Compromised During Antibody-Mediated Rejection of Kidney Allografts

K. Louis¹, P. Fadakar², C. Macedo², M. Yamada², M. Lucas², X. Gu², A. Zeevi², P. Randhawa², C. Lefaucheur³, D. Metes²

7:00pm-8:00pm

Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft

J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹

7:00pm-8:00pm

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells

A. R. Gupta¹, J. Wang², C. Lareau³, I. Sun², J. Bautista¹, J. Gardner¹

7:00pm-8:00pm

The Role of T Lymphocyte Subsets in Kidney Transplantation

L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²

7:00pm-8:00pm

Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance

S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹

7:00pm-8:00pm

Treg Crosstalk with Both Tumor and Lymphatic Cells Promotes Metastasis Through Lta1b2-ltbr Signaling

W. Piao¹, R. S. Oakes², C. M. Jewell², J. Bromberg¹