2020 American Transplant Congress » Poster Session D: Lymphocyte Biology: Signaling, Co-Stimulation, Regulation

3:30pm-4:00pm

A Novel Immunoresponse Monitoring System to Predict Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients

N. Iwahara¹, K. Hotta¹, D. Iwami¹, Y. Takada¹, H. Higuchi², H. Sasaki², T. Tanabe², N. Shinohara¹

3:30pm-4:00pm

A Single-Cell Transcriptome Atlas of 15 Adult Human Organs

Z. Guo¹, S. He², L. Wang¹, Y. Liu², J. Xu¹, J. Bei², X. He¹

3:30pm-4:00pm

Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

S. Chung, S. Choi

3:30pm-4:00pm

Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells

Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita⁴, M. Niimi¹

3:30pm-4:00pm

Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor

K. Sato, M. Ohira, Y. Imaoka, H. Ohdan

3:30pm-4:00pm

CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel

N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein, T. Brennan

3:30pm-4:00pm

Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus

R. L. Crepeau¹, H. Li¹, H. S. Koehler², M. L. Ford¹, P. D. Winterberg³

3:30pm-4:00pm

DEPTOR Expression within CD4⁺Foxp3⁺ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation

J. Wedel¹, M. Maslyar¹, S. Kong¹, M. Laplante², D. M. Briscoe¹

3:30pm-4:00pm

Dissecting Humoral Alloimmune Sensitization: A Dynamic Interplay of Different Cellular Compartments

A. Torija, A. Favà, E. Crespo, M. Jarque, M. Meneghini, N. Bolaños, J. Grinyo, O. Bestard

3:30pm-4:00pm

Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression

H. Liu, Y. Chen, F. Qiu, Z. Dai

3:30pm-4:00pm

Examination of the TIGIT/CD226 Axis in Kidney Transplant Recipients

G. J. Kavalam, A. D. Desai, A. Chandraker, S. Tripathi

3:30pm-4:00pm

Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation

J. A. Sullivan, J. H. Fechner, E. Jankowska-Gan, W. J. Burlingham, D. B. Kaufman

3:30pm-4:00pm

Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity

L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹

3:30pm-4:00pm

Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration

V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹

3:30pm-4:00pm

Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression

M. Mammadli¹, M. Karimi¹, S. Mahmudlu¹, A. August², W. Huang²

3:30pm-4:00pm

Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation

J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe

3:30pm-4:00pm

Novel Insights Into High Alloantibody Production in CCR5 KO Recipient Mice

J. L. Han¹, J. M. Zimmerer², Q. Zeng³, B. A. Ringwald¹, C. K. Breuer³, G. L. Bumgardner²

3:30pm-4:00pm

PD-1 Signals Murine and Human Treg for Enhanced Migration

W. Piao¹, Y. Xiong¹, L. Li¹, K. Hippen², Y. Zhang², V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar³, L. Riella⁴, J. Bromberg⁵

3:30pm-4:00pm

Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts

M. Nicosia, R. Fan, J. Lee, V. Gorbacheva, A. Beavers, N. Dvorina, W. M. Baldwin III, R. L. Fairchild, B. Min, A. Valujskikh

3:30pm-4:00pm

Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation

L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. K. Dwyer², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. R. Turnquist¹

3:30pm-4:00pm

Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells

H. Cho¹, J. Lee², B. Kwon³, S. Park⁴, H. Park⁴, K. Yoo², K. Park², J. Kim³, S. Kang³

3:30pm-4:00pm

Targeting Th17: TIGIT as a Key Regulator of Tregs/Th17 Cells in Belatacept Resistant Rejection

C. R. Hartigan, M. Wagener, M. L. Ford

3:30pm-4:00pm

The Effect of Undernutrition and Immunosuppression on Cytomegalovirus Specific T Cell Responses

E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹

3:30pm-4:00pm

Treg Use PD-1 for Lymphatic Migration

W. Piao¹, L. Li¹, K. Hippen², Y. Zhang³, Y. Xiong¹, V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar⁴, L. Riella⁵, J. Bromberg⁶

3:30pm-4:00pm

Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation

A. Dangi¹, K. Glinton², M. Sharma¹, S. Yu¹, M. DeBerge², E. B. Thorp², X. Luo¹

3:30pm-4:00pm

Undernutrition and Hypoleptinemia Modulate Cytomegalovirus Infection

E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹