2015 American Transplant Congress » Poster Session D: Costimulation and Signaling in Lymphocytes

Date: Tuesday, May 5, 2015

Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-6:30pm: 2B4 Expression on Human CD4+ Memory T Cells Is Associated With Functional Impairment

C. Chen, S. Laurie, J. Lyons, C. Coopersmith, M. Ford.

5:30pm-6:30pm: Absence of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and 2 Modifies Adaptive Immune Responses

S. Kasimsetty, A. Shigeoka, D. McKay.

5:30pm-6:30pm: Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates

K. Hotta, A. Aoyama, P. Putheti, Y. Yamada, T. Ohura, R. Colvin, B. Cosimi, G. Benichou, T. Strom, T. Kawai.

5:30pm-6:30pm: Aldosterone Acts Directly On T Cells, and Promotes Production of Inflammatory Cytokines

J. Bagley, S. Begum, J. Iacomini.

5:30pm-6:30pm: Alloimmune Regulation and Long-Term Allograft Survival Induced by Short-Term Administration of Chinese Medicine Cornus Officinalis and Cuscuta Sinensis Lam

Z. Dai, Y. Zeng, X. Liu, Z. Chuan.

5:30pm-6:30pm: Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells

M. Uchiyama,^1,2,3 E. Yin,^3,4 X. Jin,^3,5 T. Shimokawa,¹ H. Yagita,² M. Niimi.³

5:30pm-6:30pm: CD28 Saturation by FR104, a Non-Activating CD28 Antagonist Fab in a Non-Human Primate Cardiac Allograft Model

W. Sun,¹ A. Azimzadeh,¹ G. Braileanu,¹ T. Zhang,¹ D. Amoako,¹ L. Burdorf,¹ B. Vanhove,² R. Pierson III.

5:30pm-6:30pm: CTLA4Ig Administered During T-Cell Priming Negates de novo Alloantibody Responses and Modulates Recall Antibody Production

G. Wu, I. Kim, N.-N. Chai, S. Jordan, A. Klein.

5:30pm-6:30pm: Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin

J. Sullivan,¹ D. Wilkes,² T. Mohanakumar,³ W. Burlingham.¹

5:30pm-6:30pm: Characterization of Peripheral Blood T and B Cells of Sensitized Kidney Transplant Recipients With Long Term Stable Graft Function

N. Galante,¹ M. Fernandes,¹ F. Agena,¹ A. Triboni,¹ G. Freitas,¹ A. Aguirre,¹ W. Nahas,¹ V. Coelho,² E. David-Neto.¹

5:30pm-6:30pm: Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells

I. Kim, N.-N. Chai, S. Jordan, A. Klein, G. Wu.

5:30pm-6:30pm: Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients

M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 S. Brouard,^1,2 N. Degauque.^1,2

5:30pm-6:30pm: Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease

D. Nayak, M. Sharma, Z. Xu, A. Gelman, T. Mohanakumar.

5:30pm-6:30pm: Expression Patterns of Neuropilin-1 On T Cells and a Potential Role in Transplantation

E. Lee, H. Kim, G. Demirci.

5:30pm-6:30pm: IFNγ Is Required for nTreg Afferent Lymphatic Migration

S. Ahmad, Y. Xiong, C. Brinkman, J. Bromberg.

5:30pm-6:30pm: Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset

T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹

5:30pm-6:30pm: Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)

E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹

5:30pm-6:30pm: Inhibition of T Cell Metabolism Reveals a New Approach to Preventing Graft Rejection

C.-F. Lee,^1,2 Y.-C. Lo,² G. Furtmüller,³ B. Oh,³ V. Andrade-Oliveira,² A. Thomas,⁴ G. Brandacher,³ J. Powell.²

5:30pm-6:30pm: Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells

G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.

5:30pm-6:30pm: Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients

M. Dürr, J. Liu, K. Budde.

5:30pm-6:30pm: Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P

C. Brinkman, Y. Xiong, J. Bromberg.

5:30pm-6:30pm: Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

A. Arterbery,¹ M. Martinez,² S. Lobritto,² Y. Avitzur,³ K. Raddassi,¹ M. Kleinewietfeld,⁴ U. Ekong.¹

5:30pm-6:30pm: Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury

K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹

5:30pm-6:30pm: OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)

F. Schena,¹ C. Curci,¹ F. Sallustio,¹ M. Trpevski,¹ G. De Palma,¹ M. Fiorentino,² M. Rossini,² M. Quaglia,³ E. Bozzola,³ S. Zanini,⁴ L. Furian,⁴ A. Toscano,⁵ E. Gallo,⁶ L. Gesualdo,² P. Stratta,³ P. Rigotti,⁴ F. Citterio,⁵ L. Biancone.⁶

5:30pm-6:30pm: Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments

S. Laurie, D. Liu, M. Ford.

5:30pm-6:30pm: Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch

M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 D.-A. Laplaud,^1,2 S. Brouard,^1,2 C. Pecqueur,⁴ N. Degauque.^1,2

5:30pm-6:30pm: T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice

S. Noel,¹ M. Martina,² S. Bandapalle,¹ S. Reddy,³ L. Racusen,² A. Hamad,² H. Rabb.¹

5:30pm-6:30pm: T-bet Directs nTreg Homing Into Draining Lymph Nodes by Regulation of Specific Migration and Adhesion Receptors

Y. Xiong, S. Ahmad, D. Iwami, C. Brinkman, J. Bromberg.

5:30pm-6:30pm: The Immunosuppressive Effect of CTLA4Ig Monotherapy Depends On the Presence of Tregs Only at Suboptimally Low Doses

C. Schwarz,¹ L. Unger,¹ B. Mahr,¹ K. Aumayr,² N. Pilat,¹ K. Hock,¹ A. Farkas,¹ I. Kristo,¹ T. Wekerle.¹

5:30pm-6:30pm: The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells

G. Stallone,¹ R. Federica,¹ P. Pontrelli,² M. Accetturo,² A. Oranger,² M. Gigante,² G. Castellano,² A. Schena,² M. Fiorentino,² B. Infante,¹ L. Gesualdo,² G. Grandaliano.¹

5:30pm-6:30pm: Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

S. Iida,¹ T. Suzuki,² K. Tanabe,¹ A. Valujskikh,³ R. Fairchild,³ R. Abe.²

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