2020 American Transplant Congress » Poster Session D: B-cell / Antibody /Autoimmunity

3:30pm-4:00pm

ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level

I. Adam, B. Motyka, K. Tao, L. West

3:30pm-4:00pm

Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh

3:30pm-4:00pm

B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation

S. Hasgur, R. Fan, A. Valujskikh

3:30pm-4:00pm

Characterization of CpG-stimulated, Tlr Regulatory, and Expanded Regulatory B Cells by RNA-Seq

Q. Fu, G. C. Rickert, K. Lee, G. Huai, K. Deng, N. Feeney, N. Tanimine, A. Cuenca, S. Deng, J. F. Markmann

3:30pm-4:00pm

Characterization of Non HLA Antibodies in Kidney Transplant Recipients

S. Rodriguez Ramirez¹, S. Clotet-Freixas¹, C. Mcevoy¹, M. Kotlyar², I. Jurisica², A. Chruscinski¹, A. Konvalinka³

3:30pm-4:00pm

Characterization of a Novel CD8⁺ B Cell Subset in Monkeys Tolerant of Heart Allografts

J. A. Morrissette¹, K. Pruner¹, S. Lee¹, J. Paster¹, W. Sommer¹, J. O¹, I. Hanekamp¹, P. Sage², G. Benichou¹, J. C. Madsen³

3:30pm-4:00pm

Erythropoietin Reduces Alloantibody Formation by Inhibiting T Follicular Helper Cells

C. Cantarelli¹, C. Guglielmo², S. Bin², A. Cumpelik², C. Donadei³, L. Anderson⁴, S. Hartzell², K. Budge², M. Haverly², A. Angeletti³, G. La Manna³, E. Fiaccadori¹, U. Maggiore¹, P. Heeger², P. Cravedi²

3:30pm-4:00pm

Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo

G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹

3:30pm-4:00pm

HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bet^hiB Cell Response to Vaccine

A. Nellore, G. R. Martens, J. T. Killian, J. Houp, E. Zumaquero, B. Mousseau, J. Bradley, F. Zhou, P. A. Goepfert, F. E. Lund

3:30pm-4:00pm

Impact of PD1, PDL1 Gene Polymorphisms on Allo-Immune Responses after Kidney Transplantation

H. Yamane, Y. Tanaka, M. Ohira, H. Tahara, K. Ide, H. Ohdan

3:30pm-4:00pm

Irf8-Relevant Mechanism in B Cell Regulation In Vitro

Q. Fu¹, K. Deng², H. Yang¹, J. F. Markmann², S. Deng¹

3:30pm-4:00pm

Isolation of Preformed Antibodies from Whole Blood by Integrating Acoustics and Microfluidics in Sensitized Animal Model

J. Kwun¹, Y. Gu², M. Manook¹, M. Wu¹, J. Yoon¹, S. Knechtle¹, T. J. Huang²

3:30pm-4:00pm

Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts

V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh

3:30pm-4:00pm

Natural Antibodies and Left Ventricular Assist Device Complications

S. B. See¹, D. Onat², E. Hittesdorf³, F. McDougan⁴, M. Yuzefpolskaya², V. K. Topkara², Y. Naka⁵, H. Takayama⁵, K. Takeda⁵, G. Milligan⁶, D. Wencker⁶, S. Hall⁶, M. Askar⁶, P. Kimball⁴, G. Wagener³, P. C. Colombo², E. Zorn¹

3:30pm-4:00pm

Naïve B Cells Regulation by TLR-Breg Cells In Vitro

Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann

3:30pm-4:00pm

Passenger Lymphocyte Syndrome Due to Anti-Rh(D) Reactivity after Kidney Transplantation: A Case Report

S. Nemr¹, S. Bani Hani¹, E. Klohe², C. Gresens³, S. Desmond¹, O. Ojogho¹

3:30pm-4:00pm

Profiling Non-HLA Antibodies in Antibody-Mediated Rejection Following Cardiac Transplantation

S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino³, P. C. Colombo³, L. Addonizio², M. A. Farr³, E. Zorn¹

3:30pm-4:00pm

Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection

S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. M. Baldwin, R. L. Fairchild

3:30pm-4:00pm

Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice

B. Anjum, B. Motyka, I. Adam, J. Fersovich, M. Sulzer, J. Pearcey, K. Tao, L. J. West

3:30pm-4:00pm

Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation

Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle

3:30pm-4:00pm

Transcriptomic Profiling of Paired Serum and Biopsy Samples from FSGS Patients

C. Kuscu¹, M. Kiran², A. Wolen¹, C. Kuscu¹, A. Bajwa¹, J. Eason¹, D. Maluf¹, E. Akalin³, V. Mas¹