2020 American Transplant Congress » Poster Session C: Immunosuppression Preclinical Studies

3:30pm-4:00pm

A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease

S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson

3:30pm-4:00pm

Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model

R. Schmitz, M. S. Mulvihill, Z. W. Fitch, T. How, F. Leopardi, A. D. Kirk

3:30pm-4:00pm

Blocking Complement Component C3 in a Sensitized Nonhuman Primate Model of Kidney Allotransplantation

R. Schmitz¹, P. M. Schroder¹, Z. W. Fitch¹, A. Y. Choi¹, M. Manook¹, J. Yoon¹, A. Farris², E. S. Reis³, J. D. Lambris³, J. Kwun¹, S. J. Knechtle¹

3:30pm-4:00pm

Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein

C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan

3:30pm-4:00pm

Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques

B. I. Shaw¹, R. Schmitz¹, D. M. Magnani², F. Leopardi¹, A. D. Kirk¹

3:30pm-4:00pm

ESAT-6, A Novel Protein Originally Produced by M. Tuberculosis, Inhibits Central Memory CD8+ T Cell Generation and Allograft Rejection

F. Qiu, S. Ye, H. Liu, Z. Dai

3:30pm-4:00pm

Graft Perfusion with an Hsp90 Inhibitor Prolongs Graft Survival in Murine Heart Transplantation by Modulating Expression of Cyclin-Dependent Kinases and the Senolytic Effect

T. Tanaka, T. Maehana, N. Masumori

3:30pm-4:00pm

Granulocyte-Colony Stimulating Factor (G-CSF) and Granulocyte-Macrophage CSF (GM-CSF) Administration Enriches for Highly Suppressive CD4⁺CD45RA^–Foxp3^hi Cells in Leukapheresis Products of Rhesus Monkeys

K. Sasaki, Y. Wang, L. Lu, J. Hughes, V. Vujevich, A. W. Thomson, M. B. Ezzelarab

3:30pm-4:00pm

Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy

M. Ma, K. Brayman, P. Chhabra

3:30pm-4:00pm

Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells

H. J. Jang

3:30pm-4:00pm

Synergistic Anticancer Effect of Metformin in Combination with Immunosuppressant on Hepatocellular Carcinoma Cell Lines

S. Suh¹, Y. Choi¹, K. Lee²

3:30pm-4:00pm

Targeting CD4⁺ T Cell Metabolism Prolongs Graft Survival Age-Specifically

Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius

3:30pm-4:00pm

Treatment Strategies to Suppress Donor Specific Antibodies: Highlights from a Decade of Research Experience in a Mouse Model of Allo-Sensitization

I. Kim, G. Wu, N. Chai, T. Brennan, A. Klein, S. Jordan