2017 American Transplant Congress » Poster Session B: Ischemic Injury and Organ Preservation Session II

6:00pm-7:00pm

AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.

S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.

6:00pm-7:00pm

Combined Perfusion of Liver and Kidney Enhances the Protective Effects of Normothermic Perfusion on Donation After Cardiac Death Porcine Livers.

Z. Guo, F. Ji, X. He, G. Chen.

6:00pm-7:00pm

DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.

L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2

6:00pm-7:00pm

Dual Role for Caspase-3 in the Regulation of Tubular and Microvascular Damage Post-Renal Ischemia-Reperfusion Injury.

B. Yang,^1,2,3 S. Lan,^1,2,3 N. Patey,^1,3,4 J. Turgeon,^1,3 M. Dieudé,^1,3 M.-J. Hébert.^1,2,3

6:00pm-7:00pm

EPOR₂/ßcR₂-Independendent Effects of Low-Dose Epoetin-a in Porcine Liver Transplantation.

L. Kebschull,¹ F. Becker,¹ L. Theilmann,¹ B. Heitzplatz,² W. Uennigmann,¹ H. Spiegel,¹ D. Palmes.¹

6:00pm-7:00pm

Effects of the Gut-Liver Axis on Ischemia-Mediated Hepatocellular Carcinoma Recurrence in the Mouse Liver.

L. Orci,¹ S. Lacotte,¹ V. Delaune,¹ G. Oldani,¹ F. Slits,¹ C. Rossetti,² L. Rubbia-Brandt,³ P. Morel,¹ C. Toso.¹

6:00pm-7:00pm

Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.

D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4

6:00pm-7:00pm

Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.

F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.

6:00pm-7:00pm

Gene Editing of Keap1/Nrf2 in Human T Cells Using CRISPR-Cas9 to Improve Outcome from Ischemia Reperfusion Injury and Other T Cell Mediated Diseases.

S. Noel,¹ S. Lee,¹ M. Sadasivam,² A. Hamad,² H. Rabb.¹

6:00pm-7:00pm

Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.

D. Murken,¹ D. Aufhauser Jr,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ W. Hancock,² M. Levine.¹

6:00pm-7:00pm

Impact of STEEN vs Gelofusine as Perfusate During Normothermic Ex Vivo liver Perfusion on Outcome of Pig Liver Transplantation.

I. Linares, D. Kollmann, J. Echeverri, M. Kaths, R. Rosales, C. Bruguera, M. Hamar, P. Urbanellis, S. Ganesh, N. Selzner, M. Selzner.

6:00pm-7:00pm

Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.

Z. Rao,¹ H. Zhou,² X. Pan,¹ M. Gao,¹ Z. Wang,¹ J. Sun,¹ C. Liu,¹ Z. Ding.¹

6:00pm-7:00pm

Measurement of Dissolved Oxygen by ¹⁹F MRI of Microcapsules Implanted IP in Non-Human Primates.

S. Safley,¹ M. Graham,² M. Garwood,³ K. Papas,⁵ B. Weegman,^3,4 G. Barber,¹ E. Lin,¹ J. Leisen,⁷ A. Sambanis,⁶ B. Hering,² C. Weber.¹

6:00pm-7:00pm

Myeloid HO-1 Regulates M2 Macrophage Activation in Liver Ischemia-Reperfusion Injury (IRI).

K. Nakamura,¹ M. Zhang,² S. Kageyama,¹ B. Ke,¹ R. Sosa,³ E. Reed,³ A. Zarrinpar,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹

6:00pm-7:00pm

Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.

P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹

6:00pm-7:00pm

Novel Application of Localized Nanodelivery of Anti-IL6 Protects Organ Transplant from Ischemia Reperfusion Injuries.

M. Uehara,¹ Z. Solhjou,¹ B. Bahmani,¹ O. Maarouf,¹ T. Ichimura,² C. Brooks,² W. Xu,¹ V. Kasinath,¹ N. Banouni,¹ A. Elkhal,³ I. Guleria,² M. McGrath,¹ S. Tullius,³ R. Abdi.¹

6:00pm-7:00pm

Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.

D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5

6:00pm-7:00pm

Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.

A. Cimeno,¹ J. Powell,¹ B. French,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.

6:00pm-7:00pm

Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.

H. Wang,¹ S. Yue,¹ M. Ni,¹ R. Busittil,¹ J. Kupiec-Weglinski,¹ L. Lu,² Y. Zhai.¹

6:00pm-7:00pm

Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.

M. Zaouali,¹ A. Panisello Roselló,¹ T. Carbonell,² A. Garcia-Gil,³ A. Lopez,⁴ R. Adam,⁴ J. Rosello-Catafau.¹

6:00pm-7:00pm

TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.

T. Fujii, S. Duarte, R. Busuttil, A. Coito.