2019 American Transplant Congress » Poster Session B: Biomarkers, Immune Monitoring and Outcomes

Date: Sunday, June 2, 2019

Time: 6:00pm-7:00pm

Location: Hall C & D

Session Type: Poster Session

Meeting: 2019 American Transplant Congress

6:00pm-7:00pm: A Prognostic Drug Development Tool to Assess the Transplantability at the Time of Listing for Kidney Transplant Candidates

S. Kawakita¹, L. Hidalgo-Semlek², J. L. Beaumont¹, J. Lee², M. J. Everly¹

6:00pm-7:00pm: A Robust and Portable Protocol for RNA Isolation from Urinary Cells for Noninvasive Monitoring of Kidney Allograft Recipients

B. Botticelli, S. Albakry, E. Edusei, H. Yang, M. Cassidy, C. Li, C. Snopkowski, M. Lubetzky, J. Lee, D. Dadhania, T. Muthukumar, M. Suthanthiran

6:00pm-7:00pm: Absence of Non Alcoholic Fatty Liver Disease in Allografts from Morbidly Obese Donors: A Marker for Success?

M. MacConmara, A. Mufti, S. Hanish, T. Kerr, P. Vagefi, C. Hwang

6:00pm-7:00pm: Broadly Profiling the Activation Status of Circulating Immune Cells in Chronic Active Antibody Mediated Rejetion Reveals Increased CD38 and CD16 Expression on Monocytes and NK Cells

K. Sablik, N. Litjens, M. Klepper, M. Betjes

6:00pm-7:00pm: CMV-Specific Cell-Mediated Immunity Early after Transplantation Discriminates R+ Transplant Patients at Risk of CMV Infection among Different Solid Organ Transplants

M. Jarque¹, A. Cachero², E. Garcia-Romero³, L. Lladó², C. Baliellas², C. Diez³, E. Melilli⁴, J. Fabregat², J. Gonzalez-Costello³, O. Bestard⁴

6:00pm-7:00pm: CNV Screening For End-stage Renal Disease

C. E. Fishman, B. Chang, A. Shaked, B. J. Keating

6:00pm-7:00pm: Characterization of Circulating T-cell Specific Exosomes during Acute Rejection in Murine Heart Transplantation Model

R. Hu¹, V. Korutla¹, L. Korutla¹, S. Rostami¹, A. Habertheuer¹, S. Addya², J. Harmon¹, P. Zielinski¹, S. Reddy¹, A. Freas¹, C. Ram¹, A. Naji¹, P. Vallabhajosyula¹

6:00pm-7:00pm: Chemokine Ligand 14 is a Novel Therapeutic Target in Kidney Fibrosis

S. Lee¹, Y. Kim¹, J. Moon¹, H. Lee¹, S. Han¹, J. Lee², R. Cha³, D. Kim¹, C. Lee⁴, K. Kim⁵, Y. Kim¹, S. Yang⁶

6:00pm-7:00pm: Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection

E. Crespo¹, A. Vidal¹, A. Sefrin², P. Fontova¹, M. Stein², H. Volk², J. Grinyó³, P. Reinke², N. Lloberas¹, O. Bestard³

6:00pm-7:00pm: Comparison between Urine and Blood NGAL for Early Prediction of Delayed Graft Function in Adult Kidney Transplant Recipients: A Systematic Review and Meta-Analysis

Y. Li, Y. Li, L. Yan, H. Wang, X. Wu, J. Tang, L. Wang, Y. Shi

6:00pm-7:00pm: Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats

J. Kim, Y. Lee, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black

6:00pm-7:00pm: Development of De Novo DSA after Kidney Transplant Correlates with Low Quantity of Peripheral Blood “Antibody-Suppressor” CD8⁺T Cells

J. Zimmerer¹, M. Basinger¹, B. Ringwald¹, R. Pelletier¹, A. Rajab¹, A. El-Hinnawi¹, M. Abdel-Rousoul², H. Parekh³, K. Washburn¹, G. Bumgardner¹

6:00pm-7:00pm: Dissecting The Role Of Donor Acute Kidney Injury On Molecular Responses Post-transplantation

S. Bontha¹, D. Maluf¹, E. Akalin², L. Gallon³, J. Eason⁴, V. Mas⁵

6:00pm-7:00pm: Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?

K. D. Bera¹, J. Tabak², M. L. Lo Faro¹, R. J. Ploeg¹

6:00pm-7:00pm: Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome

M. Meneghini¹, E. Crespo², M. Niemann³, A. Torija², E. Melilli⁴, M. Jarque², N. Montero⁴, J. Cruzado¹, J. Grinyo¹, O. Bestard¹

6:00pm-7:00pm: Evaluation of Liver Function and Biomarkers Predicts Tumor Progression in Treatment-Naïve Hepatocellular Carinoma Patients

K. Nunez, T. Sandow, S. Robertson, P. Thevenot, A. Cohen

6:00pm-7:00pm: First UK Experience of the Molecular Microscope (MMDX™) in the Kidney Transplant Clinic

C. Lawrence¹, S. Thiru², A. Manoj¹, S. Fluck¹

6:00pm-7:00pm: Functional Dependence, Access to Kidney Transplantation and Waitlist Mortality

A. Muzaale¹, N. Chu¹, H. Ying¹, S. Norman², S. Sison¹, D. Segev¹, M. McAdams-Demarco¹

6:00pm-7:00pm: Global Analysis of Fc-gamma Receptors Binding Capacity of Human Leukocyte Antigen Donor Specific Antibody

E. S. Woodle, A. Girnita

6:00pm-7:00pm: High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation

T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹

6:00pm-7:00pm: Higher Post-Transplant CXCL13 Correlates with the Occurrence of Infection within 1 Year after Kidney Transplantation

Y. Li¹, Y. Li¹, L. Yan¹, L. Wang¹, Y. Shi², J. Tang¹

6:00pm-7:00pm: HuR Dictates HO-1 Expression, Modulates Inflammation and Influences Recipient Outcomes in Liver Transplant Patients

K. J. Dery, K. Nakamura, K. Kadono, H. Hirao, S. Kageyama, T. Ito, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

6:00pm-7:00pm: ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation

G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell

6:00pm-7:00pm: Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study

C. Jimenez¹, J. M. Portoles², D. Blánquez³, L. Arribas³, A. Ortega⁴, T. Diez⁵, I. Portero⁶

6:00pm-7:00pm: Impact of a Novel Digital Medicine Program on Adherence and Utilization in Pediatric Transplant Patients

S. Sullivan¹, K. N. Triplett¹, C. Sacks², M. Tran², D. M. Desai³

6:00pm-7:00pm: Increased Ratio of Circulating Tfh for Tfr Cells in Chronic Renal Allograft Dysfunction: A Pilot Study

L. Yan, Y. Li, Y. Li, X. Wu, X. Wang, L. Wang, Y. Shi, J. Tang

6:00pm-7:00pm: Long-Term Exposure to Particulate Matter Air Pollution and the Risk of Graft Failure and Mortality in Kidney Transplant Recipients

Y. Kim¹, S. Kwon¹, J. Park², J. Lee³

6:00pm-7:00pm: Metabolomic Study Of Sarcopenia In Patients Prior To Liver Transplantation

S. Ries,¹, N. J. Skill¹, E. Campbell¹, R. Daniel², C. A. Kubal¹, M. S. Richard¹, M. A. Maluccio¹

6:00pm-7:00pm: Multi-Center Validation of TruGraf V2 – A Peripheral Blood Diagnostic for Subclincal Kidney Rejection

C. Marsh¹, S. Kurian¹, C. Schieve², R. Heilman³, M. Stegall⁴, S. Rose², J. Case¹, J. Friedewald⁵, M. Abecassis⁵, R. First²

6:00pm-7:00pm: Need of a New Formula to Estimate Creatinine Clearance in Immediate Post Kidney Transplant Period with Functioning Allograft

A. B. Jain¹, U. Farooq², A. Brooks¹, T. Dohi¹, F. Butt¹, Z. Kadry¹

6:00pm-7:00pm: Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation

G. Queipo¹, M. Fonsecha-Sanchez¹, J. Sanchez¹, L. Garcia¹, M. Carmona², E. Villanueva¹, G. Melendez¹, L. Morales-Buenrostro³, M. Alamilla¹

6:00pm-7:00pm: Normothermic Ex-Situ Liver Perfusion Parameters of Liver Viability in a Porcine Model of Liver Transplantation with Marginal Grafts

I. Linares-Cervantes¹, J. Echeverri¹, S. Cleland¹, M. Kaths¹, R. Rosales¹, T. Goto¹, D. Kollmann¹, M. Hamar¹, P. Urbanellis¹, L. Mazilescu¹, S. Ganesh¹, O. Adeyi¹, P. Yip¹, B. Bojko², P. Gorynzka², K. Gorynski², D. Grant¹, N. Selzner¹, M. Wasowicz¹, M. Selzner¹

6:00pm-7:00pm: Paradoxical Differential Post-transplant Rates Of Change Of Serum Proteins In Pediatric Liver Patients With Evidence For A Novel Sarcopenic-dependent Serum Protein Stimulating Factor

C. M. Schmidt¹, J. Molleston², G. S. Rao², C. A. Kubal¹, S. Atoa¹, R. S. Mangus¹

6:00pm-7:00pm: Patient Reported Side Effects Associated with Reduced Quality of Life after Living Donor Kidney Transplant

J. Peipert, J. C. Caicedo-Ramirez, K. Ensor, J. Friedewald, M. Abecassis, D. Cella, D. Ladner, Z. Butt

6:00pm-7:00pm: Personality Traits of Liver Transplant Candidates – Unappreciated Challenges

D. Ladner¹, J. Lai², A. N. Hall¹, E. D. Bastarache¹, A. Daud¹, T. Bogg³, A. Lebsack¹, T. Kalume¹, D. Mroczek¹

6:00pm-7:00pm: Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion

Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford

6:00pm-7:00pm: Post-Transplant Lymphopenia is Associated with Higher Risk of Graft Failure, Death and Viral Infections

A. Dujardin¹, M. Lorent², C. Kerleau¹, S. Brouard³, M. Giral¹

6:00pm-7:00pm: Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection

P. Schroder¹, J. S. Yi¹, K. J. Weinhold¹, C. Chan², M. Joshi³, C. Walters³, J. Kwun¹, S. J. Knechtle¹

6:00pm-7:00pm: Pre-Treatment Lymphocyte Status in HCC Patients Associates with DEB-TACE Response and Correlates with Increased Regulatory Immune Cells

K. Nunez¹, T. Sandow², S. Robertson¹, P. Thevenot¹, A. Cohen¹

6:00pm-7:00pm: Predicting Risk of Cytomegalovirus with Viral-Antigen-Specific CD154+ T-cells after Liver or Intestine Transplantation

C. Ashokkumar, K. Soltys, M. Green, G. Mazariegos, G. Bond, K. Jones, A. Rzempoluch, M. Zaccagnini, P. Sethi, B. W. Higgs, R. Sindhi

6:00pm-7:00pm: Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function

K. L. Mine¹, T. B. Mourão¹, C. Felipe², G. F. Rampim¹, J. O. Medina-Pestana², H. Tedesco-Silva², M. Gerbase-DeLima¹

6:00pm-7:00pm: Studying the Association of Melanocortin Receptor-4 Gene Polymorphism and Renal Transplant Rejection

F. Yilmaz¹, R. Abdi¹, B. J. Keating², V. R. Mas³

6:00pm-7:00pm: Subclinical Antibody Mediation Rejection in Stable Kidney Recipients with De Novo Donor Specific Antibodies and Correlation with Donor Derived Cell Free DNA Testing

A. P. Bregman, E. J. Stites, J. Gralla, A. Wiseman, J. E. Cooper

6:00pm-7:00pm: The Molecular Profile of Kidney Allografts Unveil Specific Biomarkers for Subclinical Acute Rejection (SAR). Towards an Early Detection and a Targeted Treatment

S. N. Cox, S. Chiurlia, F. P. Schena

6:00pm-7:00pm: The Negative Costimulatory Pd-1/pd-l1 Pathway Is Upregulated In Early Cell-mediated Rejection

T. Kurashige, R. Khedraki, K. Keslar, N. Dvorina, W. Baldwin

6:00pm-7:00pm: The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection

N. M. van Besouw¹, L. Yan¹, R. de Kuiper¹, M. Klepper¹, D. Reijerkerk¹, M. Dieterich¹, D. L. Roelen², F. H. Claas², M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹

6:00pm-7:00pm: The Value of SCS Perfusate Biomarkers for Predicting DGF of DCD Donor Kidneys

X. Li, W. Wang, X. Zhang

6:00pm-7:00pm: Torque Teno Virus is a Prognostic Biomarker for Acute Biopsy-Proven Alloreactivity in Kidney Transplants

K. Doberer

6:00pm-7:00pm: Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients

L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹

6:00pm-7:00pm: Urinary Podocin mRNA as Predictor of Renal Allograft Function Decline

A. Naik¹, J. Aqeel¹, D. Cibrik², M. Samaniego³, L. Wickman¹, S. Wang¹, M. Chowdhury¹, R. Wiggins¹

6:00pm-7:00pm: Use of Anti-Vimentin Antibodies as a Possible Marker for Graft Dysfunction Following Renal Transplant, a Prospective Study

E. Acosta¹, T. Divanyan¹, D. Patel¹, F. Jourd'heuil², D. Jourd'heuil², R. Lopez-Soler³

6:00pm-7:00pm: Use of TruGraf Serial Testing for Confirming Stability in Kidney Transplant Patients with Stable Renal Function

V. Peddi¹, C. Schieve², S. Rose², M. First²

6:00pm-7:00pm: Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial Outcomes: Proteomic Analysis of Perfusates from Livers Undergoing Normothermic Machine Liver Perfusion Reveals Biomarkers Predictive of Graft Viability and Post-Transplant Complications

S. Afford¹, L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza⁴, H. Mergental⁵

6:00pm-7:00pm: miRNA Signatures as Prediction Tool for DSA Development and Rejection

M. Hamdorf¹, L. M. Rebellato², K. P. Briley², M. J. Everly¹

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