2018 American Transplant Congress » Poster Session A: Innate Immunity; Chemokines, Cytokines, Complement

5:30pm-7:30pm

In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury

I. Linares,¹ A. Bartczak,¹ K. Farrokhi,¹ D. Kollmann,¹ M. Kaths,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,² P. Yip,³ M. Selzner,¹ N. Selzner.¹

5:30pm-7:30pm

C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms

J. Horwitz, D. Mathern, P. Heeger.

5:30pm-7:30pm

CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes

H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹

5:30pm-7:30pm

CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion

R. Davis, Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, A. Barbas.

5:30pm-7:30pm

Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy

S. Cai,¹ J. Miao,² A. Chandraker.¹

5:30pm-7:30pm

Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury

S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.

5:30pm-7:30pm

Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function

V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³

5:30pm-7:30pm

Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates

B. Wiegmann,¹ R. BellmasSanz,² C. Neudörfl,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke,¹ C. Falk.²

5:30pm-7:30pm

Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation

C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹

5:30pm-7:30pm

Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis

M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹

5:30pm-7:30pm

Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice

S. Concors,¹ D. Murken,¹ D. Aufhauser,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2

5:30pm-7:30pm

Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress

Z. Rao, J. Sun, X. Pan, Z. Chen, H. Sun, P. Zhang, M. Gao, Z. Ding, C. Liu.

5:30pm-7:30pm

Hyperglycemia-Triggered ATF6-CHOP Pathway Exacerbates Liver Ischemia/Reperfusion Injury: Immunomodulation by Regulating β-Catenin Signaling

J. Rao,^1,2 C. Yang,¹ Y. Hu,¹ S. Yang,¹ Y. Xia,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.^1,2

5:30pm-7:30pm

Hyperglycemia-Triggered S1P/SIPR3signaling Exacerbates Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization

J. Rao,^1,2 Y. Hu,¹ C. Yang,¹ S. Yang,¹ F. Cheng,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,^1,2 L. Lu.^1,2

5:30pm-7:30pm

In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice

L. Lin, J. Wang, L. Cendales, A. Kirk, T. Brennan.

5:30pm-7:30pm

Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation

R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹

5:30pm-7:30pm

Ischemic Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury in Mice via Heme Oxygenase-1-Mediated Autophagy

J. Hwang,² H. Choi,¹ M. Kim,² K. Jun,² K. Kown,² S. Park,² J. Kim,² I. Moon.²

5:30pm-7:30pm

Leukocytes from Recipients with Severe Primary Graft Dysfunction after Lung Transplant Adoptively Transfer Alloreactivity to Vessel Grafts Trans Vivo

A-.K. Knoefel,¹ T. Siemeni,¹ N. Madrahimov,¹ W. Sommer,¹ M. Avsar,¹ L. Ahrens,¹ I. Tudorache,¹ A. Haverich,¹ C. Falk,² G. Warnecke.¹

5:30pm-7:30pm

NK Cells with a Lung-Resident Phenotype Represent the Most Prominent Donor Passenger Leukocyte Subset after Clinical Lung Transplantation

C. Falk,¹ R. BellmasSanz,¹ B. Wiegmann,² A-.M. Hitz,¹ K. Bläsing,¹ C. Neudörfl,¹ I. Tudorache,² C. Kühn,² M. Avsar,² A. Haverich,² G. Warnecke.²

5:30pm-7:30pm

Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function

Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.

5:30pm-7:30pm

Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction

L. Garcia-Covarrubias,¹ G. Queipo,² M. Fonseca,² D. Alcantara,¹ P. Prieto,¹ H. Diliz,¹ A. Garcia,¹ H. Hinojosa,¹ A. Cicero,¹ G. Melendez,³ M. Alamilla,³ R. Lascurain,⁴ V. Soto.⁵

5:30pm-7:30pm

Peptides Encoded by EBV Latent Cycle Proteins Affect NK Cell Reactivity

B. Mbiribindi, C. Romero Moreno, C. Esquivel, O. Martinez, S. Krams.

5:30pm-7:30pm

Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4⁺ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

G. Dwyer,¹ L. Mathews,¹ A. Lucas,¹ B. Blazar,² H. Turnquist.¹

5:30pm-7:30pm

Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells

H. Zhou,¹ Z. Rao,¹ R. Liu,¹ S. Zhou,¹ J. Rao,¹ J. Gu,¹ H. Lu,¹ Y. Xia,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹

5:30pm-7:30pm

Significant Difference between Proteasome and Immunoproteasome Inhibition in Acute Kidney Injury

F. Han, C. Ding, Y. Zhao, P. Tian.

5:30pm-7:30pm

Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity

C. Yang, T. Zhu.

5:30pm-7:30pm

TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion

S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.

5:30pm-7:30pm

The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis

J. An,¹ Y. Kim,² M. Yu,² J. Lee,¹ C. Lee,³ Y. Kim,² S. Yang.⁴