2019 American Transplant Congress » Poster Session A: B-cell / Antibody /Autoimmunity

5:30pm-7:30pm

CD19⁺Tim-1⁺ Regulatory B Cells Mediate the Balance of Th17 Treg to Decrease the Level of Donor-Specific Antibodies in Mice Secondary Skin Transplantation Model

Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

5:30pm-7:30pm

AMD3100 and Low-Dose FK506 Prevent De Novo Donor Specific Antibody Formation and Rejection in a Sensitized Kidney Transplantation Model

A. R. Ahmadi, L. Qi, R. N. Wesson, A. M. Cameron, Z. Sun

5:30pm-7:30pm

APRIL^-/-/BLyS^-/- Deplete Antibody Secreting Cells and Alloantibody Production in Sensitized Antibody Mediated Rejection Model

N. Bath, B. Verhoven, N. Wilson, R. Redfield III

5:30pm-7:30pm

B Cell Immunophenotypes in Transplantation

M. Cascalho¹, M. de Mattos-Barbosa², E. A. Farkash³, J. L. Platt²

5:30pm-7:30pm

BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses

N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan

5:30pm-7:30pm

Comparison of Isolated Transplant Glomerulopathy with Chronic Antibody-Mediated Rejection in Regards to Endothelial-to-Mesenchymal Transition and Graft Survival

B. H. Ozdemir¹, F. N. Ozdemir², G. Moray³, M. Haberal³

5:30pm-7:30pm

Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection

S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino¹, P. C. Colombo³, L. J. Addonizio², M. A. Farr³, E. Zorn¹

5:30pm-7:30pm

Differential Expression of B Cell Activating Factor in Experimental Models of Acute and Chronic Active Antibody-Mediated Rejection

S. Reese, N. Wilson, L. Ptak, R. Redfield, A. Djamali, S. E. Panzer

5:30pm-7:30pm

Effects of Standard Drug Immunosuppression on Peripheral Transitional B Cells and Gene Expression in Non-Human Primates

A. Bean¹, J. Paster¹, K. Pruner¹, J. O¹, W. Sommer², K. Robinson³, I. Hanekamp¹, G. Benichou¹, J. Madsen¹

5:30pm-7:30pm

IL-1β and IL-6 Facilitate T Cell Reconstitution in Heart Allograft Recipients Treated with Anti-Thymocyte Globulin

S. Hasgur, R. Fan, A. Valujskikh

5:30pm-7:30pm

Identification of Antibodies Reactive to Vimentin in a Rat Kidney Transplant Model of Chronic Antibody-Mediated Rejection

S. Reese, N. Wilson, L. Ptak, J. Sullivan, W. Burlingham, A. Djamali, S. E. Panzer

5:30pm-7:30pm

Iguratimod Attenuates the Production of Donor Specific Antibody by Inducing CD19⁺Tim-1⁺ Regulatory B Cells and Imbalance of Th17 Treg

Z. Wang, S. Fei, H. Chen, Z. Han, L. Sun, J. Tao, X. Ju, M. Zheng, R. Tan, M. Gu

5:30pm-7:30pm

In Vitro Model for Detection of HLA Antibodies from Long Lived Plasma Cells

M. Merzkani¹, N. Moore¹, X. Benavides¹, B. Smith¹, W. Park¹, A. Bentall¹, K. Medina², M. Gandhi³, M. Stegall¹

5:30pm-7:30pm

Increasing Expression of B-cell Maturation Antigen during the Development of Recall Antibody Responses: A Prospective Pharmaceutical Target for B-cell Suppression?

G. Wu, I. Kim, N. Chai, A. Klein, S. Jordan

5:30pm-7:30pm

Interleukin-27 is Required for Donor Specific Antibody Production in Response to Heart Allograft Transplantation

M. Nicosia, S. Miyairi, R. Fan, A. Beavers, V. Gorbacheva, A. Valujskikh

5:30pm-7:30pm

JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively

H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹

5:30pm-7:30pm

Kidney Allograft Recipient Absence of Myeloperoxidase Decreases Donor-Specific Antibody Titers and Attenuates Antibody-Mediated Allograft Rejection

S. Miyairi, N. Dvorina, A. Valujuskikh, W. M. Baldwin 3rd, R. L. Fairchild

5:30pm-7:30pm

Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent

I. Adam¹, B. Motyka², L. West³

5:30pm-7:30pm

Natural Antibodies and Left Ventricular Assist Device Complications

S. B. See¹, A. Pinsino², R. Shihab¹, N. Kunimune¹, D. Onat², E. Hittesdorf³, A. R. Garan², V. K. Topkara², Y. Naka⁴, H. Takayama⁴, K. Takeda⁴, P. Colombo², M. Yuzefpolskaya², G. Wagener³, E. Zorn¹

5:30pm-7:30pm

Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

S. Kanangat¹, I. Kurbegovic-Skaljic², D. Cimbaluk², M. Oppermann², S. Jensik³, E. Hollinger³, O. Olaitan⁴, R. DeCresce²

5:30pm-7:30pm

TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection

M. Garcia de Mattos-Barbosa¹, E. A. Farkash², J. L. Platt¹, M. Cascalho¹

5:30pm-7:30pm

Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis

J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹