2019 American Transplant Congress » Poster Session A: Acute Rejection

5:30pm-7:30pm

A Novel Ex Vivo Normothermic Perfusion Model of Human Antibody Mediated Rejection

P. Chandak¹, B. L. Phillips¹, R. Uwechue¹, C. J. Callaghan¹, O. Shaw², T. Maggs³, L. Woodford³, D. Veniard³, R. Perera⁴, K. Parmar³, B. Hunt⁵, D. Bennett⁶, N. Kessaris¹, A. Dorling⁷, N. Mamode¹

5:30pm-7:30pm

Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters

C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹

5:30pm-7:30pm

BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival

J. Zhang, Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

5:30pm-7:30pm

Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection

R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker

5:30pm-7:30pm

Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG

R. Schmitz¹, M. S. Mulvihill¹, P. M. Schroder¹, Z. Fitch¹, F. Leopardi¹, D. Magnani², J. Kwun¹, S. J. Knechtle¹, A. D. Kirk¹

5:30pm-7:30pm

Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes

K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹

5:30pm-7:30pm

Donor-derived Cell-free Dna In Donor Specific Antibody Positive Kidney Transplant Recipients

D. Cheng¹, X. Li², T. Jiang², H. Liu², Y. Zhou³, H. Shi³

5:30pm-7:30pm

Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation

J. Guiteras¹, L. De Ramon¹, N. Bolaños¹, M. Franquesa², M. Gomà³, J. Cruzado⁴, N. Lloberas¹, J. Grinyó⁴, J. Torras⁴

5:30pm-7:30pm

Effect of Chronic Kidney Disease on Allo-Immune Response in Mice

P. D. Winterberg¹, H. Li¹, M. E. Wagener², M. L. Ford²

5:30pm-7:30pm

Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway

M. Rahman, M. Sharma, S. Angara, M. Smith, R. Bremner, T. Mohanakumar

5:30pm-7:30pm

Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants

A. Harner¹, Y. Wang², X. Fang², R. Lassiter¹, T. D. Merchen¹, S. Ho³, S. Nahman Jr²

5:30pm-7:30pm

Gut Microbiome And Acute Rejection After Kidney Transplantation

H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²

5:30pm-7:30pm

Immunomics of Renal Allograft Acute T-Cell Mediated Rejection Biopsies of Tacrolimus- and Belatacept- Treated Patients

M. van der Zwan¹, C. C. Baan¹, R. C. Colvin², R. N. Smith², R. A. White², D. N. Ndishabandi², A. L. Nigg¹, T. P. van den Bosch¹, G. N. de Graav¹, M. C. Clahsen-van Groningen¹, D. A. Hesselink¹

5:30pm-7:30pm

Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8⁺ T Cell Apoptosis in a Rat Liver Transplantation Model

X. Chen¹, Q. Yang¹, X. Li², Y. Deng¹, G. Chen¹, G. Wang¹

5:30pm-7:30pm

Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants

S. Pineda¹, A. Ravoor², O. Bestard³, M. Sarwal¹, M. Sirota²

5:30pm-7:30pm

Molecular Microscope Proves i-IFTA Lack of Specificity

A. Perkowska-Ptasinska¹, M. Ciszek², D. Deborska-Materkowska¹, A. Debska-Slizien³, P. F. Halloran⁴, M. Myslak⁵

5:30pm-7:30pm

Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection

A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal

5:30pm-7:30pm

Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation

D. T. Tran, C. Atkinson, S. N. Nadig

5:30pm-7:30pm

Quantitative Proteome Profiling in T Cell-Mediated Rejection

L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴

5:30pm-7:30pm

RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection

B. Dooley¹, A. Verma², R. Ding¹, C. Li¹, C. Snopkowski¹, H. Yang¹, B. Botticelli¹, S. Albakry¹, E. Edusei¹, T. Muthukumar¹, M. Lubetzky¹, D. Dadhania¹, J. Lee¹, O. Elemento², M. Suthanthiran¹

5:30pm-7:30pm

Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation

S. Tanaka¹, J. M. Gauthier¹, Y. Terada¹, T. Takahashi¹, W. Li¹, R. Higashikubo¹, A. Y. Tong¹, V. Puri¹, A. S. Krupnick², A. E. Gelman¹, D. Kreisel¹

5:30pm-7:30pm

Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies

M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran

5:30pm-7:30pm

Single Cell Analysis of Kidney Allograft Rejection

C. M. Castro-Rojas¹, K. M. Roskin², C. G. Moore², B. Abu Jawdeh³, N. Salomonis², R. R. Alloway⁴, E. Woodle⁴, D. A. Hildeman¹

5:30pm-7:30pm

Single Cell RNA-seq Analysis of Antibody-Mediated Rejection Reveals Endothelial – Pericyte NOTCH Signaling

A. F. Malone, A. Chadha, H. Wu, S. Ramakrishnan, E. Donnelly, B. D. Humphreys

5:30pm-7:30pm

T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection

R. Reindl-Schwaighofer¹, J. Vetter², J. Weinberger³, S. Schaller², A. Heinzel¹, G. Gualdoni¹, C. Aschauer¹, K. Jelencsics¹, K. Hu¹, S. Winkler², R. Oberbauer¹

5:30pm-7:30pm

Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection

J. Callemeyn¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, W. Gwinner³, M. Essig⁴, D. Anglicheau⁵, P. Marquet⁶, M. Naesens¹