2019 American Transplant Congress » Poster Session A: Acute Rejection

Date: Saturday, June 1, 2019

Time: 5:30pm-7:30pm

Location: Hall C & D

Session Type: Poster Session

Meeting: 2019 American Transplant Congress

5:30pm-7:30pm: A Novel Ex Vivo Normothermic Perfusion Model of Human Antibody Mediated Rejection

P. Chandak¹, B. L. Phillips¹, R. Uwechue¹, C. J. Callaghan¹, O. Shaw², T. Maggs³, L. Woodford³, D. Veniard³, R. Perera⁴, K. Parmar³, B. Hunt⁵, D. Bennett⁶, N. Kessaris¹, A. Dorling⁷, N. Mamode¹

5:30pm-7:30pm: Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters

C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹

5:30pm-7:30pm: BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival

J. Zhang, Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

5:30pm-7:30pm: Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection

R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker

5:30pm-7:30pm: Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG

R. Schmitz¹, M. S. Mulvihill¹, P. M. Schroder¹, Z. Fitch¹, F. Leopardi¹, D. Magnani², J. Kwun¹, S. J. Knechtle¹, A. D. Kirk¹

5:30pm-7:30pm: Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes

K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹

5:30pm-7:30pm: Donor-derived Cell-free Dna In Donor Specific Antibody Positive Kidney Transplant Recipients

D. Cheng¹, X. Li², T. Jiang², H. Liu², Y. Zhou³, H. Shi³

5:30pm-7:30pm: Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation

J. Guiteras¹, L. De Ramon¹, N. Bolaños¹, M. Franquesa², M. Gomà³, J. Cruzado⁴, N. Lloberas¹, J. Grinyó⁴, J. Torras⁴

5:30pm-7:30pm: Effect of Chronic Kidney Disease on Allo-Immune Response in Mice

P. D. Winterberg¹, H. Li¹, M. E. Wagener², M. L. Ford²

5:30pm-7:30pm: Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway

M. Rahman, M. Sharma, S. Angara, M. Smith, R. Bremner, T. Mohanakumar

5:30pm-7:30pm: Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants

A. Harner¹, Y. Wang², X. Fang², R. Lassiter¹, T. D. Merchen¹, S. Ho³, S. Nahman Jr²

5:30pm-7:30pm: Gut Microbiome And Acute Rejection After Kidney Transplantation

H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²

5:30pm-7:30pm: Immunomics of Renal Allograft Acute T-Cell Mediated Rejection Biopsies of Tacrolimus- and Belatacept- Treated Patients

M. van der Zwan¹, C. C. Baan¹, R. C. Colvin², R. N. Smith², R. A. White², D. N. Ndishabandi², A. L. Nigg¹, T. P. van den Bosch¹, G. N. de Graav¹, M. C. Clahsen-van Groningen¹, D. A. Hesselink¹

5:30pm-7:30pm: Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8⁺T Cell Apoptosis in a Rat Liver Transplantation Model

X. Chen¹, Q. Yang¹, X. Li², Y. Deng¹, G. Chen¹, G. Wang¹

5:30pm-7:30pm: Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants

S. Pineda¹, A. Ravoor², O. Bestard³, M. Sarwal¹, M. Sirota²

5:30pm-7:30pm: Molecular Microscope Proves i-IFTA Lack of Specificity

A. Perkowska-Ptasinska¹, M. Ciszek², D. Deborska-Materkowska¹, A. Debska-Slizien³, P. F. Halloran⁴, M. Myslak⁵

5:30pm-7:30pm: Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection

A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal

5:30pm-7:30pm: Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation

D. T. Tran, C. Atkinson, S. N. Nadig

5:30pm-7:30pm: Quantitative Proteome Profiling in T Cell-Mediated Rejection

L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴

5:30pm-7:30pm: RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection

B. Dooley¹, A. Verma², R. Ding¹, C. Li¹, C. Snopkowski¹, H. Yang¹, B. Botticelli¹, S. Albakry¹, E. Edusei¹, T. Muthukumar¹, M. Lubetzky¹, D. Dadhania¹, J. Lee¹, O. Elemento², M. Suthanthiran¹

5:30pm-7:30pm: Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation

S. Tanaka¹, J. M. Gauthier¹, Y. Terada¹, T. Takahashi¹, W. Li¹, R. Higashikubo¹, A. Y. Tong¹, V. Puri¹, A. S. Krupnick², A. E. Gelman¹, D. Kreisel¹

5:30pm-7:30pm: Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies

M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran

5:30pm-7:30pm: Single Cell Analysis of Kidney Allograft Rejection

C. M. Castro-Rojas¹, K. M. Roskin², C. G. Moore², B. Abu Jawdeh³, N. Salomonis², R. R. Alloway⁴, E. Woodle⁴, D. A. Hildeman¹

5:30pm-7:30pm: Single Cell RNA-seq Analysis of Antibody-Mediated Rejection Reveals Endothelial – Pericyte NOTCH Signaling

A. F. Malone, A. Chadha, H. Wu, S. Ramakrishnan, E. Donnelly, B. D. Humphreys

5:30pm-7:30pm: T Cell Repertoire of Tissue Infiltrating T-cells at Time of Rejection

R. Reindl-Schwaighofer¹, J. Vetter², J. Weinberger³, S. Schaller², A. Heinzel¹, G. Gualdoni¹, C. Aschauer¹, K. Jelencsics¹, K. Hu¹, S. Winkler², R. Oberbauer¹

5:30pm-7:30pm: Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection

J. Callemeyn¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, W. Gwinner³, M. Essig⁴, D. Anglicheau⁵, P. Marquet⁶, M. Naesens¹

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