2022 American Transplant Congress » Immunoregulation and Tolerance

5:30pm-5:40pm

Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

5:40pm-5:50pm

Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies

A. S. Kurt¹, P. Ruiz¹, E. Kodela¹, G. Lombardi¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹

5:50pm-6:00pm

T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism

T. J. Borges¹, N. Murakami², I. T. Lape¹, R. B. Gassen¹, K. Liu¹, L. V. Riella¹

6:00pm-6:10pm

Intrinsic DEPTOR Activity Modulates Treg Subset Differentiation

J. Wedel¹, M. Maslyar¹, B. Alsairafi¹, S. Kong², D. M. Briscoe¹

6:10pm-6:20pm

Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²

6:20pm-6:30pm

Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response

Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹

6:30pm-6:40pm

Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies

L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²

6:40pm-6:50pm

Treg Tissue Stability Depends on Adenosine Receptor Driven Lymphatic Endothelial Cell Responses

V. Saxena¹, W. Piao¹, L. Li¹, M. W. Shirkey¹, R. Lakhan¹, S. Walden², K. L. Hippen², B. R. Blazar², J. S. Bromberg¹

6:50pm-7:00pm

Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance

L. Wang¹, G. J. Babcock², W. W. Hancock³