2017 American Transplant Congress » Concurrent Session: Xenotransplant

2:30pm-2:42pm

Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.

J. Stern,¹ S. Kofman,¹ P. Alonso-Guallart,¹ E. Berglund,¹ M. Danton,¹ J. Weiner,¹ D. Ayares,² R. Hawley,¹ K. Yamada,¹ D. Sachs,¹ M. Sykes,¹ A. Griesemer.¹

2:42pm-2:54pm

Addition of hEPCR.hCD55.hTFPI.hCD47 Modulates Multi-Lineage Cell Sequestration and Coagulation Activation by GalTKO.hCD46 Transgenic Pig Livers Perfused Ex Vivo with Human Blood.

A. Cimeno,¹ L. Burdorf,¹ D. Parsell,¹ C. Phelps,² D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.¹

2:54pm-3:06pm

Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.

J. Shah, M. Patel, N. Elias, I. Rosales, N. Navarro-Alvarez, M. Hertl, A. Cosimi, R. Colvin, J. Markmann, D. Sachs, P. Vagefi.

3:06pm-3:18pm

Orthotopic Liver Transplantation of Xenogeneic Livers Repopulated with Autologous Hepatocytes: Proof of Normal Function and Consistent Survival.

G. Oldani, S. Lacotte, L. Orci, V. Delaune, C. Toso.

3:18pm-3:30pm

Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.

A. Singh,¹ S. Agbor-Enoh,² J. Chan,¹ S. Groham,² P. Corcoran,¹ B. Lewis,³ M. Thomas,³ D. Ayares,⁴ K. Horvath,¹ H. Valantine,² M. Mohiuddin.¹

3:30pm-3:42pm

CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.

S. Kim, L. Higginbotham, D. Mathews, C. Breeden, A. Stephenson, C. Larsen, M. Ford, J. Tector, A. Adams.

3:42pm-3:54pm

CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.

S. Kim,¹ L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ A. Stephenson,¹ C. Larsen,¹ M. Ford,¹ J. Tector,² A. Adams.¹