2015 American Transplant Congress » Concurrent Session: New Immunosuppression Strategies: Primate Models

Date: Tuesday, May 5, 2015

Time: 4:00pm-5:30pm

Location: Room 119-A

Session Type: Concurrent Session

Meeting: 2015 American Transplant Congress

4:00pm-4:12pm: CD28-Directed Therapy Prolongs Survival in a Non-Human Primate Kidney Transplant Model

L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ W. Wakwe,¹ C. Larsen,¹ S. Nadler,² A. Adams.¹

4:12pm-4:24pm: Selective Blockade of the CD28/B7/CTLA4 Pathway With Monovalent Anti-CD28 Antibodies Versus Targeting of B7 With CTLA4-Ig, in Non-Human Primate Kidney Allograft

S. Ville,¹ N. Poirier,^1,2 B. Vanhove,^1,2 G. Blancho.¹

4:24pm-4:36pm: Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys

H. Guo,¹ L. Lu,¹ R. Wang,² H. Abdulkerim,² R. Keith,² A. Thomson,¹ M. Ezzelarab.¹

4:36pm-4:48pm: Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts

M. Tonsho,¹ G. Benichou,¹ R. Smith,² R. Colvin,² J. Madsen.^1,3

4:48pm-5:00pm: Costimulation Blockade and Bortezomib to Desensitize Rhesus Macaque and Prolong Renal Allograft Survival

J. Kwun, C. Burghuber, E. Page, A. Gibby, N. Iwakoshi, S. Knechtle.

5:00pm-5:12pm: Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments

L. Burdorf,¹ E. Rybak,¹ T. Zhang,¹ D. Harris,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ E. Sievert,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹

5:12pm-5:24pm: Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates

T. Oura, K. Hotta, J. Lei, J. Markmann, A. Dehnadi, G. Benichou, B. Cosimi, T. Kawai.

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