2017 American Transplant Congress » Concurrent Session: B Cells in Alloimmunity

Date: Sunday, April 30, 2017

Time: 2:30pm-4:00pm

Location: E350

Session Type: Concurrent Session

Meeting: 2017 American Transplant Congress

2:30pm-2:42pm: Characterization of a B Lymphocyte Signature Predictive of Chronic Lung Allograft Dysfunction.

C. Brosseau,^1,2 M. Durand,^1,2 E. Durand,^1,2 J. Loy,² A. Foureau,² P. Lacoste,² P.-J. Royer,² A. Magnan,² S. Brouard.¹

2:42pm-2:54pm: B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.

D. Zwick, K. Ayasoufi, R. Fan, V. Gorbacheva, K. Keslar, R. Fairchild, A. Valujskikh.

2:54pm-3:06pm: Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.

B. Ezekian, J. Kwun, M. Manook, K. Freischlag, V. Curfman, E. Branum, J. Park, J. Yi, S. Jordan, S. Knechtle.

3:06pm-3:18pm: Effective Targeting Plasma Cells with Daratumumab (Anti-CD38) and Mozobil (Anti-CXCR4) in a Sensitized Non-Human Primate Model.

J. Kwun,¹ B. Ezekian,¹ M. Manook,¹ E. Branum,¹ V. Curfman,¹ J. Park,^1,2 K. Freishlag,¹ J. Yoon,¹ S. Knechtle.¹

3:18pm-3:30pm: Dual Targeting of Costimulation and Proteasome to Desensitize and Prolong Graft Survival of Sensitized Nonhuman Primates.

J. Kwun,¹ C. Burghuber,¹ M. Manook,¹ B. Ezekian,¹ J. Park,^1,2 K. Freishlag,¹ J. Yoon,¹ N. Iwakoshi,³ A. Farris,⁴ S. Knechtle.¹

3:30pm-3:42pm: Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

M. Manook,^1,2 J. Kwun,¹ J. Yoon,¹ K. Samy,¹ A. MacDonlad,¹ H. Xu,¹ R. Smith,³ S. Sacks,³ A. Dorling,³ N. Mamode,² S. Knechtle.¹

3:42pm-3:54pm: TACI Polymorphisms Associated with De Novo Alloantibodies in Humans and Allograft Rejection in Mice.

J. Platt,¹ E. Farkash,² A. Lefferts,¹ M. Samaniego,³ M. Cascalho.¹

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