2022 American Transplant Congress » Chronic Organ Rejection

5:30pm-5:40pm

TEMRA CD8 T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2x4 Receptor-Dependent Proinflammatory and Migratory Responses

G. Tilly¹, T. Doan-Ngoc¹, O. Bonizec¹, C. Masset², R. Danger³, P. Guérif¹, S. Bruneau¹, J. Harb¹, M. Giral¹, C. Pecqueur⁴, S. Brouard¹, N. Degauque¹

5:40pm-5:50pm

Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis

Z. Gui¹, W. Zijie², M. Zheng³, R. Tan³, M. Gu⁴

5:50pm-6:00pm

Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration

A. Buxeda¹, L. Llinàs-Mallol¹, J. Gimeno², D. Redondo-Pachón¹, C. Arias-Cabrales¹, C. Burballa¹, A. Puche², M. Pérez-Sáez¹, J. Pascual³, M. Crespo¹

6:00pm-6:10pm

Strada Deficiency Results in Inhibition of Tumor Suppressor Gene Liver Kinase B1 Resulting in Epithelial Mesenchymal Transition Leading to Chronic Murine Lung Allograft Rejection

M. Rahman, S. Bansal, R. Ravichandran, A. Sureshbabu, W. Lie, S. Perincheri, M. Smith, R. Bremner, T. Mohanakumar

6:10pm-6:20pm

One Nuclei at a Time: Decoding Kidney Allograft Fibrosis by Single Nuclei RNA-Sequencing

J. McDaniels¹, A. Shetty¹, C. Kuscu², C. Kuscu², E. Bhardi¹, T. Rousselle¹, C. Drachenberg³, M. Talwar⁴, J. Eason⁵, T. Muthukumar⁶, D. Maluf¹, V. Mas¹

6:20pm-6:30pm

B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation

M. Bueno¹, N. F. Smirnova², K. Riemondy³, P. Suresh¹, M. Brown¹, X. Wang¹, S. Collins⁴, J. Sembrat¹, M. Koenigshoff¹, M. Snyder¹, J. McDyer¹, O. Eickelberg¹

6:30pm-6:40pm

Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection

M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵

6:40pm-6:50pm

Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α

Z. Gui¹, W. Zijie², M. Zheng³, M. Gu¹, R. Tan³

6:50pm-7:00pm

Rejection After Liver Transplantation: What Can We Learn from Transcriptomic Analysis?

H. J. Braun¹, D. Amara², A. Zarinsefat¹, G. Szabo¹, Z. Laszik¹, P. Stock¹, N. Ascher¹