2022 American Transplant Congress » Acute Rejection

5:30pm-7:00pm

Association Between Allograft Gene Expression and Acute Cellular Rejection Grade in Heart Transplant Recipients

A. Kao¹, K. Haffey², K. T. Gondi³, J. Linard², C. Knutson², K. Morgan², L. Teterina², S. Williams², K. Oreschak⁴, H. Zhang⁴

5:30pm-7:00pm

CD8⁺ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation

G. Cohen, M. A. Kallarakal, S. M. Krummey

5:30pm-7:00pm

Chronic Ethanol Exposure Prolongs Murine Allograft Survival

D. Swift, M. Ford, W. Kitchens

5:30pm-7:00pm

Concordance of Kidney and Pancreas Rejection on Protocol and for Cause Biopsy in Simultaneous Kidney Pancreas Transplantation

P. Budhiraja, R. Heilman, H. Khamash, A. Jaramillo, D. Ramon, H. Me, J. Ninan, S. Reddy, s. S. Misra, H. Chakkera

5:30pm-7:00pm

Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One-Month Values Have Any Prognostic Significance?

B. K. Sharda¹, M. Garner¹, A. Farney¹, G. Orlando², J. Rogers², C. Jay³, A. Daniel¹, A. Guiterrez¹, N. Sakhovskaya¹, R. Stratta¹

5:30pm-7:00pm

Early Detection of Acute Rejection by Urine QSant is Not Confounded by Post-Transplant Time

C. Baan¹, S. Ghosh², J. Verhoeven¹, D. Hesselink¹, K. Boer¹, M. Sarwal²

5:30pm-7:00pm

LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody

A. Boshart¹, S. Farkona¹, S. Clotet-Freixas¹, C. McEvoy¹, J. Murphy¹, S. Crome², A. Konvalinka³

5:30pm-7:00pm

Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes

J. Callemeyn¹, B. Lamarthée¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, M. Rabant⁵, A. Senev¹, T. Vaulet⁶, C. Tinel¹, M. Naesens¹

5:30pm-7:00pm

Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes

A. Ahmed¹, L. Allegretti², C. Rebello³, B. Kinsella³, K. Guo³, S. Park⁴, J. Friedewald³

5:30pm-7:00pm

Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection

Y. Mitsui¹, D. Ueda¹, S. Miyairi¹, N. Dvorina¹, K. S. Keslar¹, A. Valujskikh¹, B. William¹, R. Fairchild²

5:30pm-7:00pm

Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft

D. Okada, S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. Baldwin, R. Fairchild

5:30pm-7:00pm

Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy

A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴

5:30pm-7:00pm

Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health

M. Rao¹, M. Amouzgar¹, J. T. Harden¹, M. Lapasaran¹, A. Trickey¹, B. Armstrong², J. Odim³, T. Debnam³, C. Esquivel¹, S. C. Bendall¹, O. Martinez¹, S. M. Krams¹

5:30pm-7:00pm

The Impact of Early Graft Infiltrating TCF-1^LowPD-1^HighCD8⁺ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model

T. Ota¹, R. Goto¹, T. Harada¹, Y. Ganchiku¹, M. Zaitsu¹, A. Forgioni¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹

5:30pm-7:00pm

Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection

R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹

5:30pm-7:00pm

p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

H. Tsuda¹, A. Valujskikh², R. Fairchild³