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2018 American Transplant Congress
Metabolic Regulation of Neuropeptides Induces Weight Loss and is Linked to Prolongation of Allograft Survival
M. Quante,^1,2 T. Heinbokel,¹ K. Minami,¹ Y. Nian,¹ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston, MA; ²Department of General, Visceral and Transplant Surgery, Tuebingen Unversity Hospital, Tuebingen, Germany.
Obesity has become a common comorbidity among transplant recipients that is linked to inferior transplant outcome through far-reaching effects on metabolism, inflammation and immunity. Increasingly,…
2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
Y. Wang,¹ X. Fang,¹ D. Kleven,¹ C. Ho,² S. Nahman,^1,3 T. Merchen.¹
¹Augusta University, Augusta, GA; ²Gift of Life Michigan, Ann Arbor, MI; ³Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…
2018 American Transplant Congress
Providing Transplant Candidates with Patient-Specific Public Reports about Programs That Transplant Patients Like Them
C. Schaffhausen,^1,4 M. Bruin,³ S. Chu,³ A. Matas,⁵ J. Lake,⁶ W. Kim,^7,4 S. Biggins,⁸ J. Snyder,^2,4 B. Kasiske,^1,4 A. Israni.^1,2
¹Department of Medicine, Hennepin County Medical Center (HCMC), University of Minnesota (UMN), Minneapolis, MN; ²Department of Epidemiology and Community Health, UMN, Minneapolis, MN; ³College of Design, UMN, Minneapolis, MN; ⁴Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ⁵Department of Surgery, UMN, Minneapolis, MN; ⁶Division of Gastroenterology, Hepatology, and Nutrition, UMN, Minneapolis, MN; ⁷Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; ⁸Division of Hepatology, University of Washington, Seattle, WA.
The Scientific Registry of Transplant Recipients (SRTR) provides federally mandated program-specific reports (PSR) to the public. Previous patient feedback indicated interest in tailoring search information…
2018 American Transplant Congress
Evaluating Displays of Program Waitlist Mortality on Public Search Results
C. Schaffhausen,^1,4 M. Bruin,³ S. Chu,³ A. Matas,⁵ J. Lake,⁶ W. Kim,^7,4 S. Biggins,⁸ J. Snyder,^2,4 B. Kasiske,^1,4 A. Israni.^1,2,4
¹Department of Medicine, Hennepin County Medical Center (HCMC), University of Minnesota (UMN), Minneapolis, MN; ²Department of Epidemiology and Community Health, UMN, Minneapolis, MN; ³College of Design, UMN, Minneapolis, MN; ⁴Scientific Registry of Transplant Recipients, Minneapolis Medial Research Foundation, Minneapolis, MN; ⁵Department of Surgery, UMN, Minneapolis, MN; ⁶Division of Gastroenterology, Hepatology, and Nutrition, UMN, Minneapolis, MN; ⁷Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; ⁸Division of Hepatology, University of Washington, Seattle, WA.
The Scientific Registry of Transplant Recipients (SRTR) provides federally mandated program-specific transplant data to the public. SRTR has developed new website materials to provide more…
2018 American Transplant Congress
Providing Transplant Candidates with Guidance about Differences in Acceptance Criteria across Programs
C. Schaffhausen,^1,4 M. Bruin,³ S. Chu,³ A. Matas,⁵ J. Lake,⁶ W. Kim,^4,7 S. Biggins,⁸ J. Snyder,^2,4 B. Kasiske,^1,4 A. Israni.^1,2
¹Department of Medicine, Hennepin County Medical Center (HCMC), University of Minnesota (UMN), Minneapolis, MN; ²Department of Epidemiology and Community Health, UMN, Minneapolis, MN; ³College of Design, UMN, Minneapolis, MN; ⁴Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ⁵Department of Surgery, UMN, Minneapolis, MN; ⁶Division of Gastroenterology, Hepatology, and Nutrition, UMN, Minneapolis, MN; ⁷Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; ⁸Division of Hepatology, University of Washington, Seattle, WA.
The Scientific Registry of Transplant Recipients (SRTR) provides federally mandated program-specific reports (PSR) to the public. Candidate acceptance criteria vary widely across programs for many…
2017 American Transplant Congress
We Wish This Would Never Happen Again! Implementation of an Adverse Event Review System to Improve the Safety of Pediatric Solid Organ Transplant (SOT) Patients.
J. Gossett,¹ M. Lake,¹ J. Bucuvalas,² A. Basu,¹ L. Burkhart,¹ L. Danziger-Isakov,¹ A. Lorts.¹
¹Solid Organ Transplant Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Division of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background: 50% of SOT centers are cited by CMS for inadequate review of adverse events (AE)s. AE reviews are inconsistently performed, rarely cover near misses…
2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
M. Menon, N. Philippe, C. Wei, W. Zhang, J. He, B. Murphy.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…
2017 American Transplant Congress
The TAKE-IT Intervention Improves Medication Adherence in Adolescent Kidney Transplant Recipients.
B. Foster,¹ A. Pai,² S. Furth,³ TAKE-IT Investigators.
¹McGill University, Montreal, Canada; ²Cincinnati Children's Hospital Medical Center, Cincinnati; ³Children's Hospital of Philadelphia, Philadelphia
Poor adherence to immunosuppressive medications limits renal allograft survival. This randomized controlled trial, evaluated whether young kidney transplant recipients administered a behavioral intervention showed greater…
2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
A. Morris, D. Pinelli, D. Liu, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…
2017 American Transplant Congress
Inhibition of Multiple Nodes in the PI3K/Akt/mTOR Pathway Synergistically Suppresses Epstein-Barr Virus B Cell Lymphomas.
A. Sang, G. Ivison, X. Qu, C. Esquivel, S. Krams, O. Martinez.
Division of Abdominal Transplantation, Stanford School of Medicine, Palo Alto, CA
Treating post-transplant lymphoproliferative disorders (PTLD) remains a clinical challenge due to adverse effects such as graft rejection. mTOR inhibitors, including rapamycin (RAPA), have shown both…

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