ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Phenotypic Personalized Medicine: Mechanism-Independent Convergence Into Target Serum Tacrolimus Levels for Optimized Liver Transplant Immunosuppression

    A. Zarrinpar,1 A. Silva,2 D.-K. Lee,3 N. Datta,1 C.-M. Ho,2 D. Ho.3

    1Surgery-Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA; 2Mechanical Engineering, UCLA, Los Angeles, CA; 3Bioengineering, and Oral Biology and Medicine, UCLA, Los Angeles, CA.

    PURPOSE:Immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges and their dosing variability necessitates intensive drug monitoring. This study aimed to use Feedback System Control…
  • 2015 American Transplant Congress

    Tolerant Kidney Transplant Patients Display B Cells With Regulatory Properties

    S. Brouard,1,2 M. Chesneau,1,3 L. Michel,1,2,3 E. Dugast,1,3 A. Chenouard,1,3 A. Pallier,1 D. Baron,1,3 J. Durand,1,3 F. Braza,1,3 P. Guerif,2 D.-A. Laplaud,1,2,3 J.-P. Soulillou,1,2,3 M. Giral,1,2,3 N. Degauque,1,3 E. Chiffoleau,1,3 S. Brouard.1,2

    1INSERM UMR 1064, Nantes, France; 2CHU de Nantes, ITUN, Nantes, France; 3Université de Nantes, Faculté de Médecine, Nantes, France.

    Whereas a B cell transcriptional profile has been recorded for operationally tolerant kidney graft patients, the role that B cells may play in this process…
  • 2013 American Transplant Congress

    Improving Value after Pediatric Liver Transplant: Discharge Practices of High-Performing Centers

    B. Kelly, M. Englesbe, J. Bucuvalas, W. Andrews, J. Mitchell, R. Anand, W. Yin, J. Magee, G. Mazariegos, S. Horslen

    SPLIT Quality Improvement Committee, Nashville; University of Michigan, Ann Arbor; University of Cincinnati, Cincinnati; Children's Mercy Hospital, Kansas City; EMMES Corporation, Rockville; Children's Hospital of Pittsburgh, Pittsburgh; University of Washington, Seattle

    We sought to improve value (outcomes/cost) for the initial hospitalization after pediatric liver transplantation (LT) by identifying variation in length of stay (LOS), a highly…
  • 2013 American Transplant Congress

    Comprehensive Analyses of Inhibitory Effects of the mTOR Inhibitor Everolimus on the Differentiation into Subsets of Human T-Helper Cells and B Cells

    Y. Tanaka, M. Yamashita, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    [Aim] Although the various potential benefits of everolimus over other immunosuppressants in organ transplantation have been described, the precise sensitivity of this drug to differentiation…
  • 2013 American Transplant Congress

    Mesenchymal Stromal Cells Promote Bowel Regeneration after Intestinal Transplantation: Myth to Mucosa

    C. Ceresa, F. Dazzi, R. Ramcharan, S. Reddy, E. Fryer, S. Marley, F. Lee, S. Sinha, P. Friend, A. Vaidya

    Oxford Transplant Centre, Churchill Hospital, Oxford, United Kingdom; Stem Cell Biology, Department of Medicine, Imperial College London, London, United Kingdom; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, United Kingdom

    Aim: To report the first case of use of mesenchymal stromal cells (MSCs) to promote mucosal regeneration in an isolated intestinal transplant recipient who had…
  • 2013 American Transplant Congress

    Subtle Deregulation of Circadian Rhythm in Mice with Partial A20 Knockdown Severely Impacts Lipid Metabolism Following Partial Hepatectomy Causing Defective Regeneration and Increased Lethality

    P. Studer, C. da Silva, E. Csizmadia, D. Candinas, D. Stroka, A. Ma, M. Bhasin, C. Ferran

    Surgery, Beth Israel Deaconess Medical Center, HMS, Boston, MA; Visceral Surgery, University Hospital of Bern, Bern, Switzerland; Medicine, UCSF, San Francisco, CA

    Overexpression of A20 promotes liver regeneration (LR), but contribution of physiologic A20 to LR remains unclear. We performed 2/3 partial hepatectomy (PH) in A20 heterozygous…
  • 2013 American Transplant Congress

    Impact of Transplant Guardian Angels on the Patient Experience, The

    D. Maurer, J. Sherer, R. Shapiro

    Starzl Transplantation Institute, UPMC, Pittsburgh, PA

    Background: A tertiary care facility can be overwhelming to patients and their families when they are called in for transplant. The off-hours nature and lack…
  • 2013 American Transplant Congress

    Fish Oil Diet Overcomes Genetic Predisposition Restoring Hepatocyte Proliferation in Livers of A20 Heterozygous Mice Following Partial Hepatectomy

    C. Da Silva, P. Studer, E. Csizmadia, D. Minussi, K. Daniels, C. Ferran

    Surgery, Beth Israel Deaconess Medical Center - HMS, Boston, MA

    Increased free fatty acids (FA) metabolism following partial hepatectomy (PH) is required to meet energy demands of liver regeneration (LR). Impact of dietary lipid intake…
  • 2013 American Transplant Congress

    Axin2/β-Catenin/Notch1 Sigaling Regulates Innate Immunity in Mouse Model of Liver Ischemia/Reperfusion Injury

    B. Ke, X. Shen, N. Kamo, S. Yue, F. Gao, R. Busuttil, J. Kupiec-Weglinski

    Dumont-UCLA Transplant Ctr, Dept of Surgery, UCLA School of Medicine, Los Angeles, CA

    Background: Axin2 is a multiple function protein involved in many biological pathways, and its overexpression might regulate Β-catenin activity. The Notch signaling is known to…
  • 2013 American Transplant Congress

    NAFLD and Dietary Fatty Acid Composition: The Good, the Bad and the Ugly

    A. Sutter, T. Geng, D. Lewin, K. Chavin, A. Cowart

    Medical University of South Carolina, Charleston, SC

    Background: Nonalcoholic steatohepatitis (NASH) is predicted to become the primary cause of end-stage liver disease necessitating transplantation. However, recurrence of NASH and fibrosis post-transplantation is…
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