ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Clinical Outcomes of Paired Kidney Exchange for Highly Sensitized Renal Transplant Recipients

    M. Grafals, M. Cooper, J. Verbesey, J. Vucci, B. Javaid, O. Timofeeva, S. Rosen-Bronson

    Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC; Histocompatibility Laboratory, Georgetown University Hospital, Washington, DC

    Purpose: A local multicenter paired kidney exchange (PKE) was employed to facilitate identification of compatible donors for highly-sensitized recipients.Methods: Virtual crossmatching was used to identify…
  • 2013 American Transplant Congress

    Predictors of Clostridium Difficile Infection in Liver Transplant Recipients: A 10 Year Single-Center Cohort Study

    C. Mittal, S. Arshad, M. Miceli, I. Bajjoka, L. Brown, M. Abouljoud, M. Ramesh, G. Alangaden

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    Background: Clostridium difficile infection (CDI) is a common cause of morbidity and is associated with increased in-hospital mortality among solid organ transplant recipients. The incidence…
  • 2013 American Transplant Congress

    Prolonged Cold Ischemia Impairs Outcome in Recipients of Donation after Cardiac Death (DCD) Kidney Transplants Despite Machine Perfusion

    S. Paloyo, J. Sageshima, G. Ciancio, L. Chen, A. Mattiazzi, G. Guerra, W. Kupin, D. Roth, S. Ganz, G. Burke III

    Miami Transplant Institute, University of Miami Miller School of Medicine, Miami

    Introduction: The impact of prolonged cold ischemia time (CIT) on kidney grafts donated after circulatory death (DCD) remains unclear when grafts were preserved by hypothermic…
  • 2013 American Transplant Congress

    Donor Brain Death Results in Differentially Modulated Immune Activation in Solid Organs

    P. Ritschl, R. Oberhuber, C. Fabritius, S. Ebner, B. Flörchinger, J. Guenther, A. Nguyen, J. Pratschke, K. Kotsch

    Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany

    Donor brain death (BD) and its pathophysiological changes have been shown to influence graft quality, therefore accelerating the immune response post transplantation. However, detailed information…
  • 2013 American Transplant Congress

    Impact of Prospective Monitoring for Donor Specific Antibodies on Renal Transplant Outcomes with Alemtuzumab Induction

    V. Saini, V. Mudunuri, S. Cohn, G. Reddy, V. Raofi, L. Rocher, A. Koffron, R. Parasuraman, D. Samarapungavan

    MultiOrgan Transplant Program, William Beaumont Hospital, Royal Oak, MI

    Alemtuzumab (AL) induction has been associated with an excess of antibody-mediated rejection (AMR). We initiated a steroid-free AL protocol in August 2009 with prospective monitoring…
  • 2013 American Transplant Congress

    Multicenter Banff Fibrosis Trial: Comparing Visual Assessment of Interstitial Fibrosis in Kidney Biopsies to Computer-Based Image Analysis and Organ Function, The

    A. Farris, S. Chan, J. Climenhaga, R. Colvin, M. Mengel

    Emory University, Atlanta; University of Alberta, Edmonton, Canada; Massachusetts General Hospital, Boston

    Interstitial fibrosis (IF) in renal biopsies is a valuable correlate for organ function, provides prognostic information and is a potential end point in trials.From 15…
  • 2013 American Transplant Congress

    Associations between Clinical, Biochemical Indicators and Anthropometric Measurements with Arterial Stiffness in Renal Transplantation Patients

    M. Erkmen Uyar, E. Tutal, Z. Bal, B. Gurlek Demirci, O. Guliyev, E. Hasdemir, T. Colak, F. Ozdemir Acar, S. Sezer, M. Haberal

    Department of Nephrology, Baskent University, Ankara, Turkey; Department of Internal Medicine, Baskent University, Ankara, Turkey; Department of Nephrology, Baskent University, Istanbul, Turkey; Department of General and Transplantation Surgery, Baskent University, Ankara, Turkey

    Purpose: Arterial stiffness is an independent predictor for cardiovascular mortality. In end stage renal disease cardiovascular risk factors such as age, hypertension and diabetes mellitus…
  • 2013 American Transplant Congress

    ATP-Competitive mTORC1 and 2 Inhibitors Are a Novel Class of Immunosuppressants That Suppress Allograft Rejection

    B. Rosborough, Q. Liu, H. Turnquist, A. Thomson

    Surgery, Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Introduction: The mammalian Target of Rapamycin (mTOR) is the active catalytic subunit of two mTOR-containing complexes – mTOR complex (mTORC) 1 and mTORC2. mTORC1 is…
  • 2013 American Transplant Congress

    MicroRNA Profiling in Ischemia Reperfusion Injury Performed by Next Generation Sequencing in Human Renal Transplantation

    T. Singer, V. Haselmann, U. Benck, R. Eichner, R. Waldherr, S. Porubsky, M. Neumaier, B. Krämer, B. Krüger

    V. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, BW, Germany; Institut für Klinische Chemie, Universitätsmedizin Mannheim, Mannheim, BW, Germany; Pathologisches Institut, Universitätsmedizin Mannheim, Mannheim, BW, Germany

    Objectives: In a variety of (patho-) physiological situations microRNAs, small noncoding RNA fragments of 20-24 bp of length, display import post-transcriptional gene regulators. Current pathology…
  • 2013 American Transplant Congress

    D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

    A. Avolio, J. Halldorson, M. Lirosi, S. Agnes, M. Salizzoni, A. Pinna, M. Spada, L. De Carlis, M. Colledan, G. Gerunda, E. Andorno, G. Rossi, G. Ettorre, A. Risaliti, V. Mazzaferro, M. Rossi, G. Tisone, F. Zamboni, M. Vivarelli, L. Lupo, O. Cuomo, F. Calise, N. Nicolotti, A. Vitale, R. Romagnoli, A. Cucchetti, P. Bonsignore, I. Mangoni, D. Pinelli, R. Montalti, L. Caccamo, G. Vennarecci, D. Nicolini, E. Regalia, U. Baccarani, Q. Lai, T. Manzia, E. Tondolo, M. Rendina, A. Perrella, W. Santaniello, G. Bottino, G. Spagnoletti, G. Mariano, A. Gasbarrini, P. Burra, U. Cillo, the Donor-to-Recipient Italian Liver Transplant (DR2-ILTx) Study Group, Liver Transplant Centers

    Div. of Organ's Transplantation, Catholic University, Rome; , UCSD; , Turin; , Bologna; , Palermo; , Milan; , Bergamo; , Modena; , Genua; , Ancona; , Udine; , Cagliari; , Bari; , Naples; , Padua

    Previous studies demonstrated in US and Italy that D-MELD can be an instrument to optimize donor-2-recipient match (D2Rm) in Liver Transplantation.To characterize prognostic power, peculiarities…
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