ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Targeting of mTORC2 in DC Elicits an Enhanced Pro-Inflammatory Profile and Th17 Alloresponse

    D. Raich-Regue, B. Rosborough, K. Lee, M. Boothby, H. Turnquist, A. Thomson

    Department of Surgery and Department of Immunology, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN

    Mammalian target of rapamycin (mTOR) is an important, yet poorly understood integrative kinase that regulates immune cell function. mTOR functions in two independent complexes,- mTOR…
  • 2013 American Transplant Congress

    Pronounced Impact of Community Risk Factors on Pre-Transplant Kidney Candidate Processes and Outcomes

    E. Heaphy, L. Buccini, T. Srinivas, E. Poggio, D. Goldfarb, S. Flechner, J. Rodrigue, D. Thornton, A. Sehgal, J. Schold

    Cleveland Clinic, Cleveland; Medical University of South Carolina, Charelston; Beth Israel Deaconess Medical Center, Boston; Case Western Reserve University, Cleveland

    IntroductionThere are many potential factors which are associated with patient outcomes beyond traditional clinical and donor characteristics.MethodsWe merged national SRTR data with data aggregated from…
  • 2013 American Transplant Congress

    Fish Oil Diet Overcomes Genetic Predisposition Restoring Hepatocyte Proliferation in Livers of A20 Heterozygous Mice Following Partial Hepatectomy

    C. Da Silva, P. Studer, E. Csizmadia, D. Minussi, K. Daniels, C. Ferran

    Surgery, Beth Israel Deaconess Medical Center - HMS, Boston, MA

    Increased free fatty acids (FA) metabolism following partial hepatectomy (PH) is required to meet energy demands of liver regeneration (LR). Impact of dietary lipid intake…
  • 2013 American Transplant Congress

    French Uncontrolled Donors after Circulatory Arrest (Udcd) Program for Kidney Transplantation: Procurement Procedure Efficiency and 3-Month Survival Results

    C. Antoine, E. Savoye, L. Jacob, G. Cheisson, B. Riou, L. Badet, M. Videcoq, G. Strecker, M. Thuong, National Steering Committee Non Heart Beating Donors Group

    Biomedecine Agency, La Plaine Saint Denis, France; Department of Anesthesia and Critical Care, Saint Louis Hospital, Paris, France; Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, France; Emergency Department, La Pitié Salpêtrière Hospital, Pitié, France; Department of Transplantation, Edouard Herriot Hospital Group, Lyon, France; Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, France; Department of Anesthesia and Critical Care, Huriez Hospital, Lille, France

    The national protocol for the uDCD program restricts the no flow period to <30 min and the total warm ischemia time (WIT) to <150 min.…
  • 2013 American Transplant Congress

    Network Meta-Analysis of Immunosuppressant Regimens in Renal Preservation Following Liver Transplant, A

    F. Bianic, A. Davie, R. Campbell, J. Ricci, C. Escrig, S. Gokhale, J. Lake

    OptumInsight, Nanterre, France; OptumInsight, Uxbridge, United Kingdom; Wellmera AG, Basel, Switzerland; Novartis Pharma AG, Basel, Switzerland; Novartis Healthcare Pvt. Ltd., Hyderabad, India; University of Minnesota, MN

    Background: Long-term exposure to Calcineurin-Inhibitors (CNIs) has been associated with impaired renal function.Objective: To obtain parameter estimates of the relative renal safety of commonly used…
  • 2013 American Transplant Congress

    Interim Analysis of a Double-Blinded Placebo Controlled Trial of IVIG v. IVIG + Rituximab for Desensitization of Highly-HLA Sensitized (PRA >80%) (HS) Deceased Donor (DD) Candidates

    A. Vo, J. Choi, M. Lukovsky, M. Toyoda, S. Ge, J. Kahwaji, A. Peng, R. Villicana, R. Najjar, S. Jordan

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; Transplant Immunology Laboratory, Cedars-Sinai Medical Center

    INTRODUCTION: Desensitization protocols (DES) for HS patients are primarily aimed at living-donor recipients. The efficacy of various DES is not established, especially for DD recipients.…
  • 2013 American Transplant Congress

    Safety and Efficacy of the Levonorgestrel-Releasing Intrauterine System in Transplant Patients

    T. Nizamic, A. Amies Oelschlager, K. Debiec, J. Smith, E. Micks, S. Prager

    Obstetrics and Gynecology, University of Washington, Seattle, WA; Pediatric and Adolescent Gynecology, Seattle Children's Hospital, Seattle, WA

    Introduction: The levonorgestrel intrauterine contraceptive system (LNG-IUS) is safe and effective for contraception, dysmenorrhea, and treatment of heavy menstrual bleeding. Safety and efficacy has been…
  • 2013 American Transplant Congress

    Kidney Transplant Volume and Outcomes Trends in the Era Surrounding Initiation of the Medicare Conditions of Participation

    S. White, D. Zinsser, M. Paul, G. Levine, T. Shearon, V. Ashby, J. Magee, A. Leichtman

    KECC, University of Michigan, Ann Arbor; Dept of Medicine, University of Michigan, Ann Arbor; Dept of Surgery, University of Michigan, Ann Arbor

    Background: In mid-2007, the Centers for Medicare and Medicaid Services (CMS) implemented Conditions of Participation for organ transplant programs, under which programs not attaining specified…
  • 2013 American Transplant Congress

    NK Depletion Reduces Murine Cytomegalovirus Induced Renal Allograft Injury Despite Increased Viral Loads in a Murine Transplant Model

    M. Shimamura, L. Guo, J. George, T. Schoeb, W. Britt

    Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL; Cardiovascular/Thoracic Surgery, University of Alabama at Birmingham, Birmingham, AL; Genetics, University of Alabama at Birmingham, Birmingham, AL

    PURPOSE: NK cell activation is induced by viral infection and has been associated with renal allograft injury in clinical populations and animal models, so this…
  • 2013 American Transplant Congress

    How Do Anhepatic Patients Fair? A Single-Center Experience of Thirteen Patients Requiring Total Hepatectomy and Portocaval Shunting for Severe Hepatic Dysfunction

    K. Lau, A. Zarrinpar, V. Agopian, F. Kaldas, D. Farmer, R. Busuttil

    Department of Surgery, The Dumont-UCLA Liver Transplant Center, Los Angeles, CA

    BACKGROUND/AIMS:Total hepatectomy with portocaval shunting (TH-PS) is a last-resort in patients with severe acute liver dysfunction awaiting liver transplantation (LT). The anhepatic state portends dismal…
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