2013 American Transplant Congress
Deteriorating Quality of Organ Donors, The
PurposeWith the rising disparity between the number of transplants needed and the number of organ donors available, there is an increasing trend of procuring organs…2013 American Transplant Congress
Generic Switch of Tacrolimus in Prevalent Kidney Transplant Recipients
Sheffield Kidney Institute, Sheffield Teaching Hospitals, Sheffield, South Yorkshire, United Kingdom
Introduction:There are limited data on outcomes when switching between tacrolimus brands in prevalent transplant recipients. We have undertaken a monitored switch from Prograf to Adoport…2013 American Transplant Congress
Cardiovascular Risk Profile in Children after Renal Transplantation – Introducing the 4C-T Sub-Study
Hannover Medical School, Hannover, Germany; University of Heidelberg, Heidelberg, Germany
Children with chronic kidney disease (CKD) carry an increased cardiovascular risk up to 1000-fold that of the age-matched general population. The 4C-T (Cardiovascular Comorbidity in…2013 American Transplant Congress
Epitope Analysis of col(V)-Specific Th17 Cell Responses in Lung Transplantation Reveals an HLA-DRB1*1501 Bias in Both Patient and Donor
Surgery, UW Madison, Madison, WI
Fibro-obliterative disease of the airways and vessels is a key element of the chronic rejection process after heart and lung transplantation. Th17 cellular immune responses…2013 American Transplant Congress
Assessment of CMV Antiviral Resistance Mutations in Clinical Samples
Viracor-IBT Laboratories, Lee's Summit, MO
Cytomegalovirus (CMV) infections are a major cause of disease among immunocompromised patients. In this population, prolonged antiviral therapy is often necessary to prevent or treat…2013 American Transplant Congress
Harmonization of an LC-MS/MS Assay for Therapeutic Drug Monitoring of Tacrolimus
Background: Monitoring concentrations of tacrolimus in allograft recipients is considered the standard of care. Trough concentrations are regarded as a good surrogate for tacrolimus exposure.…2013 American Transplant Congress
Tolerogenic Effect of Maternal Microchimerism Is Linked to Semi-Direct Pathway, The
Surgery/Transpantation Division, University of Wisconsin, Madison, WI
Background: In the last decade a semi-direct pathway of alloimune response was described, in which dendritic cells (DC) of the recipient acquire MHC molecules from…2013 American Transplant Congress
Synergism of Complement-Fixing and Non-Complement-Fixing Antibodies to MHC Class I in Pathogenesis of Obliterative Airway Disease: Obligatory Role for the Fc Portion of Immunoglobulins
Washington University, St. Louis, MO
Background: Our previous results demonstrated that both complement fixing (cfABS) as well as non-complement fixing antibodies (ncAbs) to MHC class I result in obliterative airway…2013 American Transplant Congress
Epitope Spreading and Epitope Sharing Are Involved in Acute IgG1 Antibody-Mediated Rejection of a Kidney Transplant with Disparity Only at HLA-DP
University of Toledo, Toledo, OH; University of Pittsburgh, Pittsburgh, PA
Background: Donor-specific alloantibodies (DSA) directed to HLA-DP alone may cause acute antibody-mediated rejection (AMR), especially in re-transplanted patients. Since the origins of such DSA are…2013 American Transplant Congress
Contemporary Analysis of the Effect of Induction Immunosuppression of Survival in Pediatric Lung Transplant Recipients, A
Introduction:The role of induction immunosuppression in lung transplantation (LTX) is varied. In the pediatric population, due to a smaller national incidence and center practice variability,…
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