2013 American Transplant Congress
RBC Transfusions Are Associated with HLA Allosensitization in Patients Awaiting Kidney Transplantation
Introduction: HLA sensitization remains a major barrier to successful kidney transplantation resulting in prolonged wait times, lower transplant rates, and decreased graft survival. This study…2013 American Transplant Congress
MicroRNA Profile Associated with Increased Graft Damage Post Liver Transplantation
Background: Variable graft injury severity post ischemia reperfusion injury (IRI) is observed post liver transplantation (LT). Graft function recovery and performance are linked to this…2013 American Transplant Congress
Long Term Survival of PEGylated Murine Allogenic Islets Using Short Course Immunomodulation
Islet transplantation is a promising therapy for Type 1 diabetes; however, inflammatory and immune host responses lead to islet dysfunction and destruction. Cell surface PEGylation…2013 American Transplant Congress
CD8+ Cytotoxic T Cells Inhibit Alloantibody Production by Killing Alloprimed B Cells
Introduction- While it is well known that CD4+ T cells and B cells collaborate for antibody (Ab) production, our group has recently reported a novel…2013 American Transplant Congress
Effects of Human Alpha-1-Antitrypsin (hAAT) Therapy in a Murine Model of Bilateral Kidney Ischemia-Reperfusion Injury
AIM: Several lines of evidence have demonstrated the anti-inflammatory and cytoprotective effects of alpha-1-Antitrypsin (AAT), the major serum serine-protease inhibitor. The aim of the present…2013 American Transplant Congress
Total Plasma Exchange Does Not Improve Allograft Outcome in Deceased Donor Liver Transplant When Performed for Allograft Dysfunction and Positive Cross-Match
BACKGROUND: Although total plasma exchange (TPE) has been used in ABO incompatibility, and in cases of allograft dysfunction particularly in the presence of a positive…2013 American Transplant Congress
Factors Associated with Renal Dysfunction at 12 Months Following Liver Transplantation
Introduction: Renal dysfunction (RD) before and after liver transplantation (LTx) is a significant predictor of graft failure (GF). We investigated the association of donor and…2013 American Transplant Congress
Novel Role of PI3K Delta Inhibition in Both T and B Cell Activation in Alloimmunity, The
Renal, Brigham and Women's Hospita, Boston, MA
The PI3K family of dual lipid and protein kinases phosphorylates Akt into pAkt, triggering kinase cascades downstream that play a central role in cell proliferation…2013 American Transplant Congress
Use of Software Imaging To Detect Sarcopenia in Lung Transplant Candidates
Background:Abnormal body mass index (BMI) (both <19 and >30 kg/m2) has been associated with worse outcomes in lung transplantation. However, this measurement cannot assess risks…2013 American Transplant Congress
Messenger RNA Levels in Non-Invasive Samples Can Potentially Stratify Risk of Rejection in Renal Transplant Recipients
Identification of molecular biomarkers in blood and urine samples has the potential to revolutionize post transplantation management. Such biomarkers could help risk stratify patients and…
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