ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Serum Aldosterone and Graft Function in Prednisolone-Treated Renal Transplant Recipients

    L. de Vries, M. Kerstens, A. Muller Kobold, I. Kema, J. Sanders, G. Navis, S. Bakker

    Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands

    Background:Short-term outcome after kidney transplantation is excellent, but long-term survival is limited, with chronic transplant dysfunction as important contributor. The mineralocorticoid (MC) aldosterone is essential…
  • 2013 American Transplant Congress

    Probability of a Positive AHG-CDC Crossmatch Is Determined by the Number, Strength, and Specificity of Donor-Specific Antibodies

    J. Lan, G. Espino-Hernandez, J. Gill, P. Keown

    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada

    Background: The factors determining the relationship between donor-specific antibodies (DSA) and the anti-human globulin complement-dependent cytotoxicity crossmatch (AHG-CDC XM) are not clearly defined. Canadian consensus…
  • 2013 American Transplant Congress

    Treatment of Late Onset De Novo Donor Specific Antibody (DSA)-Mediated Pediatric Kidney Transplant Rejection with Bortezomib

    J. Ghata, P. Sindhwani, T. Lewis, M. Turman

    Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Pharmacology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background: In pediatric renal transplantation late onset de novo DSA leading to antibody-mediated rejection (AMR) has a poor prognosis. Our disappointing results with IVIG, rituximab…
  • 2013 American Transplant Congress

    Recipient Death and Graft Loss in Renal Transplantation: The Challenge of Infectious Complications

    M. Cristelli, M. Ivani, F. Pita, F. Ferreira, S. Martins, C. Aldworth, M. Francoso, M. Franco, H. Tedesco, J. Medina- Pestana

    Hospital do Rim e Hipertensão, Sao Paulo, Brazil

    Introduction: The causes of recipient death and renal allograft loss are still under evaluated, and there might be several differences according to the era of…
  • 2013 American Transplant Congress

    Pregnancy Outcomes in Liver Recipients Transplanted for Biliary Atresia

    C. Ramirez, C. Doria, A. Frank, W. Maley, L. Coscia, M. Moritz, V. Armenti

    Surgery, Thomas Jefferson University, Philadelphia, PA; Surgery, Lehigh Valley Health Network, Allentown, PA; National Transplantation Pregnancy Registry, Philadelphia

    The purpose of this study was to describe pregnancy outcomes in female liver recipients who received a transplant due to biliary atresia. Data were collected…
  • 2013 American Transplant Congress

    IL-33 Expands ST2+ Regulatory T Cells Promoting Allograft Survival Directly and Indirectly through Actions on Myeloid Dendritic Cells

    B. Matta, L. Mathews, B. Rosborough, H. Turnquist

    Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; Surgery, University of Pittsburgh, Pittsburgh, PA; Immunology, University of Pittsburgh, Pittsburgh, PA

    Background: IL-33 is an IL-1 cytokine that signals via ST2, which is expressed on both T cells and myeloid cells. IL-33 has been ascribed Th2…
  • 2013 American Transplant Congress

    Role of eGFR Equations in Evaluating Deceased Donors for Kidney Transplantation: Sufficient and Appropriate Outcome Markers?

    M. Burdese, M. Priora, M. Messina, M. Tamagnone, G. Daidola, F. Fop, L. Biancone, G. Segoloni

    University of Turin, Chair of Nephrology, Turin, Italy

    Donor evaluation is crucial in organ allocation for kidney graft, especially with the growing use of ECDs. Donor kidney function is decisive to predict graft…
  • 2013 American Transplant Congress

    Results of a Phase 2 Safety, Efficacy, and Pharmacokinetic Study of TOL-101, an Anti-TCR Monoclonal Antibody for the Prophylaxis of Acute Rejection in Kidney Transplantation

    S. Flechner, S. Mulgaonkar, L. Melton, T. Waid, R. Sung, F. Shihab, A. Wiseman, D. Getts

    Cleveland Clinic Foundation, Cleveland; Barnabas Health, West Orange; Dallas Transplant Institute, Dallas Fort Worth; Tolera Therapeutics Inc, Kalamazoo; University of Kentucky, Lexington; University of Michigan, Ann Arbor; University of Utah, Salt Lake city; University of Colorado, Denver; Northwestern University, Chicago

    Purpose: Induction therapy using anti-lymphocytic antibodies is a potent tool for the prevention of early rejection after kidney transplantation. TOL-101, an IgM monoclonal antibody, with…
  • 2013 American Transplant Congress

    Major Neurological Complications Following Renal Transplantation

    G. Basso, M. Cristelli, D. Bichuetti, M. Franco, A. Baptista, T. Sandes-Freitas, L. Gusuma, P. Gomes, H. Tedesco, J. Medina- Pestana

    Nephrology Division, Hospital do Rim e Hipertensão, Sao Paulo, Brazil

    Introduction: Major neurological complications can add significant morbidity and mortality to renal transplant and have frequencies ranging from 6 to 30% in all transplant recipients.Objective:…
  • 2013 American Transplant Congress

    Thrombin Generation and Platelet Activation in a Xenogenic Lung Perfusion Model Determine Survival of GalTKO.hCD46 Transgenic Lungs

    L. Burdorf, E. Rybak, T. Zhang, A. Riner, G. Braileanu, X. Cheng, C. Phelps, D. Ayares, A. Azimzadeh, R. Pierson III

    Surgery, University of Maryland, Baltimore, MD; Revivicor, Inc., Blacksburg, VA

    Purpose: As previously reported, the development of GalTKO pigs with additional expression of hCD46 has contributed to a significantly improved outcome of lungs in an…
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