2013 American Transplant Congress
Effect of Pre-Transplant Serum Sodium on Survival Benefit of Liver Transplantation
Background: Hyponatremia is associated with higher waitlist mortality among end stage liver disease candidates awaiting liver transplantation(LT). However, studies show that such candidates also have…2013 American Transplant Congress
IL37 Controls IL18 Induced Pro-Inflammatory Cytokine Expression by Tubular Cells and Attenuates Renal Ischemia-Reperfusion Injury
IL37 is a newly described member of the IL-1 family,which is anti-inflammatory by its inhibition of pro-inflammatory cytokine production. While human IL37 has no murine…2013 American Transplant Congress
Compartmentalization of Acute Versus Chronic Rejection in Cardiac Allografts
Immunology, Cleveland Clinic, Cleveland, OH
Acute rejection of cardiac allografts is characterized by interstitial infiltrates and diagnosed by endomyocardial biopsies. In contrast, chronic rejection is distinguished by vasculopathy in large…2013 American Transplant Congress
Rapamycin-Induced Augmentation of the CD8 T Cell Response to a Latent Viral Infection Is Inhibited by CTLA4-Ig
Latent viral infections are a major concern among immunosuppressed transplant patients. Treatment with belatacept, a CTLA4-Ig fusion protein, was shown to reduce toxicity in kidney…2013 American Transplant Congress
Impact of Cholecalciferol Repletion on Alloreactivity in Vitamin D-Deficient Hemodialysis Patients: A Randomized Controlled Trial
Dept of Medicine, Mount Sinai School of Medicine, NY, NY
Background: 25OH-Vit D deficiency is common in hemodialysis (HD) patients despite therapy with 1,25OH-Vit D, and is associated with increased T cell memory. The purpose…2013 American Transplant Congress
Epitope Matching Outperforms Traditional Antigen Matching as a Predictor of De Novo Donor Specific Antibody Development after Renal Transplantation
Hypothesis:An epitope based HLA matching approach will be predictive of de novo Donor Specific Antibody (dnDSA) development after renal transplantation.Methods:315 consecutive renal transplants were performed…2013 American Transplant Congress
Therapeutic Dosing of Mycophenolate Mofetil (MMF) in Renal Allograft Recipients Decreases with Increasing Age
PinnacleHealth, Harrisburg, PA
Background: Measurement of 2-hour Mycophenolic Acid Area-Under-Cure (MPA AUC) has been shown to allow accurate dosing of MMF for therapeutic efficacy. While inadequate MMF administration…2013 American Transplant Congress
Evolving Face of Liver Donors: Updating the Donor Risk Index, The
Background Derived from 1998-2002 liver transplant (LT) data, the DRI has served as a common language to analyze LT utilization practices and outcomes. We examined…2013 American Transplant Congress
Cell Necrosis and Immune Activation: Does Injury Alter Acquired Alloimmunity?
Emory Transplant Center, Atlanta, GA
Adaptive immune responses are directed by specific recognition of antigen but are also driven by general contextual signs of injury. Organ transplantation provides both of…2013 American Transplant Congress
UNOS Regional Risk Factors for Graft Failure in Kidney Transplantation
Aim: To identify UNOS regional variations in graft failure.Methods: UNOS database of 17,273 adult recipients transplanted from 06-30-2004 to 01-01-2007. Potential risk factors of interest…
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