2013 American Transplant Congress
Face Transplantation with Combined Hematopoietic Stem Cell Infusion and Vascularized Bone Marrow Transplantation Is Not Associated with Mixed Chimerism in Humans
In rat models of limb allograft transplantation, the combination of vascularized bone marrow transplantation (VBMT) with both Csa and anti-TCR mAb is associated with the…2013 American Transplant Congress
Anti-HLA Immunization Profile at the Time and after Renal Allograft Nephrectomy
IntroductionAllograft nephrectomy is a major risk factor for alloimmunization and can increase time on the waiting-list and acute antibody-mediated rejection. Anti-HLA immunization profile, DSA and…2013 American Transplant Congress
Candidate to Renal Transplant Evaluation: Difficulties in the Access to the Waiting List
Unidad de Trasplante Renal, CRAI SUR, HIGA San Martin, La Plata, Buenos Aires, Argentina
Background: The selection of candidates for kidney transplantation remains a challenge due to complex medical and social situations. There is a progressive increase in the…2013 American Transplant Congress
Subtle Deregulation of Circadian Rhythm in Mice with Partial A20 Knockdown Severely Impacts Lipid Metabolism Following Partial Hepatectomy Causing Defective Regeneration and Increased Lethality
Overexpression of A20 promotes liver regeneration (LR), but contribution of physiologic A20 to LR remains unclear. We performed 2/3 partial hepatectomy (PH) in A20 heterozygous…2013 American Transplant Congress
Alemtuzumab Mitigates the Risk of Early Rejection Associated with Delayed Graft Function in Deceased Donor Renal Transplantation
Imperial College Kidney and Transplant Centre, London, United Kingdom
Delayed graft function [DGF] is associated with rejection [AR] and allograft loss. It is postulated that ischaemic injury up regulates the expression of allograft MHC…2013 American Transplant Congress
Tolerance Induction Changes Lymph Node Structure and Function
Centre for Vascular and Inflammatory Diseases, University of Maryland, Baltimore, MD
BackgroundCostimulatory blockade plus donor-specific splenocyte transfusion (DST) induces long-term graft acceptance, however the mechanism by which this tolerance occurs remains incompletely defined. The lymph node…2013 American Transplant Congress
Chimerism and Tolerance without GVHD in Mismatched Recipients of Combined Hematopoietic Stem Cell/Kidney Transplants: Donor-Specific Hyporeactivity Is Not a Reliable Biomarker for Tolerance
We recently reported that low-intensity conditioning combined with facilitating cell (FC)-enriched hematopoietic stem cell transplantation (FCRx) can safely achieve high level, durable donor chimerism in…2013 American Transplant Congress
Ex Vivo Expanded Human Regulatory T Cells Are Potent Suppressors but May Be Short-Lived
Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA
Infusion of host derived ex vivo expanded regulatory T cells (eTregs) is an attractive therapeutic strategy for promotion of transplant tolerance. We report herein that…2013 American Transplant Congress
Evaluation of Non-Adherence in Patients Undergoing Dialysis, Pre- and Post-Kidney Transplantation: US Transplant Practice Patterns Survey
Introduction: We carried out a survey of US transplant centers to evaluate practice patterns in the assessment of non-adherence before and after kidney transplantation.Methods: An…2013 American Transplant Congress
Discrepancy between Biological Age and Calendar Age: A Large Histology Study in Implantation Biopsies, The
University Hospitals Leuven, Leuven, Belgium; Hasselt University, Hasselt, Belgium
BACKGROUNDThe histology and function of kidneys is thought to deteriorate with increasing age. Replicative senescence, associated with telomere shortening, plays an important role in this…
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