2013 American Transplant Congress
Role of the Alternative Pathway of Complement in Ischemia/Reperfusion and Chronic Graft Injury in a Mouse Model of Kidney Allograft
Transplant Research Center, Mario Negri Institute, Bergamo, Italy
Several studies suggested that activation of the alternative pathway (AP) of complement participates in kidney ischemia/reperfusion (I/R) injury. In mouse models of renal artery clamping,…2013 American Transplant Congress
Thymoglobulin Plus Basiliximab vs Basiliximab as Induction Therapy in Deceased Donor Kidney Transplant Recipients Treated with Tacrolimus and Mycophenolate Mofetil: 1-Year Results of a Prospective Clinical Trial
Surgery - Renal Transplantation, Catholic University, Rome, Italy
Purpose. The aim of this prospective, exploratory, single center study in kidney transplantation was to compare two immunosuppressive induction regimens: thymoglobulin plus basiliximab (THY) versus…2013 American Transplant Congress
Hypoxia Enhances Dendritic Cell Antigen Presentation through the Indirect Pathway
Transplant Research Center, Mario Negri Institute, Bergamo, Italy
Evidence is available that, in kidney transplantation, ischemic injury causes activation of intragraft dendritic cells (DCs), a key event for T cell alloactivation through the…2013 American Transplant Congress
Dynamics of Donor-Specific Antibodies in Kidney Transplantation: Pretransplant Anti-HLA Class I DSA Not Associated to Early Graft Loss Disappear after Transplantation under Conventional Immunosuppression
The impact of donor-specific antibodies(DSA) after kidney transplantation(KT) on graft survival is becoming clearer, but which DSA have the greater impact or how they behave…2013 American Transplant Congress
Donor-Specific HLA Antibodies in Crossmatch Negative Renal Transplant Patients Associates with Delayed Graft Function
In kidney transplantation delayed graft function (DGF) is a significant clinical problem affecting the kidney allograft during the whole clinical course. DGF also leads to…2013 American Transplant Congress
Primary Graft Dysfunction vs. Primary Graft Failure: Are All Graft Problems Created Equal?
Cardiac Surgery, Medical University of Vienna, Vienna, Austria
Background: Primary graft dysfunction (PGD) and failure (PGF) are severe complications after heart transplantation. Until now there are no common guidelines to differentiate between these…2013 American Transplant Congress
Dendritic Cells Phenotype Fitting under Hypoxia or LPS. ABC Transporters Far beyond an Efflux Pump
Nephrology Department, IDIBELL. Hospital Universitari Bellvitge, Barcelona, Spain
This study examines ABC-transporters as a potential therapeutic target in dendritic cell (DC) modulation under hypoxia and LPS. Functional capacity of DCs (mixed lymphocyte reaction,…2013 American Transplant Congress
Immune Regulation by Fibroblastic Reticular Cells in Tolerance Involves CD40-CD40L Costimulatory Interactions
University of Maryland, Baltimore
Background: Costimulatory blockade with anti-CD40L mAb plus donor specific splenocyte transfusion (DST) induces alloantigen specific tolerance. Previously we showed that stromal cell interactions with leukocytes,…2013 American Transplant Congress
AMPK Activator Promotes, but Complement and Thrombin Inhibit Anti-A/B Antibody-Induced Accommodation in Endothelial Cells
[Purpose] Several efforts have been made to define the mechanisms of accommodation termed as a condition without graft rejection even in the presence of anti-donor…2013 American Transplant Congress
Is There More Stress or Coercion To Donate in KPD Donors?
BACKGROUND:Kidney paired donation (KPD) is growing fast. The donors in KPD, or chain donors (Ch-D), have never before been studied from a psychosocial aspect or…
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