2013 American Transplant Congress
Impact of mTOR and Calcineurin Inhibition on Lipid and Glucose Metabolism – 24 Month Assessment in De Novo Liver Transplant Recipients Treated with Everolimus and Tacrolimus
For the H2304 Investigators, Hamburg, Germany; Novartis Pharma AG, Basel, Switzerland
Immunosuppressants, particularly corticosteroids (CS) and calcineurin inhibitors used after liver transplantation (LTx) can adversely affect lipid metabolism. mTOR inhibition blocks insulin-stimulated lipoprotein lipase and can…2013 American Transplant Congress
There Is No Difference in Patient Survival after Liver Transplantation between Induction with Rabbit ATG and Basiliximab in Recipients with HCV, However, There Appears To Be Less Severe Fibrosis with rATG
University of Washington, Seattle
rATG has gained acceptance for induction in liver transplantation. However, due to its strength as an immunosuppressive agent, there is concern that it may be…2013 American Transplant Congress
Soluble FGL2 Mediates Acute Rejection in Renal Allograft Recipients by Inducing Tubular Epithelial Cells Apoptosis
Background: Acute rejection (AR), initiated by infiltrating alloreactive T cells, hampers renal allograft survival. Tubular epithelial cells (TECs) are primary target in AR. TECs apoptosis…2013 American Transplant Congress
Effect of Nrf2-keap1 Pathway Activation on Human Pancreatic β Cells, The
Backgrounds: Islets are known to contain low level of antioxidants which renders them vulnerable to oxidative stress. It is also known that islets are exposed…2013 American Transplant Congress
Neutralization of Extracellular HMGB1 Suppresses Xeno-Immune Response and Delays Xenograft Rejection in a Rat-to Mouse Cardiac Xenotransplant Model
Background: Extracellular HMGB1 has been found to be a potent stimulator for adaptive immune responses. It has been reported that blockade of extracellular HMGB1 significantly…2013 American Transplant Congress
Does Extended Criteria Donor Kidney Biopsy Predict Five-Year Patient and Graft Survival?
UCLA David Geffen School of Medicine, Los Angeles, CA
Purpose: Donor biopsy is frequently used to assess extended criteria donor (ECD) organ quality, but the effect on patient survival and graft survival is less…2013 American Transplant Congress
Obesity Is a Major Barrier to Increasing Living Kidney Donation in the United States
Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA
Background: The number of living kidney donors has failed to increase in over a decade. There is limited data on the percentage of living kidney…2013 American Transplant Congress
Protective Effect of Carbon Monoxide-Releasing Molecules in Renal Ischemia-Reperfusion Injury Is Associated with Profound Inhibition of HMGB1 Cytoplasmic Translocation, The
Background: carbon monoxide-releasing molecules (CORMs) can significantly protect against renal ischemia-reperfusion injury (IRI), however, the mechanisms have not been fully elucidated. HMGB1 can be passively…2013 American Transplant Congress
Network Analysis Reveals Roles of Inflammation Factors in Different Phenotypes of Kidney Transplantation Patients
Zhongshan Hospital, Fudan University, Shanghai Key Lab of Organ Transplantation, Shanghai, China
BackgroundSystems-level characterization of inflammation in kidney transplantation remains incomplete. The present study aimed at identifying the inflammation proteins in phenotype transformation and assessing potential biomarkers…2013 American Transplant Congress
Outcomes on the Simultaneous Pancreas-Kidney (SPK) Transplant Waitlist: A Competing Risk Analysis of the UNOS Database
Kidney Transplant Research Center, UCLA David Geffen School of Medicine, Los Angeles, CA
Objective: To determine the risk of competing outcomes for patients on the waitlist for Simultaneous Pancreas-Kidney (SPK) transplantation.Design: We used the OPTN/UNOS database to examine…
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