2013 American Transplant Congress
Neutralization of Extracellular HMGB1 Suppresses Xeno-Immune Response and Delays Xenograft Rejection in a Rat-to Mouse Cardiac Xenotransplant Model
Background: Extracellular HMGB1 has been found to be a potent stimulator for adaptive immune responses. It has been reported that blockade of extracellular HMGB1 significantly…2013 American Transplant Congress
Does Extended Criteria Donor Kidney Biopsy Predict Five-Year Patient and Graft Survival?
UCLA David Geffen School of Medicine, Los Angeles, CA
Purpose: Donor biopsy is frequently used to assess extended criteria donor (ECD) organ quality, but the effect on patient survival and graft survival is less…2013 American Transplant Congress
Obesity Is a Major Barrier to Increasing Living Kidney Donation in the United States
Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA
Background: The number of living kidney donors has failed to increase in over a decade. There is limited data on the percentage of living kidney…2013 American Transplant Congress
Protective Effect of Carbon Monoxide-Releasing Molecules in Renal Ischemia-Reperfusion Injury Is Associated with Profound Inhibition of HMGB1 Cytoplasmic Translocation, The
Background: carbon monoxide-releasing molecules (CORMs) can significantly protect against renal ischemia-reperfusion injury (IRI), however, the mechanisms have not been fully elucidated. HMGB1 can be passively…2013 American Transplant Congress
Network Analysis Reveals Roles of Inflammation Factors in Different Phenotypes of Kidney Transplantation Patients
Zhongshan Hospital, Fudan University, Shanghai Key Lab of Organ Transplantation, Shanghai, China
BackgroundSystems-level characterization of inflammation in kidney transplantation remains incomplete. The present study aimed at identifying the inflammation proteins in phenotype transformation and assessing potential biomarkers…2013 American Transplant Congress
Outcomes on the Simultaneous Pancreas-Kidney (SPK) Transplant Waitlist: A Competing Risk Analysis of the UNOS Database
Kidney Transplant Research Center, UCLA David Geffen School of Medicine, Los Angeles, CA
Objective: To determine the risk of competing outcomes for patients on the waitlist for Simultaneous Pancreas-Kidney (SPK) transplantation.Design: We used the OPTN/UNOS database to examine…2013 American Transplant Congress
Donor CISH Polymorphism Is Associated with Allograft Outcomes in Kidney Transplantation
Background: Cytokine-inducible SH-2 containing protein (CISH) is a member of suppressor of cytokine signaling (SOCS) family and involved in the negative regulation of IL-2 mediated…2013 American Transplant Congress
Analysis of miRNAs in Peripheral Blood Mononuclear Cells: Potential Value of miR-182 as a Biomarker of Chronic Antibody Mediated Rejection
[Purpose] All donor specific antibodies (DSAs) cannot cause chronic antibody-mediated rejection (CAMR), as grafts of renal transplant recipients with DSAs have shown different outcomes. Although…2013 American Transplant Congress
Single Dose of Rituximab Results in a Long Lasting B-Cell Depletion in Peripheral Blood, without Affecting the Peripheral T-Cell Compartment, A
The B-cell depleting antibody rituximab is widely used for the treatment of B-cell malignancies and autoimmune disorders. In organ transplantation, it is especially applied to…2013 American Transplant Congress
PD-1 Analysis on CD28-CD27- CD4 T-Cells Allows Rapid Stimulation-Independent Assessment of CMV-Viremic Episodes in Transplant Recipients
We have previously shown that a high PD-1 expression on CMV-specific CD4 T-cells defines an anergic phenotype that is associated with CMV viremia in patients…
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